Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

The Dq1 Gene

confused

Recommended Posts

confused Community Regular
confused
Posted

I have been reading and thinking about everyone and their enterolab test. I seem to find that most of us that have a dq1 gene have malabsorption when we get tested threw enterolab. Has anyone else noticed this.

So if you have the dq1, what was your malabsorption score.

paula

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


hathor Contributor
hathor
Posted

See below.

zarfkitty Explorer
zarfkitty
Posted

(edit)

My daughter had malabsorption somewhere in the low 300's range. She's double dq1.

confused Community Regular
confused
Posted
  • Author

I only carry one and had i think 374 i would have to look it up, but my stepson had no malabsorption but the celiac gene wiht dq1, i just find it odd that dq1 seem to have an high malabsorption compared to others.

what do others think about this.

paula

k-amy32 Rookie
k-amy32
Posted

Hi! I am a double DQ1 and my score was 1480!

bugstabber Rookie
bugstabber
Posted

I have double DQ1, malabsorbtion is 487.

stephanie19 Newbie
stephanie19
Posted

I don't mean to hijack this thread, but since it's about double DQ1, which I am as well, I hope you don't mind. I had a mildly elevated malabsorption score (346), but in addition to this question of malabsorption, I'm wondering if any of you know of any further characteristics associated with double DQ1. I've heard it's associated with neurological symptoms, but I don't really know what that means. Anyone know anything further about this or any other problems related to these genes? I'm trying to learn as much as I can about the genetics of this, so any input would be helpful.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


zarfkitty Explorer
zarfkitty
Posted
I don't mean to hijack this thread, but since it's about double DQ1, which I am as well, I hope you don't mind. I had a mildly elevated malabsorption score (346), but in addition to this question of malabsorption, I'm wondering if any of you know of any further characteristics associated with double DQ1. I've heard it's associated with neurological symptoms, but I don't really know what that means. Anyone know anything further about this or any other problems related to these genes? I'm trying to learn as much as I can about the genetics of this, so any input would be helpful.

I can't answer this question with any level of authority. But, my daughter is a very cranky, uncooperative, DRAMATIC little girl on gluten. I mean hysterics of gargantuan proportions, completely inappropriate for her age. When we started the diet, her true personality came back.

hathor Contributor
hathor
Posted
I don't mean to hijack this thread, but since it's about double DQ1, which I am as well, I hope you don't mind. I had a mildly elevated malabsorption score (346), but in addition to this question of malabsorption, I'm wondering if any of you know of any further characteristics associated with double DQ1. I've heard it's associated with neurological symptoms, but I don't really know what that means. Anyone know anything further about this or any other problems related to these genes? I'm trying to learn as much as I can about the genetics of this, so any input would be helpful.

Here are a couple abstracts. I don't know if the disorders mentioned exhaust the possibilities of neurological reactions to gluten. Probably not. I recall seeing one article, I think it was by the doctor here with the long name that mentioned the prevalence of DQ1 in the population he was examining, not just the typical "celiac genes." I don't recall him mentioning double DQ1, though. I wish I could figure out how I got access to that article for free one time! I should have printed it or bookmarked it.

Open Original Shared Link

Open Original Shared Link

BensMom Rookie
BensMom
Posted

My son is a double DQ1, and he was in the low 300 range. He has been dairy and wheat free for over a year and now we are pulling out gluten.

confused Community Regular
confused
Posted
  • Author

It is interesting to read how many dq1 people have malabsorption scores that are high or above the 300 mark. It just makes me wonder if maybe we have some sort of diease that is not proven yet but correlates with celiac. I am having a hard time putting what im thinking into words here. Im still ercovering from being glutened this week. When i can think more clearly i will type it all out. But do oyu all think, or am i just pulling at straws trying to figure this out.

paula

Rachel--24 Collaborator
Rachel--24
Posted

Single DQ1 gene.....malabsorption score = 912.

Even though Enterolab tests were positive (IgA and tTG) the cause of malabsorption was/is unrelated to gluten. Not to say that gluten didnt contribute...but there were other issues causing the malabsorption in my case.

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. Wheatwacked
      - Wheatwacked replied to MauraBue's topic in Gluten-Free Foods, Products, Shopping & Medications
      2

      Have Tru Joy Sweets Choco Chews been discontinued??

      M&M Peanuts. About the same calories and sugar while M&M Peanuts have fiber, potassium, iron and protein that Tootsie Rolls ("We are currently producing more than 50 million Tootsie Rolls each day.") don't. Click the links to compare nutritional values. Both are made with sugar, not high fructose corn syrup. I use them as a gluten free substitute...
    2. Theresa2407
      - Theresa2407 replied to chrish42's topic in Doctors
      6

      Doctors and Celiac.com

      I see it everyday on my feeds. They go out and buy gluten-free processed products and wonder why they can't heal their guts. I don't think they take it as a serious immune disease. They pick up things off the internet which is so far out in left field. Some days I would just like to scream. So much better when we had support groups and being able to teach...
    3. Scott Adams
      - Scott Adams replied to MauraBue's topic in Gluten-Free Foods, Products, Shopping & Medications
      2

      Have Tru Joy Sweets Choco Chews been discontinued??

      Some of the Cocomels are gluten and dairy-free: https://cocomels.com/collections/shop-page
    4. Scott Adams
      - Scott Adams replied to chrish42's topic in Doctors
      6

      Doctors and Celiac.com

      Thank you for the kind words! I keep thinking that things in the medical community are improving, but a shocking number of people still post here who have already discovered gluten is their issue, and their doctors ordered a blood test and/or endoscopy for celiac disease, yet never mentioned that the protocol for such screening requires them to be eating...
    5. trents
      - trents replied to catnapt's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      5

      how much gluten do I need to eat before blood tests?

      The rate of damage to the villous lining of the SB and the corresponding loss of nutrient absorbing efficiency varies tremendously from celiac to celiac. Yes, probably is dose dependent if, by dose dependent you mean the amount of exposure to gluten. But damage rates and level of sensitivity also seem to depend on the genetic profile. Those with both genes...
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      133,261
    • Most Online (within 30 mins)
      7,748
    Joanne Ham
    Newest Member
    Joanne Ham
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.6k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • Wheatwacked
      Have Tru Joy Sweets Choco Chews been discontinued??

      By Wheatwacked · Posted

      M&M Peanuts. About the same calories and sugar while M&M Peanuts have fiber, potassium, iron and protein that Tootsie Rolls ("We are currently producing more than 50 million Tootsie Rolls each day.") don't. Click the links to compare nutritional values.  Both are made with sugar, not high fructose corn syrup.  I use them as a gluten free substitute for a peanut butter sandwich.  Try her on grass fed, pasture fed milk. While I get heartburn at night from commercial dairy milk, I do not from 'grassmilk'.     
    • Theresa2407
      Doctors and Celiac.com

      By Theresa2407 · Posted

      I see it everyday on my feeds.  They go out and buy gluten-free processed products and wonder why they can't heal their guts.  I don't think they take it as a serious immune disease. They pick up things off the internet which is so far out in left field.  Some days I would just like to scream.  So much better when we had support groups and being able to teach them properly. I just had an EMA blood test because I haven't had one since my Doctor moved away.  Got test results today, doctor ordered a D3 vitamin test.  Now you know what  type of doctors we have.  Now I will have to pay for this test because she just tested my D3 end of December, and still have no idea about my EMA.    
    • Scott Adams
      Have Tru Joy Sweets Choco Chews been discontinued??

      By Scott Adams · Posted

      Some of the Cocomels are gluten and dairy-free: https://cocomels.com/collections/shop-page
    • Scott Adams
      Doctors and Celiac.com

      By Scott Adams · Posted

      Thank you for the kind words! I keep thinking that things in the medical community are improving, but a shocking number of people still post here who have already discovered gluten is their issue, and their doctors ordered a blood test and/or endoscopy for celiac disease, yet never mentioned that the protocol for such screening requires them to be eating gluten daily for weeks beforehand. Many have already gone gluten-free during their pre-screening period, thus their test results end up false negative, leaving them confused and sometimes untreated. It is sad that so few doctors attended your workshops, but it doesn't surprise me. It seems like the protocols for any type of screening should just pop up on their computer screens whenever any type of medical test is ordered, not just for celiac disease--such basic technological solutions could actually educate those in the medical community over time.
    • trents
      how much gluten do I need to eat before blood tests?

      By trents · Posted

      The rate of damage to the villous lining of the SB and the corresponding loss of nutrient absorbing efficiency varies tremendously from celiac to celiac. Yes, probably is dose dependent if, by dose dependent you mean the amount of exposure to gluten. But damage rates and level of sensitivity also seem to depend on the genetic profile. Those with both genes HLA-DQ2 and HLA-DQ8 seem to be more sensitive to minor amounts of gluten exposure than those with just one of those genes and those with only DQ2 seem to be more sensitive than those with only DQ8. But there are probably many factors that influence the damage rate to the villi as well as intensity of reaction to exposure. There is still a lot we don't know. One of the gray areas is in regard to those who are "silent" celiacs, i.e. those who seem to be asymptomatic or whose symptoms are so minor that they don't garner attention. When they get a small exposure (such as happens in cross contamination) and have no symptoms does that equate to no inflammation? We don't necessarily know. The "sensitive" celiac knows without a doubt, however, when they get exposure from cross contamination and the helps them know better what food products to avoid.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.