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Do I Need A Biopsy?


deena647

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deena647 Apprentice

Hello, I am so happy to have found this site. I was given a blood test after I went in for a yearly physical a few weeks ago and I told my DR. that I thought I had a wheat allergy. The blood test came back positive. I do have times when I feel great and other times I rack my brain trying to think of what I did wrong in my eating. My DR. has not said any more about further testing, do I need to get a biopsy or is the blood test good enough? I have so many questions and I am thankful to have found you all......Deena


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psawyer Proficient

Welcome, Deena,

I am certainly not an expert on the blood tests--there are several. I was diagnosed by a biopsy almost six years ago. In those years, the blood tests have improved and it is now possible to make a clinical diagnosis based upon the results from a combination of tests for antibodies. I don't know the specifics, but I'm sure someone on here will step forward with them. A positive biopsy for damage to the villi is conclusive, but may not be necessary.

Search this board for Iga and Igg tests and you may find the answer, assuming you know which tests were run and what the results were.

Whether it is a wheat allergy, or celiac, you will find lots of help on here about following a wheat- and gluten-free diet.

MySuicidalTurtle Enthusiast

I only had a blood test but my brother had both to become diagnosed Celiacs.

ravenwoodglass Mentor
Hello, I am so happy to have found this site. I was given a blood test after I went in for a yearly physical a few weeks ago and I told my DR. that I thought I had a wheat allergy. The blood test came back positive. I do have times when I feel great and other times I rack my brain trying to think of what I did wrong in my eating. My DR. has not said any more about further testing, do I need to get a biopsy or is the blood test good enough? I have so many questions and I am thankful to have found you all......Deena

If your doctor is satisfied with the diagnosis without putting you through the endo be thankful. Just make sure you avoid topical glutens as well as foods, check you toiletries, shampoos, lipsticks et al. The folks here are wonderfully helpful and welcome to the family.

fastcatkerry Newbie

How do they perform the biopsy for Celiac? My doctor has told me I have DH and now is talking about doing a biopsy to test further. Is it similar to a colonoskopy?

KaitiUSA Enthusiast

Biopsies can only rule celiac in but not out so if it comes back negative you may still have celiac.

There is a full celiac panel that should be run and it is very accurate:

EMA

IgG

IgA

tTG

Total Serum IgA

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      Welcome to the celiac.com communiuty, @Matthias! Yes, we have been aware that this can be an issue with mushrooms but as long as they are rinsed thoroughly it should not be a problem since the mushrooms don't actually incorporate the gluten into their cellular structure. For the same reason, one needs to be careful when buying aged cheeses and products containing yeast because of the fact that they are sometimes cultured on gluten-containing substrate.
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      The one kind of food I had been buying and eating without any worry for hidden gluten were unprocessed veggies. Well, yesterday I discovered yet another pitfall: cultivated mushrooms. I tried some new ones, Shimeji to be precise (used in many asian soup and rice dishes). Later, at home, I was taking a closer look at the product: the mushrooms were growing from a visible layer of shredded cereals that had not been removed. After a quick web research I learned that these mushrooms are commonly cultivated on a cereal-based medium like wheat bran. I hope that info his helpful to someone.
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      I might suggest you consider buckwheat groats. https://www.amazon.com/Anthonys-Organic-Hulled-Buckwheat-Groats/dp/B0D15QDVW7/ref=sr_1_4_pp?crid=GOFG11A8ZUMU&dib=eyJ2IjoiMSJ9.bk-hCrXgLpHqKS8QJnfKJLKbKzm2BS9tIFv3P9HjJ5swL1-02C3V819UZ845_kAwnxTUM8Qa69hKl0DfHAucO827k_rh7ZclIOPtAA9KjvEEYtaeUV06FJQyCoi5dwcfXRt8dx3cJ6ctEn2VIPaaFd0nOye2TkASgSRtdtKgvXEEXknFVYURBjXen1Nc7EtAlJyJbU8EhB89ElCGFPRavEQkTFHv9V2Zh1EMAPRno7UajBpLCQ-1JfC5jKUyzfgsf7jN5L6yfZSgjhnwEbg6KKwWrKeghga8W_CAhEEw9N0.eDBrhYWsjgEFud6ZE03iun0-AEaGfNS1q4ILLjZz7Fs&dib_tag=se&keywords=buckwheat%2Bgroats&qid=1769980587&s=grocery&sprefix=buchwheat%2Bgroats%2Cgrocery%2C249&sr=1-4&th=1 Takes about 10 minutes to cook. Incidentally, I don't like quinoa either. Reminds me and smells to me like wet grass seed. When its not washed before cooking it makes me ill because of saponins in the seed coat. Yes, it can be difficult to get much dietary calcium without dairy. But in many cases, it's not the amount of calcium in the diet that is the problem but the poor uptake of it. And too much calcium supplementation can interfere with the absorption of vitamins and minerals in general because it raises gut pH.
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      What you’re describing really does not read like typical IBS-D. The dramatic, rapid normalization of stool frequency and form after removing wheat, along with improved tolerance of legumes and plant foods, is a classic pattern seen in gluten-driven disease rather than functional IBS. IBS usually worsens with fiber and beans, not improves. The fact that you carry HLA-DQ2.2 means celiac disease is absolutely possible, even if it’s less common than DQ2.5, and many people with DQ2.2 present later and are under-diagnosed. Your hesitation to reintroduce gluten is completely understandable — quality of life matters — and many people in your position choose to remain strictly gluten-free and treat it as medically necessary even without formal biopsy confirmation. If and when you’re ready, a physician can help you weigh options like limited gluten challenge, serology history, or documentation as “probable celiac.” What’s clear is that this wasn’t just random IBS — you identified the trigger, and your body has been very consistent in its response.
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