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Confused About Something


jasonD2

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jasonD2 Experienced

Ok so i understand antibodies to gluten can damage the intestines, well, what about other foods? if you're sensitive to casein or soy or corn could antibodies to these also destroy the villi? based on what i've read it seems that only gluten does tha,t but it doesnt make sense to me. so you can eliminate gluten from your diet but something else you're sensitive to can be causing problems?

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Guest j_mommy

From what I understand, yes if you are intolerant to other things they can cause damage as well!!!! At teh very least...slow the healing process after a person goes gluten-free!

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happygirl Collaborator

Technically yes they can, but it is very, very rare.

Other foods can certainly cause symptoms, but very very few, and in very few individuals, do the foods actually cause villi blunting.

From a leading Celiac expert at Columbia University

Causes of villous atrophy apart from celiac disease

In children less than two years old, there are several causes that include cows milk allergy, soy allergy, eosinophillic gastroenteritis, and viral gastroenteritis. In adults, HIV enteropathy and tropical sprue are the most common causes of villous atrophy apart from celiac disease. Radiation may cause a similar picture as well as autoimmune enteropathy. Other food intolerances have been reported though are exceptionally rare; they include a single case report of fish and chicken intolerance.

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nmw Newbie

I've been fanatically gluten-free for 17 months, developed issues with dairy, corn and soy this summer, had an EGD 3 weeks ago that showed villious blunting. I haven't had my follow-up yet, but will interrogate the dr. about this when I do. It's a good question and makes me wonder what they would have found had I requested the EGD when I went gluten-free.

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JennyC Enthusiast

The antibodies do not blunt the villi, the T-cells do when they release cytokines when exposed to gluten. This is an autoimmune reaction. Food allergies and intolerances are different, but they do cause symptoms.

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    • trents
      Keep in mind, Hannah, that of you are on a gluten free diet and want to get tested for celiac disease, any testing would be invalid until you were back on generous amounts of gluten for weeks/months.
    • Hannah2907
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    • Scott Adams
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    • trents
      Welcome to the forum community, @Hannah2907! I know this is going to be all very confusing, Hannah, but the first thing to realize is that celiac disease is not an allergy and it cannot be diagnosed by allergy testing. It is an autoimmune disorder characterized by an inflammatory reaction to the ingestion of the protein "gluten" which is found in wheat, barley and rye.  Autoimmune disorders speak to diseases where the body's immunes system attacks the body's own cells. In the case of celiac disease, when food containing gluten is ingested, it triggers an attack in the villous lining of the small bowel. This causes inflammation in the villous lining and produces characteristic antibodies that can be detected in the blood through certain lab tests. This inflammation often (but not always) causes discomfort and other GI distress and always wears down the villous lining. This "wearing down" of the villous lining over time causes increasing inefficiency of nutrient absorption and can cause serious vitamin and mineral deficiency related medical problems. The villous lining of the small bowel is essentially where all the nutrition in our food is absorbed. The damage done to the villous lining can also be detected through an upper GI scoping ("endoscopy") with a biopsy. The endoscopy/biopsy is typically used as confirmation when the antibody blood testing is positive for celiac disease. Celiac disease may also be referred to as "gluten intolerance".  There is another gluten-related disorder known as NCGS (Non Celiac Gluten Sensitivity). NCGS is also known simply as "gluten sensitivity" but, unfortunately, many people use the terms "gluten intolerance" "gluten sensitivity" interchangeably. NCGS is 10x more common than celiac disease and shares many of the same symptoms with celiac disease. The main difference is that celiac disease damages the villous lining of the small bowel whereas NCGS does not. There is no test for NCGS. Celiac disease must first be ruled out. Both require complete abstinence from gluten. Some experts believe that NCGS can be a precursor to celiac disease. The immune system pathway of NCGS is not well understood though, like celiac disease, it is not an allergy. My point in all of this is to help you understand that the testing you have undergone for allergies is not effective for diagnosing gluten disorders. You need to get blood antibody testing done that is specifically designed to detect celiac disease. Many people with gluten disorders also must avoid dairy and sometimes oats, even gluten-free oats. 
    • Scott Adams
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