Question Bout Gluten Intolerance

[jasonD2]

Is it possible to not have celiacs but be gluten intolerant with elevated gliadin antibodies. in other words if you have elevated gliadin antibodies does that always mean celiacs or can it also be indicative of an intolerance?

[happygirl]

It can indicate either.

[cruelshoes]

Anti Gliadin antibodies can indicate gluten intolerance related to celiac, can indicate gluten intolerance that is not celiac, and can indicate an unrelated condition altogether.

Open Original Shared Link

Antigliadin antibodies may be present in inflammatory bowel disease [39], collagen vascular disease [40], and in many healthy people as well [41].

Here is another link you may find interesting.

https://www.celiac.com/articles/57/1/Interp...ults/Page1.html

Both IgA and IgG anti-gliadin antibodies (AGA) are detected in sera of patients with gluten sensitive enteropathy (celiac disease). IgG anti-gliadin antibodies are more sensitive but are less specific markers for disease compared with IgA class antibodies. IgA anti-gliadin antibodies are less sensitive but are more specific. In clinical trials, the IgA antibodies have a specificity of 97% but the sensitivity is only 71%. That means that, if a patient is IgA positive, there is a 97% probability that they have celiac disease. Conversely, if the patient is IgA negative, there is only a 71% probability that the patient is truly negative for celiac disease. Therefore, a positive result is a strong indication that the patient has the disease but a negative result does not necessarily mean that they don not have it. False positive results are rather uncommon but false negative results can occur. On the other hand, the IgG anti-gliadin antibodies are 91% specific and have an 87% sensitivity. This means that they will show positive results more readily but there is not as strong a correlation with celiac disease. It is less specific. Patients with other conditions but not afflicted with celiac disease will occasionally show positive results. IgG anti-gliadin antibodies are detectable in approximately 21% of patients with other gastrointestinal disorders. This test might yield false positive results but is less likely to yield false negative results.