Dq1,1 Subtype Associated With Gluten Intolerance?

[bendano]

My DD (now 2) has had chronic diarrhea and failure to thrive for one year. She has had many tests for celiac and other GI disorders. Her blood test was neg and her biopsy was inconclusive. She had slight villous blunting and many lymphoid cells but not intraepithelial lymphocytes. We had her tested through Enterolab and she had an elevated fecal antigladin IgA of 63 and fecal transglutaminase IgA of 58. SHe has the HLA-DQB1 Allele 1 0501 and HLA-DQB1 Allele 2 06xx. She seems to be doing better on the gluten free diet now that we have also removed soy and she had been dairy free due to a milk allergy. Two pedi-GI's have recommended a gluten-free diet for her. We are searching for information about gluten intolerance without DQ 2 or DQ 8 subtypes and are finding little to no proof that such condition has been defined in medical literature. Any information would be greatly appreciated.

[Ursa Major]

Those genes have not been officially recognized as causing gluten intolerance by the medical community at large. But many here have them, and have terrible reactions to gluten, my own youngest daughter included (and since she is my kid, I probably have those same genes, or at least one of them, as well).

Those 'official' celiac disease genes are NOT the only genes causing celiac disease. In other countries they have recognized other genes for causing celiac disease, and they are still finding more.

If your daughter at her young age had some blunting of the villi already, they likely would have been flat in a couple of years. I am glad she has sensible GIs who want her on a gluten-free diet. There are too many ignorant doctors out there who would just tell you that there is no way she has celiac disease, and to keep her eating gluten.

[nora-n]

I collected some non-DQ2 or 8 links here on this slow-moving forum:

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Note that some researchers did a larger study in europe to see what DQ types they found, and they found celiacs without DQ2 or DQ8, and somehad half a gene.

I do not know how enterolab reports those with half a celiac gene.

It does look like some fficial celiacs are DQ1.

also, Hadjivassiliou found that about 20% og gluten ataxia patients have DQ1. Just type hadjivassiliou in www.pubmed.com or google.

nora