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L-glutamine For Leaky Gut

eLaurie

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eLaurie Rookie
eLaurie
Posted

I've been reading about l-glutamine's benefits for decreasing gut permeability. I've been gluten free for almost a year, casein free for 6 months and still don't have complete resolution of symptoms.

While I realize healing can take 2+ years, I'm ready now to start supplements and herbs (primarly ginger) to hopefully speed healing. I read about l-glutamine on another web site, then read some PubMed abstracts about its role in gut integrity, so am ready to give it a go.

I always like to hear success stories from people who've been doing things a while, so if you've been regularly taking l-glutamine for 3 - 6 months or longer, I'd love to hear your story.

And I don't mind negatives or no response stories if you've tried it for 3 -6 months.

A good link from this board about l-glutamine:

Open Original Shared Link

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lorka150 Collaborator
lorka150
Posted

I would not take ANYTHING without talking with your doctor. Some people have positive experiences, but that isn't the same for others.

I took L-Glutamine and ended up in the hospital, after reading all of the positive things. For me, it was completely negative, and dangerous.

eLaurie Rookie
eLaurie
Posted
  • Author

I'm not as worried about the adverse effects of l-glutamine as I am the consequences of gut permeability. I have a master's degree in nutrition, have read up on the pharmacology, and am titrating dosage slowly.

Thanks for your concern; I'm sorry you had a bad experience, but am trusting the professional literature that shows such occurances are rare.

The Lovebug Rookie
The Lovebug
Posted
I'm not as worried about the adverse effects of l-glutamine as I am the consequences of gut permeability.

What ARE the consequences of gut permeability?

lorka150 Collaborator
lorka150
Posted
I'm not as worried about the adverse effects of l-glutamine as I am the consequences of gut permeability. I have a master's degree in nutrition, have read up on the pharmacology, and am titrating dosage slowly.

Thanks for your concern; I'm sorry you had a bad experience, but am trusting the professional literature that shows such occurances are rare.

I literally did almost die - so I was quite worried. But, again, it was just my experience.

  • 2 weeks later...
goodlife Newbie
goodlife
Posted

eLaurie, I took L-glutamine for about 2 months only, as recommended from my Integrative Medicine doctor for leaky gut symptoms. Unfortunately, I did not see any results in my digestion. (I was taking a variety of other supplements, too.)

Since that time, however, I have cut down on my dairy and in the last 5 weeks, cut way down on my sugar (but not my carbs). I have been taking it again for a month or so.

I have improved since being off sugar, but it's so hard to attribute to one thing. L-glut certainly did not hurt me and may be helping. Who knows. I am taking 5-10 grams a day, which is a big-honkin' spoonful. It tastes weird unless it's in juice. You probably already know this. So while I am not really answering your question, know that there's someone out there that's taking it without knowing whether the results she's seeing are due to l-glut or not. I figure that all the herbs, vitamins, and supplements work synergistically and the proof will be how you feel in a month or two after being on the stuff regularly and as a package deal.

Good luck.

  • 2 years later...
BonnieM Newbie
BonnieM
Posted

I would not take ANYTHING without talking with your doctor. Some people have positive experiences, but that isn't the same for others.

I took L-Glutamine and ended up in the hospital, after reading all of the positive things. For me, it was completely negative, and dangerous.

What else were you taking along with the L-Glutamine? How much were you taking?

I've had celiac disease for two years and am having a hard time losing weight. I was told L-Glutamine would help cravings.

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    • knitty kitty
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      By knitty kitty · Posted

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    • captaincrab55
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    • rei.b
      High DGP-A with normal IGA

      By rei.b · Posted

      Okay well the info about TTG-A actually makes a lot of sense and I wish the PA had explained that to me. But yes, I would assume I would have intestinal damage from eating a lot of gluten for 32 years while having all these symptoms. As far as avoiding gluten foods - I was definitely not doing that. Bread, pasta, quesadillas (with flour tortillas) and crackers are my 4 favorite foods and I ate at least one of those things multiple times a day e.g. breakfast with eggs and toast, a cheese quesadilla for lunch, and pasta for dinner, and crackers and cheese as a before bed snack. I'm not even kidding.  I'm not really big on sugar, so I don't really do sweets. I don't have any of those conditions.  I am not sure if I have the genes or not. When the geneticist did my genetic testing for EDS this year, I didn't think to ask for him to request the celiac genes so they didn't test for them, unfortunately.  I guess another expectation I had is  that if gluten was the issue, the gluten-free diet would make me feel better, and I'm 3 months in and that hasn't been the case. I am being very careful and reading every label because I didn't want to screw this up and have to do gluten-free for longer than necessary if I end up not having celiac. I'm literally checking everything, even tea and anything else prepacked like caramel dip. Honestly its making me anxious 😅
    • knitty kitty
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      By knitty kitty · Posted

      So you're saying that you think you should have severe intestinal damage since you've had the symptoms so long?   DGP IgG antibodies are produced in response to a partial gluten molecule.  This is different than what tissue transglutaminase antibodies are  produced in response to.   TTg IgA antibodies are produced in the intestines in response to gluten.  The tTg IgA antibodies attack our own cells because a structural component in our cell membranes resembles a part of gluten.  There's a correlation between the level of intestinal damage with the level of tTg antibodies produced.  You are not producing a high number of tTg IgA antibodies, so your level of tissue damage in your intestines is not very bad.  Be thankful.   There may be reasons why you are not producing a high quantity of tTg IgA antibodies.  Consuming ten grams or more of gluten a day for two weeks to two months before blood tests are done is required to get sufficient antibody production and damage to the intestines.  Some undiagnosed people tend to subconsciously avoid lots of gluten.  Cookies and cakes do not contain as much gluten as artisan breads and thick chewy pizza crust.  Anemia, diabetes and thiamine deficiency can affect IgA antibody production as well.   Do you carry genes for Celiac?  They frequently go along with EDS.
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      I was tested for celiac at the same time, so I wasn't taking naltrexone yet. I say that, because I don't. The endoscopy showed some mild inflammation but was inconclusive as to celiac disease. They took several biopsies and that's all that was shown. I was not given a Marsh score.
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