Does Type/amount Of Genes Make A Difference?

[Peta]

I have been trying to look up a question on the internet but cannot get an answer.

The people on this site seem to have more knowledge of celiac than anywhere else you hopefully you can help.

Does it make a difference to the likelihood of having celiac if you have certain combinations of the DQ2 and DQ8 genes?

If my son has both DQ8 genes and both DQ2 genes does that make him any more likely to have celiac than say someone with only one, or a combination of 2 genes??

Just curious.

Thanks,

Peta

[tarnalberry]

Read this. You'll probably find it elucidating.

The HLA-DQ2 Gene Dose Effect in Celiac Disease is Directly Related to the Magnitude and Breadth of Gluten-Specific T-Cell Reponses

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In-depth discussion on difference between DQ2.5 and DQ2.2 homo- and heterozygous individuals and binding affinity to various gliandin peptides. Implications include the method of presentation of gluten to susceptible individuals.

[GlutenWrangler]

Combinations of DQ2 and DQ8, or DQ2 and DQ2, or DQ8 and DQ8, are all high susceptibility factors for celiac disease. Your son would have a higher chance of getting celiac disease, and the potential for a more severe dietary reaction to gluten. I'm not sure if this answers your question, but I hope it helps.

-Brian

[Peta]

Thankyou for your responses.

I have SOOOO many questions that I wish I could connect my computer directly into your brains and extract all that wonderful information....as I'm hesitant to drive you all mad on this site by asking my hundreds of mindless questions!

Peta

[mommida]

Ask all the questions you want.

When a question gets asked someone pulls up another article I haven't read yet. So you help so many people in the long run.

L.