Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Is A Cure Coming?

Canadian Karen

By Canadian Karen
in Related Issues & Disorders

Recommended Posts

Canadian Karen Community Regular
Canadian Karen
Posted

This sounds really interesting. This company just got a huge grant to continue studying a cure for celiac. Sounds like they think they are on the right track....

...............................

Alba Therapeutics reports breakthrough diabetes results

Scientists at Alba Therapeutics Corporation and the University of Maryland School of Medicine have reported successful results from a study evaluating a zonulin agonist in type 1 diabetes.

Scientists at Alba Therapeutics Corporation and the University of Maryland School of Medicine have reported successful results from a study evaluating a zonulin agonist in type 1 diabetes.

The researchers reported a direct link between zonulin-mediated increased intestinal permeability and type 1 diabetes (T1D) in the BB/wor rat model of diabetes. The investigators were also able to successfully prevent the onset of the autoimmune destruction of pancreatic beta cells and the onset of T1D in these animals by using the specific zonulin blocker AT-1001.

Daily oral administration of the drug, beginning before the onset of auto-immunity in the diabetic prone rats, cut the incidence of the disease by two-thirds, and completely blocked the development of autoimmune antibodies in the treatment responders.

These results constitute the first successful result in preventing the autoimmune process characteristic of T1D by blocking the zonulin-mediated abnormal intestinal permeability.

"These results go well beyond the development of a prevention strategy for T1D," said Dr Alessio Fasano, professor of pediatrics, medicine and physiology at The University of Maryland School of Medicine. "They open a new field of investigation in which the interplay between host and environment at the mucosal level may help us understanding the molecular basis of many diseases."

"These results reinforce our conviction that the zonulin pathway provides a roadmap for the discovery and development of innovative products to treat many important diseases, including diabetes, in ways previously thought to be inconceivable" stated Dr Blake Paterson, CEO of Alba (LSE: ABA.L - news) .

Alba Therapeutics is a Baltimore-based biopharmaceutical company formed in 2004 and dedicated to commercializing disease-modifying therapeutics and drug delivery adjuvants based on the zonulin pathway. Alba's lead molecule, AT-1001, is targeted towards the treatment of celiac disease and type 1 diabetes and is in the final stages of pre-human testing.

...............................................

Let's keep our fingers crossed........

Karen

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Carriefaith Enthusiast
Carriefaith
Posted

That's great news Karen!

final stages of pre-human testing.

This means that in a few years (hopefully if the funding is good for these guys) we will know if there is a cure or a treatment plan for celiac! :D

celiac3270 Collaborator
celiac3270
Posted

On an NPR radio thing a few months ago, Dr. Green said that he expected a treatment for celiac within the next ten years--not actually a cure, but, for example, a pill so that if you accidentally ingest gluten, it won't do as much damage--that sort of thing.

But if we got that sooner....or by 2015 had something even better than treatment for accidents....wow. I tend to be skeptical about this sort of thing because I don't want to get my hopes up, but wouldn't that be cool? :)

flagbabyds Collaborator
flagbabyds
Posted

Actually at Stanford they are testing enzymes and and developing a pill that you can take, so it won't be a cure, but it will help us eat gluten more reguralraly

MySuicidalTurtle Enthusiast
MySuicidalTurtle
Posted

"Daily oral administration of the drug, beginning before the onset of auto-immunity in the diabetic prone rats, cut the incidence of the disease by two-thirds, and completely blocked the development of autoimmune antibodies in the treatment responders.""

So, since it is targeted agains diabetes and celiacs it would be preventing rather than curing.

This article makes me think it would be intended for children of people with Celiacs to prevent them from developing it, no?

I have heard what celiac3270 talked about as well as certain other things dpeending on which genes you have.

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. xxnonamexx
      - xxnonamexx replied to xxnonamexx's topic in Related Issues & Disorders
      5

      Self Diagnosed avoiding gluten 7 months later (Not tested due to eating gluten to test) update and question on soy

      I have heard about numerous food sensitivity tests blood and the prick and how nothing is very reliable I think trial and error probably best bet.
    2. trents
      - trents replied to xxnonamexx's topic in Related Issues & Disorders
      5

      Self Diagnosed avoiding gluten 7 months later (Not tested due to eating gluten to test) update and question on soy

      As ShariW explained, soy itself doesn't contain gluten but most soy sauces sold in stores and used in restaurants contain wheat as an ingredient so they are not gluten free. As I understand it, there are two traditional ways of making soy sauce. One way contains wheat and one doesn't. The most popular one found out there in the wild does contain wheat, however...
    3. trents
      - trents replied to kpf's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      6

      ttg iga high (646 mg/dl) other results are normal

      The IGA TTG (aka, TTG-IGA) is the centerpiece of celiac disease blood antibody testing. A high value in this test indicates probable celiac disease, though there are other reasons (some other diseases, some medications and in some cases, even some non-gluten foods that can cause it to be elevated. And it is not unusual at all for other celiac antibody tests...
    4. xxnonamexx
      - xxnonamexx replied to xxnonamexx's topic in Related Issues & Disorders
      5

      Self Diagnosed avoiding gluten 7 months later (Not tested due to eating gluten to test) update and question on soy

      Thanks that's what I didn't know about soy hidden with wheat. I know it's autoimmune but want sure about sensitivity to corn or eggs. There's no tests for these which are non gluten is there? I have had gluten free tortillas pastas made with corn and have had eggs so I don't think it bothers me but I was curious if there was a test that does sure sensitivities...
    5. kpf
      - kpf replied to kpf's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      6

      ttg iga high (646 mg/dl) other results are normal

      And of course I get these results (the ttg iga marked high at 646 mg/dL) on a Friday in my portal, my doctor wasn't in, and now we are in the weekend—leaving me to have to try and figure things out on my own until sometime next week. None of the nurses at the office would talk to me.
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,329
    • Most Online (within 30 mins)
      7,748
    solayrose
    Newest Member
    solayrose
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • xxnonamexx
      Self Diagnosed avoiding gluten 7 months later (Not tested due to eating gluten to test) update and question on soy

      By xxnonamexx · Posted

      I have heard about numerous food sensitivity tests blood and the prick and how nothing is very reliable I think trial and error probably best bet.
    • trents
      Self Diagnosed avoiding gluten 7 months later (Not tested due to eating gluten to test) update and question on soy

      By trents · Posted

      As ShariW explained, soy itself doesn't contain gluten but most soy sauces sold in stores and used in restaurants contain wheat as an ingredient so they are not gluten free. As I understand it, there are two traditional ways of making soy sauce. One way contains wheat and one doesn't. The most popular one found out there in the wild does contain wheat, however. Kikkoman offers a line of gluten-free soy sauce and Teriyaki products that are often sold by grocery store chains like Safeway. There are food allergy/food sensitivity tests available and your physician can order them or give you a referral. They fall into two categories, the skin prick kind and the blood test kind. One you might look into is called the ALCAT test which might be the most helpful for foods. However, the reliability of these things is questionable. The results can be helpful as a place to start but the results often don't match up with real life experience. There are reasons for this and you might do well to research food sensitivity testing reliability on the Internet. 
    • trents
      ttg iga high (646 mg/dl) other results are normal

      By trents · Posted

      The IGA TTG (aka, TTG-IGA) is the centerpiece of celiac disease blood antibody testing. A high value in this test indicates probable celiac disease, though there are other reasons (some other diseases, some medications and in some cases, even some non-gluten foods that can cause it to be elevated. And it is not unusual at all for other celiac antibody tests to be normal when the TTG-IGA is high. Normally, when the TTG-IGA is elevated, the physician will order an upper GI with biopsy of the small bowel lining to check for the damage characteristic of celiac disease. The biopsy is then sent out for microscopic analysis. This is to confirm the results of the blood testing and is considered the gold standard diagnostic test. You should not begin a gluten free diet until the endoscopy/biopsy is complete. This is very important because otherwise the results will be invalidated.  This article on celiac disease blood antibody tests might be helpful to you while you are waiting for feedback from the physician:  
    • xxnonamexx
      Self Diagnosed avoiding gluten 7 months later (Not tested due to eating gluten to test) update and question on soy

      By xxnonamexx · Posted

      Thanks that's what I didn't know about soy hidden with wheat. I know it's autoimmune but want sure about sensitivity to corn or eggs. There's no tests for these which are non gluten is there? I have had gluten free tortillas pastas made with corn and have had eggs so I don't think it bothers me but I was curious if there was a test that does sure sensitivities to these non gluten items for gluten-free people. Thanks
    • kpf
      ttg iga high (646 mg/dl) other results are normal

      By kpf · Posted

      And of course I get these results (the ttg iga marked high at 646 mg/dL) on a Friday in my portal, my doctor wasn't in, and now we are in the weekend—leaving me to have to try and figure things out on my own until sometime next week. None of the nurses at the office would talk to me. 
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.