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Elevated Igg


mom22kids

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mom22kids Rookie

Just wondering what exactly this means. We had the formal results of the test today. The doctor said the IgG was elevated but the IgA and tTg were normal. The blood work also indicated an inflammation in the bowels. He is not ruling out Celiac and said that is still very possible as well as Crohn's.

What exactly does an elevated IgG mean when the others are normal?


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Jestgar Rising Star

You sorta need to know which IgG, but I'm assuming gliadin.

The anti-gliadin IgG can go up with other intestinal malabsorption type things, not just Celiac.

Also, did they do tTg IgG and IgA? and total IgA?

If they only did IgA antibodies, and not total IgA, it could be an IgA deficiency.

Maybe you could get them to send you a copy of the lab results.

mom22kids Rookie

They did the Celiac panel. The others in the test were normal.

confused Community Regular
They did the Celiac panel. The others in the test were normal.

The same thing happened with my sons results, we are still trying to figure out what is going on with him. We see the specialist on the 11 of april.

What made your dr say he is not going to rule out crohns of celiac.

paula

mom22kids Rookie

There's been almost no weight gain in the last 10 months. They did find an inflammation in the bowels with the blood work, which makes him suspect Crohns. She has the typical rash that Celiac patients get and sores in the mouth - but no other symptoms. She has an almost constant need to eat every hour to hour and half or look out it is meltdown time. They did do a hypoglycemic test and because she had eaten right before the test and it showed she was on the very low side or normal so they will retest that at the time of the endoscopy, which is scheduled in 2 weeks.

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      thank you RMJ! That is very helpful advice. Good to know we aren’t crazy if we don’t do the endoscopy. We are going to try the gluten free and see how symptoms and levels improve.    thank you Wheatwacked (love the username lol) that is also reassuring. Thankfully she has an amazing and experienced pediatrician. And yesss I forgot to mention the poop! She has the weirdest poop issues.    How long did it take y'all to start seeing improvement in symptoms? 
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      So her tissue transglutaminase antibody is almost 4x the upper end of the normal range - likely a real result. The other things you can do besides an endoscopy would be: 1.  Genetic testing.  Unfortunately a large proportion of the population has genes permissive for celiac disease, but only a small proportion of those with the genes have it. With family history it is likely she has the genes. 2.  Try a gluten free diet and see if the symptoms go away AND the antibody levels return to normal. (This is what I would do). Endoscopies aren’t always accurate in patients as young as your daughter. Unfortunately, without an endoscopy, some doctor later in her life may question whether she really has celiac disease or not, and you’ll need to be a fierce mama bear to defend the diagnosis! Be sure you have a good written record of her current pediatrician’s diagnosis. Doing a gluten challenge for an endoscopy later in life could cause a very uncomfortable level of symptoms.   Having yourself, your husband and your son tested would be a great idea.  
    • Samanthaeileen1
      here are the lab ranges.  Normal ranges for tissue transglutaminase are: <15.0 Antibody not detected > or = 15.0 Antibody detected normal for endomysial antibody is < 1.5. So she is barely positive but still positive. 
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