Enterolab Results

[leadmeastray88]

I received my Enterolab results yesterday, here are the results:

A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value

Fecal Antigliadin IgA 11 (Normal Range <10 Units)

Fecal Antitissue Transglutaminase IgA 7 Units (Normal Range <10 Units)

Quantitative Microscopic Fecal Fat Score <300 Units (Normal Range <300 Units)

Fecal anti-casein (cow's milk) IgA antibody 7 Units (Normal Range <10 Units)

HLA-DQB1 Molecular analysis, Allele 1 0202

HLA-DQB1 Molecular analysis, Allele 2 0301

Serologic equivalent: HLA-DQ 2,3 (Subtype 2,7)

Interpretation of Fecal Antigliadin IgA: Intestinal antigliadin IgA antibody was elevated, indicating that you have active dietary gluten sensitivity. For optimal health, resolution of symptoms (if you have them), and prevention of small intestinal damage and malnutrition, osteoporosis, and damage to other tissues (like nerves, brain, joints, muscles, thyroid, pancreas, other glands, skin, liver, spleen, among others), it is recommended that you follow a strict and permanent gluten free diet. As gluten sensitivity is a genetic syndrome, you may want to have your relatives screened as well.

Interpretation of Fecal Antitissue Transglutaminase IgA: The level of intestinal IgA antibodies to the human enzyme tissue transglutaminase was below the upper limit of normal, and hence, there is no evidence of a gluten-induced autoimmune reaction.

Interpretation of Quantitative Microscopic Fecal Fat Score: Provided that dietary fat is being ingested, a fecal fat score less than 300 indicates there is no malabsorbed dietary fat in stool indicating that digestion and absorption of nutrients is currently normal.

Interpretation of Fecal anti-casein (cow's milk) IgA antibody: Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic "sensitivity" to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.

Interpretation Of HLA-DQ Testing: Although you do not possess the main HLA-DQB1 genes predisposing to celiac sprue (HLA-DQB1*0201 or HLA-DQB1*0302), HLA gene analysis reveals that you have two copies of a gene that predisposes to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having two copies of a gluten sensitive gene means that each of your parents and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity may be more severe.

Looks like my parents are a recipe for disaster!

Obviously I'm not having any malabsorption problems, no problem with casein, just elevated IgA with 2 copies of gluten sensitivity genes.

Any suggestions?

[ShayFL]

I say try the diet and see if the "proof is in the pudding".....gluten-free pudding of course.

The fact that you are reacting to gluten shows up. If you have symptoms, what do you have to lose?

[leadmeastray88]

Thanks for your input!

I have been on the gluten-free diet already for about a month (minus some mistakes).

Most of my symptoms have improved/disappeared, so I'm pretty confident in my decision.

I just wanted to see what others thought about these results.

[fedora]

Enterolab has it's own way of gene testing.

There are 2 parts to the gene, the alpha part and the beta part. Enterolab only tests for the beta part. In cases like yours I wish they tested that too.

so the whole celiac genes are DQ2(really DQ2.5) and DQ8.

HOWEVER, two other genes if both present in a person can come together and make the celiac gene DQ2.

These two genes are DQ2.2( your gene HLA-DQB1 Molecular analysis, Allele 1 0202 is it) and some of the DQ7 genes(your DQ7 gene HLA-DQB1 Molecular analysis, Allele 2 0301 MAY be the other).

There is only one DQ2.2 gene so it is always half of the gene. There are several DQ7 variations. Only one of them is the other half of the celiac gene.

Based on the info given your DQ7 may be the variation that is the other half of the celiac gene. The only way to know for sure is with genetic testing for the alpha part of the gene. Kimball tests for alpha parts too, but then it is more money.

I only have the DQ2.2 gene(the half) without the other half. I never had bloodwork or a biopsy. However, my results on the diet indicated that I was having an autoimmune reaction to it. My malabsorption test was negative, but I had symptoms of that too. I feel soooooo much better without gluten. My Dr seems okay with assuming I have an autoimmune reaction caused by gluten intolerance since it has helped me so much.

good luck and take care

[leadmeastray88]

Enterolab has it's own way of gene testing.

There are 2 parts to the gene, the alpha part and the beta part. Enterolab only tests for the beta part. In cases like yours I wish they tested that too.

so the whole celiac genes are DQ2(really DQ2.5) and DQ8.

HOWEVER, two other genes if both present in a person can come together and make the celiac gene DQ2.

These two genes are DQ2.2( your gene HLA-DQB1 Molecular analysis, Allele 1 0202 is it) and some of the DQ7 genes(your DQ7 gene HLA-DQB1 Molecular analysis, Allele 2 0301 MAY be the other).

There is only one DQ2.2 gene so it is always half of the gene. There are several DQ7 variations. Only one of them is the other half of the celiac gene.

Based on the info given your DQ7 may be the variation that is the other half of the celiac gene. The only way to know for sure is with genetic testing for the alpha part of the gene. Kimball tests for alpha parts too, but then it is more money.

I only have the DQ2.2 gene(the half) without the other half. I never had bloodwork or a biopsy. However, my results on the diet indicated that I was having an autoimmune reaction to it. My malabsorption test was negative, but I had symptoms of that too. I feel soooooo much better without gluten. My Dr seems okay with assuming I have an autoimmune reaction caused by gluten intolerance since it has helped me so much.

good luck and take care

Wow, what helpful information! Thank you so much.

That has peaked my curiosity, I'm going to look into the Kimball genetic testing.

Does anyone happen to have a link to the Kimball site, or where I could get more info?

-Kim

[fedora]

just google kimball gene testing.

Even without the full gene I have had such a positive recovery that I will not go back to eating gluten.

There are documented cases of people with celiac with only DQ2.2 or the DQ7 half gene and not with both. It is a very small number, but it has happened.

I will never know for sure and that is okay.

good luck