Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.


  • Celiac.com Sponsor (A1):
    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Is A Cure Coming?

Canadian Karen

By Canadian Karen
in Related Issues & Disorders

Recommended Posts

Canadian Karen Community Regular
Canadian Karen
Posted

This sounds really interesting. This company just got a huge grant to continue studying a cure for celiac. Sounds like they think they are on the right track....

...............................

Alba Therapeutics reports breakthrough diabetes results

Scientists at Alba Therapeutics Corporation and the University of Maryland School of Medicine have reported successful results from a study evaluating a zonulin agonist in type 1 diabetes.

Scientists at Alba Therapeutics Corporation and the University of Maryland School of Medicine have reported successful results from a study evaluating a zonulin agonist in type 1 diabetes.

The researchers reported a direct link between zonulin-mediated increased intestinal permeability and type 1 diabetes (T1D) in the BB/wor rat model of diabetes. The investigators were also able to successfully prevent the onset of the autoimmune destruction of pancreatic beta cells and the onset of T1D in these animals by using the specific zonulin blocker AT-1001.

Daily oral administration of the drug, beginning before the onset of auto-immunity in the diabetic prone rats, cut the incidence of the disease by two-thirds, and completely blocked the development of autoimmune antibodies in the treatment responders.

These results constitute the first successful result in preventing the autoimmune process characteristic of T1D by blocking the zonulin-mediated abnormal intestinal permeability.

"These results go well beyond the development of a prevention strategy for T1D," said Dr Alessio Fasano, professor of pediatrics, medicine and physiology at The University of Maryland School of Medicine. "They open a new field of investigation in which the interplay between host and environment at the mucosal level may help us understanding the molecular basis of many diseases."

"These results reinforce our conviction that the zonulin pathway provides a roadmap for the discovery and development of innovative products to treat many important diseases, including diabetes, in ways previously thought to be inconceivable" stated Dr Blake Paterson, CEO of Alba (LSE: ABA.L - news) .

Alba Therapeutics is a Baltimore-based biopharmaceutical company formed in 2004 and dedicated to commercializing disease-modifying therapeutics and drug delivery adjuvants based on the zonulin pathway. Alba's lead molecule, AT-1001, is targeted towards the treatment of celiac disease and type 1 diabetes and is in the final stages of pre-human testing.

...............................................

Let's keep our fingers crossed........

Karen

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Carriefaith Enthusiast
Carriefaith
Posted

That's great news Karen!

final stages of pre-human testing.

This means that in a few years (hopefully if the funding is good for these guys) we will know if there is a cure or a treatment plan for celiac! :D

celiac3270 Collaborator
celiac3270
Posted

On an NPR radio thing a few months ago, Dr. Green said that he expected a treatment for celiac within the next ten years--not actually a cure, but, for example, a pill so that if you accidentally ingest gluten, it won't do as much damage--that sort of thing.

But if we got that sooner....or by 2015 had something even better than treatment for accidents....wow. I tend to be skeptical about this sort of thing because I don't want to get my hopes up, but wouldn't that be cool? :)

flagbabyds Collaborator
flagbabyds
Posted

Actually at Stanford they are testing enzymes and and developing a pill that you can take, so it won't be a cure, but it will help us eat gluten more reguralraly

MySuicidalTurtle Enthusiast
MySuicidalTurtle
Posted

"Daily oral administration of the drug, beginning before the onset of auto-immunity in the diabetic prone rats, cut the incidence of the disease by two-thirds, and completely blocked the development of autoimmune antibodies in the treatment responders.""

So, since it is targeted agains diabetes and celiacs it would be preventing rather than curing.

This article makes me think it would be intended for children of people with Celiacs to prevent them from developing it, no?

I have heard what celiac3270 talked about as well as certain other things dpeending on which genes you have.

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. suek54
      - suek54 replied to Kayla S's topic in Dermatitis Herpetiformis
      4

      Need advice for some relief!

      Hi Kayla Huge sympathies. I was diagnosed in December, after 8 months of the most awful rash, literally top to toe. Mine is a work in progress. Im on just 50mg dapsone at the moment but probably need an increased dose to properly put the lid on it. As you have been now glutened, I wondered whether it might be worth asking for a skin biopsy to finally...
    2. Scott Adams
      0

      Do Air Filters, Vent Hoods, and HEPA Vacuums Reduce Home Gluten Exposure?

    3. MicG
      - MicG replied to MicG's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      2

      Test interpretations

      I had been eating reduced gluten until about 3 days before the test. I did realize that wasn’t ideal, but it was experimental to see if gluten was actually bothering me. One slip up with soy sauce and it was quite clear to me that it was, lol.
    4. trents
      - trents replied to MicG's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      2

      Test interpretations

      Possibly. Your total IGA (Immunoglobulin A, Qn, Serum) is actually high so you are not IGA deficient. In the absence of IGA deficiency, the most reliable celiac antibody test would be the t-Transglutaminase (tTG) IgA for which your score is within normal range. There are other things besides celiac disease that might cause an elevated DGP-IGA (Deamidated...
    5. MicG
      - MicG posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      2

      Test interpretations

      Test results as follows: Deamidated Gliadin Abs, lgA 40 H (normal range 0-19) Deamidated Gliadin Abs, IgG 4 (0-19) t-Transglutaminase (tTG) IgA <2 (0-3) t-Transglutaminase (tTG) IgG <2 (0-5) Endomysial Antibody IgA Negative (Negative) Immunoglobulin A, Qn, Serum 535 H (87-352) Do I have celiac?
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      133,655
    • Most Online (within 30 mins)
      7,748
    Murdy3
    Newest Member
    Murdy3
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.6k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • suek54
      Need advice for some relief!

      By suek54 · Posted

      Hi Kayla Huge sympathies. I was diagnosed in December, after 8 months of the most awful rash, literally top to toe. Mine is a work in progress. Im on just 50mg dapsone at the moment but probably need an increased dose to properly put the lid on it. As you have been now glutened, I wondered whether it might be worth asking for a skin biopsy to finally get a proper diagnosis? Sue  
    • MicG
      Test interpretations

      By MicG · Posted

      I had been eating reduced gluten until about 3 days before the test. I did realize that wasn’t ideal, but it was experimental to see if gluten was actually bothering me. One slip up with soy sauce and it was quite clear to me that it was, lol. 
    • trents
      Test interpretations

      By trents · Posted

      Possibly. Your total IGA (Immunoglobulin A, Qn, Serum) is actually high so you are not IGA deficient. In the absence of IGA deficiency, the most reliable celiac antibody test would be the t-Transglutaminase (tTG) IgA for which your score is within normal range. There are other things besides celiac disease that might cause an elevated DGP-IGA (Deamidated Gliadin Abs, lgA) for which you do have a positive score. It might also be of concern that your total IGA is elevated as that can indicate some other health problems, some of which are serious.  Had you been practicing a gluten free or a reduced gluten free diet prior to the blood draw? Talk to your physician about these things. I would also seek an endoscopy/biopsy of the small bowel to check for damage to the villous lining, which is the gold standard diagnostic test for celiac disease.
    • MicG
      Test interpretations

      By MicG · Posted

      Test results as follows: Deamidated Gliadin Abs, lgA 40 H (normal range 0-19) Deamidated Gliadin Abs, IgG 4 (0-19) t-Transglutaminase (tTG) IgA <2 (0-3) t-Transglutaminase (tTG) IgG <2 (0-5) Endomysial Antibody IgA Negative (Negative) Immunoglobulin A, Qn, Serum 535 H (87-352) Do I have celiac?
    • catnapt
      how long does it take for the genetic blood test for celiac to come back?

      By catnapt · Posted

      how long does it take for the genetic blood test for celiac to come back? I saw the GI today, she was great. She says I def have an issue with gluten and that my symptoms align more with celiac disease than NCGS, so she's doing the genetic testing, Ordered a test for SIBO but said that's just to cover all bases, she doesn't think I have that. If the blood work comes back negative for the genes, then I will cancel the endoscopy. If positive, I will try the 2 week gluten challenge and get the endoscopy done. If I can't manage the gluten challenge (I had HORRIBLE symptoms last time and quit after 12 days) then we'll just assume it's celiac disease and go from there. She says she does a full nutrient panel on all her pts every year, that was nice to hear.I'm on so many supplements it would be nice to only have to get the ones I truly need! so yeh, really anxious about the test results for the genes!! I have an identical twin sister so I'd need to tell her if it's positive, she'd prob want to get tested too. *interesting note: when I said if the blood work comes back that I don't have the genes, then I'm in the clear - she said, well,,,,,,not necessarily. But she didn't want to go into as we had a lot to go over. I did make a  mental note of that comment and will ask her when I see her next time.   she was very thorough! I was impressed! she even checked- up on some lab work I had done that my Endo ordered. I like her, I am looking forward to seeing her again. I think I'll get some good advice and info from her she also complimented me on my diet.   said it was a very gut friendly and healthy diet 
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.