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Which Tests Should I Order, (ttg) Or (aga)?

dizzygrinch

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dizzygrinch Enthusiast
dizzygrinch
Posted

Hello, still researching on where to order tests. I found a website, direct labs, where I can order tests, and take the actual order to the lab near my home, in this case a labcorp, for testing. It sounds reasonable. They offer two different tests for celiac. One is the Tissue Transglutaminase Antibody Assay (tTG) and the other is the Anti-gliadin Antibody Assay (AGA). Can anyone help determine which test would be better? thanks in advance

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happygirl Collaborator
happygirl
Posted

tTG.

ravenwoodglass Mentor
ravenwoodglass
Posted

Have them do a complete panel, that would include both. If cost demands only one then do go with the Ttg. Do keep in mind though that the blood test does have false negatives, as does the biopsy so when you finish all your testing try the diet, strictly to see if it helps.

JennyC Enthusiast
JennyC
Posted

Total IgA

Ttg IgA

Ttg IgG

EMA (less accurate, but 100% specific for celiac)

Total blood count/chemistry

LDJofDenver Apprentice
LDJofDenver
Posted

I'm newly diagnosed (Aug 8 to be exact!) but here is what the University of Chicago Celiac Center says about testing:

"Which is the correct Screening Test?

Anti-Tissue Transglutaminase (tTG-IgA) -- A screening test is commonly used when an individual is in a risk group for Celiac Disease, whether or not he/she has symptoms. This test is usually the one offered for Celiac screening events, as it is the most sensitive test available. "

it lists other tests as well, and gives an explanation

here is a link to their website

Open Original Shared Link

Hope that helps, I know it can be overwhelming with all the information out there.

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    • trents
      Small Bowel Resection 12 inches

      By trents · Posted

      You might consider asking for a referral to a RD (Registered Dietician) to help with food choices and planning a diet. Even apart from any gluten issues, you will likely find there are some foods you need to avoid because of the shorter bowel but you may also find that your system may make adjustments over time and that symptoms may improve.
    • Ello
      Small Bowel Resection 12 inches

      By Ello · Posted

      I wish Dr’s would have these discussions with their patients. So frustrating but will continue to do research. Absolutely love this website. I will post any updates on my testing and results.  Thank you
    • trents
      Small Bowel Resection 12 inches

      By trents · Posted

      Losing 12" of your small bowel is going to present challenges for you in nutritional uptake because you are losing a significant amount of nutritional absorption surface area. You will need to focus on consuming foods that are nutritionally dense and also probably look at some good supplements. If indeed you are having issues with gluten you will need to educate yourself as to how gluten is hidden in the food supply. There's more to it than just avoiding the major sources of gluten like bread and pasta. It is hidden in so many things you would never expect to find it in like canned tomato soup and soy sauce just to name a few. It can be in pills and medications.  Also, your "yellow diarrhea, constipation and bloating" though these are classic signs of a gluten disorder, could also be related to the post surgical shorter length of your small bowel causing incomplete processing/digestion of food.
    • Ello
      Small Bowel Resection 12 inches

      By Ello · Posted

      Yes this information helps. I will continue to be pro active with this issues I am having. More testing to be done. Thank you so much for your response. 
    • trents
      Small Bowel Resection 12 inches

      By trents · Posted

      There are two gluten-related disorders that share many of the same symptoms but differ in nature from each other. One is known as celiac disease or "gluten intolerance". By nature, it is an autoimmune disorder, meaning the ingestion of gluten triggers the body to attack it's own tissues, specifically the lining of the small bowel. This attack causes inflammation and produces antibodies that can be detected in the blood by specific tests like the TTG-IGA test you had. Over time, if gluten is not withheld, this inflammation can cause severe damage to the lining of the small bowel and even result in nutrient deficiency related health issues since the small bowel lining is organ where all the nutrition found in our food is absorbed.  The other is NCGS (Non Celiac Gluten Sensitivity or just "gluten sensitivity") which we know less about and are unsure of the exact mechanism of action. It is not an autoimmune disorder and unlike celiac disease it does not damage the lining of the small bowel, though, like celiac disease, it can cause GI distress and it can also do other kinds of damage to the body. It is thought to be more common than celiac disease. Currently, we cannot test for NCGS. Celiac disease must first be ruled out to arrive at a diagnosis of NCGS. Both disorders require elimination of gluten from the diet.  Either of these disorders can find their onset at any stage of life. We know that celiac disease has a genetic component but the genes are inactive until awakened by some stress event. About 40% of the general population has the genetic potential to develop celiac disease but only about 1% develop active celiac disease. The incidence of NCGS is thought to be considerably higher. I hope this helps.
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