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Celiac Cure.... A Possible Pill To Cure Celiac

PizzaGuy

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new to LI Newbie
new to LI
Posted

just GI symptoms, and i have never tried after glutened. i always take before eating out. i get very minor queasiness and i know of CC and feel thankful for the pill.

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Nantzie Collaborator
Nantzie
Posted

I might have to give it a shot the next time we go to on one of those trips. What name do your's go by. I've heard of Glutenease and Glutenzyme.

Nancy

new to LI Newbie
new to LI
Posted

hi nancy

i use kirkman labs DPP-IV Forte. it says the activity is 60,000 HUT.

i saw glutenease at the store the other day, when i run out of what i have i was going to try it.

gfp Enthusiast
gfp
Posted
Then there's also the case of the British drug company who did phase 1 trials of a drug designed to block the immune system (to help deal with autoimmune diseases and cancers) which showed no negative side-effects in apes, but nearly killed six of the seven healthy volunteers (elephantosis, kidney, liver, heart, lung and pancreatic damage, and ended up in comas!!) - three of whom now (six months later) have late-stage cancer as a direct side-effect of the trial. We know much less about the human body, immune system and genetic code than we like to think we do.

Yes, I posted this a long time ago...

2kids4me Contributor
2kids4me
Posted

I guess I don't get real excited when a "cure" or pill is in the near future... I was diagnosed with Type 1 diabetes in 1986 and at that time they figured a"cure" was imminent...well here we are 21 years later.......the only cure involves islet cell transplants and you need immune suppressents for that "cure". Diabetes has been researched for years and they still dont know how to stop the immune process from destroying islet cells.

I agree with posters being concerned about side effects from pills...the body is an fine tuned machine. We all know that a food intolerance can wreak havoc ...more so celiac where the immune system goes into high gear against it's host. What will this pill do?

So they found Zonulin affects the intestinal barrier - do they know what else it does?

Autoimmune diseases are tricky bunch - it involves T cells, thymus glands, genetic markers, and the elusive trigger to get it all going.

The proven treatment is to avoid gluten - yes it's a pain and it can be expensive.

The proven treatment for diabetes is insulin (Type 1) ...a bigger pain and expensive.

Systemic Lupus - treat symtoms - no pill or diet can treat it completely because it affects so many organs (including the skin)

MS - ongoing mystery - affects some more than others progresses rapidly or slowly..

Autoimmune hepatitis - treatment is steroids/immune suppressents... whack of side effects there.

and on and on for the long list of autoimmune disorders...

Maybe I am "defeatest"..oh well... I am not going to get all excited about some miracle cure. I will keep truckin along with what I've got and be glad for the good days and hope one day they figure out how to stop the immune system from "attacking self".

Maybe I think differently because I am not going to get my kids all wound up - "they may have a pill soon!" Only to end up 21 years later taking the same "treatment"..... perhaps I do resent being given false hope years ago and then when my son was diagnosed -we were told (again)...a cure is around the corner...so my son comes home thinking by the time he's 16, he wont need insulin. Um, dont think so.........

Sandy

Cam's Mom Contributor
Cam's Mom
Posted

Hi!

Sorry this is kind of a long post but I am includng information sent to me by my brother who is a Pharmacologist, Ph.D. who owns a consulting company in the NY area that helps pharmaceutical companies bring new products to market (amongst other things). He looked into the issue of celiac and diabetes since my daughter (his neice) was recently diagnosed and he is a totally stand up guy. He has mentioned to me that the drugs being developed by Alba are in phase 2 clinical trials. The information put together by his employees includes the following:

"...The rationale is that ingesting an enzyme oral therapy before consuming gluten would break up the gluten into non-toxic food to prevent the triggered immune response and the resulting inflammatory damage.

Although there are no products currently on the market, there are a few that remain in developmental stages. Alvine Pharmaceuticals is researching ALV001 and ALV002 which are oral therapies comprised of enzymes. ALV002 contains both a recombinant cysteine endoprotease found in barley seeds, EP-B2 (breaks down gluten proteins), and prolyl endoprotease, PEP (detoxifies gluten). ALV001 only includes EP-B2, whereas ALV002 contains both enzymes for greater tolerance of gluten in one

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    • knitty kitty
      Desperately need a vitamin D supplement. I've reacted to most brands I've tried.

      By knitty kitty · Posted

      @Jane02, I hear you about the kale and collard greens.  I don't do dairy and must eat green leafies, too, to get sufficient calcium.  I must be very careful because some calcium supplements are made from ground up crustacean shells.  When I was deficient in Vitamin D, I took high doses of Vitamin D to correct the deficiency quickly.  This is safe and nontoxic.  Vitamin D level should be above 70 nmol/L.  Lifeguards and indigenous Pacific Islanders typically have levels between 80-100 nmol/L.   Levels lower than this are based on amount needed to prevent disease like rickets and osteomalacia. We need more thiamine when we're physically ill, emotionally and mentally stressed, and if we exercise like an athlete or laborer.  We need more thiamine if we eat a diet high in simple carbohydrates.  For every 500 kcal of carbohydrates, we need 500-1000 mg more of thiamine to process the carbs into energy.  If there's insufficient thiamine the carbs get stored as fat.  Again, recommended levels set for thiamine are based on minimum amounts needed to prevent disease.  This is often not adequate for optimum health, nor sufficient for people with absorption problems such as Celiac disease.  Gluten free processed foods are not enriched with vitamins like their gluten containing counterparts.  Adding a B Complex and additional thiamine improves health for Celiacs.  Thiamine is safe and nontoxic even in high doses.  Thiamine helps the mitochondria in cells to function.  Thiamine interacts with each of the other B vitamins.  They are all water soluble and easily excreted if not needed. Interesting Reading: Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet https://pubmed.ncbi.nlm.nih.gov/19154566/ Safety and effectiveness of vitamin D mega-dose: A systematic review https://pubmed.ncbi.nlm.nih.gov/34857184/ High dose dietary vitamin D allocates surplus calories to muscle and growth instead of fat via modulation of myostatin and leptin signaling https://pubmed.ncbi.nlm.nih.gov/38766160/ Safety of High-Dose Vitamin D Supplementation: Secondary Analysis of a Randomized Controlled Trial https://pubmed.ncbi.nlm.nih.gov/31746327/ Vitamins and Celiac Disease: Beyond Vitamin D https://pmc.ncbi.nlm.nih.gov/articles/PMC11857425/ Investigating the therapeutic potential of tryptophan and vitamin A in modulating immune responses in celiac disease: an experimental study https://pubmed.ncbi.nlm.nih.gov/40178602/ Investigating the Impact of Vitamin A and Amino Acids on Immune Responses in Celiac Disease Patients https://pmc.ncbi.nlm.nih.gov/articles/PMC10814138/
    • Jane02
      Desperately need a vitamin D supplement. I've reacted to most brands I've tried.

      By Jane02 · Posted

      Thank you so much @knitty kitty for this insightful information! I would have never considered fractionated coconut oil to be a potential source of GI upset. I will consider all the info you shared. Very interesting about the Thiamine deficiency.  I've tracked daily averages of my intake in a nutrition software. The only nutrient I can't consistently meet from my diet is vitamin D. Calcium is a hit and miss as I rely on vegetables, dark leafy greens as a major source, for my calcium intake. I'm able to meet it when I either eat or juice a bundle of kale or collard greens daily haha. My thiamine intake is roughly 120% of my needs, although I do recognize that I may not be absorbing all of these nutrients consistently with intermittent unintentional exposures to gluten.  My vitamin A intake is roughly 900% (~6400 mcg/d) of my needs as I eat a lot of sweet potato, although since it's plant-derived vitamin A (beta-carotene) apparently it's not likely to cause toxicity.  Thanks again! 
    • knitty kitty
      Desperately need a vitamin D supplement. I've reacted to most brands I've tried.

      By knitty kitty · Posted

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    • Scott Adams
      Desperately need a vitamin D supplement. I've reacted to most brands I've tried.

      By Scott Adams · Posted

      I do not know this, but since they are labelled gluten-free, and are not really a product that could easily be contaminated when making them (there would be not flour in the air of such a facility, for example), I don't really see contamination as something to be concerned about for this type of product. 
    • trents
      Desperately need a vitamin D supplement. I've reacted to most brands I've tried.

      By trents · Posted

      Contact them.
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