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Doubts About Tests

mom2lucas

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mom2lucas Rookie
mom2lucas
Posted

Hi! My 2 year old son was recently diagnosed a celiac through a biopsy, but his blood tests were negative. He started the gluten free diet almost a month ago and we are now seeing some improvements. However, we were waiting on our blood tests, because even though we didn't show any simptoms, my son's doctor ordered them anyway since this is an hereditary disease. We did IgA, Anti-TTG and Anti-endomysium, and they were all negative :huh: So, where did my son get it from? I know blood tests aren't reliable in kids, but I thought they were in adults, and even though we don't have any simptoms I guess my gallstones and psoriasis could be blamed on the celiac disease. Do you think this panel of blood tests is reliable or should we have the genetics tests done? Thanks for any input. :)

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psawyer Proficient
psawyer
Posted

The genetic factor alone does not create celiac disease. Many people have the gene without ever developing the autoimmune reaction.

It is generally understood that a trigger of some kind is needed to activate the disease in a person who is genetically susceptible. Obviously, gluten is also required for the reaction to occur--that is why the gluten-free diet works.

The trigger is usually something that puts stress on the immune system, such as an infectious disease, surgery or pregnancy/childbirth.

fedora Enthusiast
fedora
Posted

False negatives happen in adults too.

I have exzama. It is definately linked to wheat for me. I had to figure that out on my own.

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    • asaT
      nothing has changed

      By asaT · Posted

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    • nanny marley
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    • asaT
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    • par18
      Is it gluten?

      By par18 · Posted

      Scott, I agree with everything you said except the term "false negative". It should be a "true negative" just plain negative. I actually looked up true/false negative/positive as it pertains to testing. The term "false negative" would be correct if you are positive (have anti-bodies) and the test did not pick them up. That would be a problem with the "test" itself. If you were gluten-free and got tested, you more than likely would test "true" negative or just negative. This means that the gluten-free diet is working and no anti-bodies should be present. I know it sounds confusing and if you don't agree feel free to respond. 
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