Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Is A Cure Coming?

Canadian Karen

By Canadian Karen
in Related Issues & Disorders

Recommended Posts

Canadian Karen Community Regular
Canadian Karen
Posted

This sounds really interesting. This company just got a huge grant to continue studying a cure for celiac. Sounds like they think they are on the right track....

...............................

Alba Therapeutics reports breakthrough diabetes results

Scientists at Alba Therapeutics Corporation and the University of Maryland School of Medicine have reported successful results from a study evaluating a zonulin agonist in type 1 diabetes.

Scientists at Alba Therapeutics Corporation and the University of Maryland School of Medicine have reported successful results from a study evaluating a zonulin agonist in type 1 diabetes.

The researchers reported a direct link between zonulin-mediated increased intestinal permeability and type 1 diabetes (T1D) in the BB/wor rat model of diabetes. The investigators were also able to successfully prevent the onset of the autoimmune destruction of pancreatic beta cells and the onset of T1D in these animals by using the specific zonulin blocker AT-1001.

Daily oral administration of the drug, beginning before the onset of auto-immunity in the diabetic prone rats, cut the incidence of the disease by two-thirds, and completely blocked the development of autoimmune antibodies in the treatment responders.

These results constitute the first successful result in preventing the autoimmune process characteristic of T1D by blocking the zonulin-mediated abnormal intestinal permeability.

"These results go well beyond the development of a prevention strategy for T1D," said Dr Alessio Fasano, professor of pediatrics, medicine and physiology at The University of Maryland School of Medicine. "They open a new field of investigation in which the interplay between host and environment at the mucosal level may help us understanding the molecular basis of many diseases."

"These results reinforce our conviction that the zonulin pathway provides a roadmap for the discovery and development of innovative products to treat many important diseases, including diabetes, in ways previously thought to be inconceivable" stated Dr Blake Paterson, CEO of Alba (LSE: ABA.L - news) .

Alba Therapeutics is a Baltimore-based biopharmaceutical company formed in 2004 and dedicated to commercializing disease-modifying therapeutics and drug delivery adjuvants based on the zonulin pathway. Alba's lead molecule, AT-1001, is targeted towards the treatment of celiac disease and type 1 diabetes and is in the final stages of pre-human testing.

...............................................

Let's keep our fingers crossed........

Karen

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Carriefaith Enthusiast
Carriefaith
Posted

That's great news Karen!

final stages of pre-human testing.

This means that in a few years (hopefully if the funding is good for these guys) we will know if there is a cure or a treatment plan for celiac! :D

celiac3270 Collaborator
celiac3270
Posted

On an NPR radio thing a few months ago, Dr. Green said that he expected a treatment for celiac within the next ten years--not actually a cure, but, for example, a pill so that if you accidentally ingest gluten, it won't do as much damage--that sort of thing.

But if we got that sooner....or by 2015 had something even better than treatment for accidents....wow. I tend to be skeptical about this sort of thing because I don't want to get my hopes up, but wouldn't that be cool? :)

flagbabyds Collaborator
flagbabyds
Posted

Actually at Stanford they are testing enzymes and and developing a pill that you can take, so it won't be a cure, but it will help us eat gluten more reguralraly

MySuicidalTurtle Enthusiast
MySuicidalTurtle
Posted

"Daily oral administration of the drug, beginning before the onset of auto-immunity in the diabetic prone rats, cut the incidence of the disease by two-thirds, and completely blocked the development of autoimmune antibodies in the treatment responders.""

So, since it is targeted agains diabetes and celiacs it would be preventing rather than curing.

This article makes me think it would be intended for children of people with Celiacs to prevent them from developing it, no?

I have heard what celiac3270 talked about as well as certain other things dpeending on which genes you have.

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. RMJ
      - RMJ replied to Midwesteaglesfan's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      5

      Going for upper endoscopy today

      I’m glad you have a clear answer. Some endoscopes have enough magnification for the doctor to see the damage during the procedure.
    2. Scott Adams
      - Scott Adams commented on Jefferson Adams's article in Gluten-Free Foods & Beverages
      13

      Top Brands of Gluten-Free Canned Chili

      While it seems unlikely to contain intentional gluten ingredients--and based on the ingredients you provided, this canned Wendy's chili appears to be gluten-free, but with a very important caveat: it cannot be considered certified or guaranteed gluten-free due to the potential for cross-contamination and the ambiguous nature of "natural flavors."
    3. Scott Adams
      - Scott Adams replied to Midwesteaglesfan's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      5

      Going for upper endoscopy today

      Welcome to the club!😉 This article has some detailed information on how to be 100% gluten-free, so it may be helpful (be sure to also read the comments section.):
    4. Scott Adams
      - Scott Adams replied to Butch68's topic in Gluten-Free Foods, Products, Shopping & Medications
      5

      Guinness, can you drink it?

      I could not find the thread, but I recall at least one user who was drinking regular gluten beer daily but getting celiac blood tests done often (I think it was monthly) and doing a biopsy each year and all celiac disease tests were always negative. Everyone is different, but in general regular beer would be considered low gluten (not gluten-free!). I have...
    5. maryannlove
      - maryannlove commented on Jefferson Adams's article in Gluten-Free Foods & Beverages
      13

      Top Brands of Gluten-Free Canned Chili

      I have same question as trents above. After I mentioned how much I liked Wendy's chili, a neighbor gave me a can b/c I didn't know could buy it in a can. Is gluten free in Wendy's restaurant, but can doesn't say gluten free so afraid to eat it. (Can says provides 50% Daily Value of protein, another plus.) Below are ingredients on can. Would the experts...
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,271
    • Most Online (within 30 mins)
      7,748
    NancyWM
    Newest Member
    NancyWM
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • RMJ
      Going for upper endoscopy today

      By RMJ · Posted

      I’m glad you have a clear answer.  Some endoscopes have enough magnification for the doctor to see the damage during the procedure.
    • Scott Adams
      Going for upper endoscopy today

      By Scott Adams · Posted

      Welcome to the club!😉 This article has some detailed information on how to be 100% gluten-free, so it may be helpful (be sure to also read the comments section.):    
    • Scott Adams
      Guinness, can you drink it?

      By Scott Adams · Posted

      I could not find the thread, but I recall at least one user who was drinking regular gluten beer daily but getting celiac blood tests done often (I think it was monthly) and doing a biopsy each year and all celiac disease tests were always negative. Everyone is different, but in general regular beer would be considered low gluten (not gluten-free!). I have no issues with Daura Damm, but those who are super sensitive might.
    • Aretaeus Cappadocia
      Gluten free nuts

      By Aretaeus Cappadocia · Posted

      Azure Standard (https://www.azurestandard.com/) is one of my gluten-free vendors. I've purchased nuts, "grains", flours, and many other products there. If you are not familiar with Azure, you have to set up an account (no cost) and get your purchases either via shipping (expensive) or "drop" (free if you buy a reasonable minimum). Search their website for a drop location in your area. Each drop location has a local volunteer(?) coordinator who coordinates with the local customers. I go to a drop 4-5 miles from my home that delivers every 2 weeks. We seem to range from 8-18 customers at a given delivery. The downside of the drop is that you have to be there when they say. They give you a few days notice of the precise time, though, and they are punctual. Their pricing relative to other vendors for various products ranges from best price to overpriced, so you have to shop and compare. Quality is mostly good but once in a while you get a dud - however they've been very responsive to giving me a credit on the few occasions when I've complained. In my opinion, they are not as transparent about gluten as they could be. Some products are labeled "gluten free" and so far I trust that. Many products are labeled "Azure Market products are re-packaged by Azure for your convenience in a facility that meets Food Safety Modernization Act (FSMA) standards, including an approved allergen control program." I've corresponded with them over this and they all but say this means gluten free. I've come to trust this, with a little nervousness, but I wish they would be more explicit. They also sell a lot of gluten-containing products. Frankly, I think they are overlooking a business opportunity to become a trusted source for the gluten-free community by not being more clear about gluten. Among Azure products I've purchased are "Walnuts, Baker's Pieces, Raw", "Cashews, Raw, Large White Pieces, Organic" and "Missouri Northern Pecan Grower Pecans Fancy Native, Raw, Halves". The walnuts and cashews were very good and the pecans were fabulous. For almonds, I've been buying Blue Diamond unsalted when they go on sale (mostly from Safeway). The salted ones are probably fine too but the flavored ones I avoid now that I am gluten-free. I also buy products including nuts from CostCo (cashews, shelled pistachios). Their nuts usually contain a "made in a facility that processes wheat" statement, which is scary. I've contacted customer service about various Kirkland products and they will usually give you a response <<for a specific lot>> whether it really was made in a wheat facility (sometimes yes sometimes no). For the "Kirkland Signature Fancy Whole Cashews, Unsalted, 40 oz" and "Kirkland Signature Shelled Pistachios, Roasted & Salted, 1.5 lbs", I got a "safe" answer and I ate them. I got an "unsafe" answer once for "Kirkland Signature Fancy Whole Cashews with Sea Salt, 2.5 lbs" and "Kirkland Signature Dry Roasted Macadamia Nuts, Salted, 1.5 lbs" and I don't look at these anymore. Again, these answers were given for specific lots only. They will accept an unopened return for cash if you find out you don't want it. Costco also sells "Kirkland Signature Super Extra-Large Peanuts, 2.5 lbs" that are labeled gluten free. My celiac kid eats them all the time. I pretty much only eat food that I prepare myself from scratch. My celiac symptoms are not that overt, so I can't say for certain I could identify a glutening. However, my antibody levels dropped 25 fold (into normal range) since my dx earlier this year. Hope this helps.
    • Jmartes71
      Related issues

      By Jmartes71 · Posted

      Doterra literally has saved my life hands down.Nateral supplements that really are pure grade and does work organically with ones body. I had to stop all my nateral supplements to be a good puppet for medical so I can get the financial help that my body won't allow me to do more days than not these days, every day with menopause.....Not feeling well.Had to switch " medical team" because I was told I wasn't celiac though I am gluten-free since 1994! I am also positive HLA-DQ2. I think doctors down play it because on quest lab work it states " However 39% of the U.S  general population carry these HLA-DQ variants, as a consequence, the presence of HLA-DQ2 or  DQ8 or both variants is not perse diagnostic of celiac disease". Hintz the down playing of celiac disease......This needs to change because doctors seem to down playe it because when I showed the past 2nd and 3rd  doctors that I waisted my time on this year showed my that line and absolutely down played it.4th pcp this year.I live in Patterson California and would love for a few of us to go to mayors office and make this disease heard
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.