Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Dna Results In

angelschick

Recommended Posts

angelschick Apprentice
angelschick
Posted

I just got my genetic test in and I am very confused. Can somone explain this to me in English?

HLA-DQB1 Molecular analysis, Allele 1 0501

HLA-DQB1 Molecular analysis, Allele 2 0604

Serologic equivalent: HLA-DQ 1,1 (Subtype 5,6)

So if hubby is reading this right, I do not possess the gene for celiac. Am I in the clear then and just have a sensitivity?

Confused as usual....

Amy

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Mother of Jibril Enthusiast
Mother of Jibril
Posted

Hi Amy,

Your husband is right that you don't have one of the main genes for celiac disease (DQ2 or DQ8). However... you do have a double dose of serotype DQ1 (you have a combination of subtypes DQ5 and DQ6). Serotype DQ1 is associated with neurological problems such as ataxia, MS, vertigo, depression, etc...

Wikipedia (Open Original Shared Link) says that DQ5 gives protection against Addisons's disease (this is a good thing!), but makes you susceptible to aneurysms, IBS, Chron's disease, and intolerance to analgesics (pain medications).

Hope this helps!

angelschick Apprentice
angelschick
Posted
  • Author
Hi Amy,

Your husband is right that you don't have one of the main genes for celiac disease (DQ2 or DQ8). However... you do have a double dose of serotype DQ1 (you have a combination of subtypes DQ5 and DQ6). Serotype DQ1 is associated with neurological problems such as ataxia, MS, vertigo, depression, etc...

Wikipedia (Open Original Shared Link) says that DQ5 gives protection against Addisons's disease (this is a good thing!), but makes you susceptible to aneurysms, IBS, Chron's disease, and intolerance to analgesics (pain medications).

Hope this helps!

It does help but now I'm even more confused. I was *SURE* I had celiac disease but the genetics say otherwise. So why would a non-celiac's LOW cholesterol finally go up after going gluten-free? I just don't understand......

Mother of Jibril Enthusiast
Mother of Jibril
Posted

You could be one of those rare people that has celiac disease without DQ2 or DQ8... check out the profile of ravenwoodglass.

Also... you don't need to have celiac disease to have problems with malabsorption. Look at some websites about Chron's, for example. That's another autoimmune disorder that affects the intestines and interferes with proper digestion. If you feel better being off gluten, then do that! Nobody says you have to eat it ;)

ravenwoodglass Mentor
ravenwoodglass
Posted

The lack of DQ2 or DQ8 is not conclusive in the elimination of the possibility of having celiac. Those are the most common ones, as far as US is concerned, but there are now 7 more genes that are recognized as being 'celiac' genes in other countries. You can definately still have full blown celiac.

Jestgar Rising Star
Jestgar
Posted
It does help but now I'm even more confused. I was *SURE* I had celiac disease but the genetics say otherwise. So why would a non-celiac's LOW cholesterol finally go up after going gluten-free? I just don't understand......

The "Celiac genes" have not been shown to cause Celiac. They are only markers. If you don't have the marker, that doesn't mean that you don't have the genes(s) that cause Celiac.

fedora Enthusiast
fedora
Posted

just curious,

what are your symptoms?

I aske because those are my daughter's genes

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


angelschick Apprentice
angelschick
Posted
  • Author

I saw an "allergist" today who specializes in and HAS celiac. She says best case scenario I have a bad gluten sensitivity, maybe even celiac. She said my genes alone cannot rule out celiac. So - she has ordered a biopsy and a full celiac panel.I will know Monday when it is.

Fedora - my symptoms are - PAIN (LOTS of it) in mostly back and left hip but all joints, exhausted, LOW cholesterol (that went up when I went gluten-free for a few weeks), bloating, D which is fatty (YUCK!), Constipated, gas, my fingers and toes are often numb, no hormones to speak of, odd red rash (NON-DH) under my chin, hashimoto's, always hungry, high heart rate (resting in 90's), carpel tunnel, get dizzy when i stand up at times.

  • 2 weeks later...
glutenfreemaryland Newbie
glutenfreemaryland
Posted

The enterolab webpage has lots of information on understanding gene testing. The gene testing results are most useful if the result is that you do not possess the genes associated with celiac - then I believe that means you are in the clear. When my daughter was tested b/c I have celiac disease, we found she has two genes associated with celiac disease. According to enterolab and her doctor, all this means is that there is a chance that she may develp celiac disease someday. Many people with the genes never develop it. We would told to just have her primary physician order the blood test every two years.

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. marlene333
      - marlene333 replied to Grace Good's topic in Gluten-Free Foods, Products, Shopping & Medications
      3

      Bee balm lipbalm not gluten free

      To play it safe, use Vasoline Lip Therapy. No questions as to it containing gluten.
    2. Mari
      - Mari replied to Jmartes71's topic in Coping with Celiac Disease
      4

      Related issues

      jmartes, Thank you for sharing more information with us. Most of us Celiacs whose problems do not clear up with in a few years have to decide what to do next. We can keep seeing DR.s and hope that we will get some medication or advice that will improve our health. Or we can go looking for other ways to improve our health. Usually Celiac Disease is...
    3. Scott Adams
      - Scott Adams replied to catsrlife's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      4

      Patiently Waiting to See Results

      It's unfortunate that they won't work with you on this, but in the end sometimes we have to take charge of our own health--which is exactly what happened to me. I did finally get the tests done, but only after years of going down various rabbit holes and suffering. Just quitting gluten may be the best path for you at this point.
    4. catsrlife
      - catsrlife replied to catsrlife's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      4

      Patiently Waiting to See Results

      My doctor didn't take the time to listen to anything. I don't even think she knows what it means. She is more concerned about my blood pressure that is caused by her presence than anything else and just wants to push pills at me. The so-called dermatologist wouldn't do a skin test. she prescribed all of these silly antihistamine skin meds. This lady...
    5. Jmartes71
      - Jmartes71 replied to Jmartes71's topic in Coping with Celiac Disease
      4

      Related issues

      I had the test done by one of the specialist through second pcp I had only a few months because he was saying I wasn't.Even though Im positive HLA-DQ2 .My celiac is down played.I am with new pcp, seeing another girl doctor who wants to do another breathe test next month though Im positive sibo this year.I have high blood pressure not sure if its pain from...
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,263
    • Most Online (within 30 mins)
      7,748
    Elyn Joy
    Newest Member
    Elyn Joy
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Who's Online (See full list)

  • Upcoming Events

  • Posts

    • marlene333
      Bee balm lipbalm not gluten free

      By marlene333 · Posted

      To play it safe, use Vasoline Lip Therapy. No questions as to it containing gluten.
    • Mari
      Related issues

      By Mari · Posted

      jmartes, Thank you for sharing  more information with us. Most of us Celiacs whose problems do not clear up with in a few years have to decide what to do next. We can keep seeing DR.s and hope that we will get some  medication or advice that will improve our health. Or we can go looking for other ways to improve our health. Usually Celiac Disease is not a killer disease, it is a disabling disease as  you have found out. You have time to find some ways to help you recover. Stay on your gluten-free diet and be more careful in avoiding cross contamination . KnittyKitty  and others here can give you advice about avoiding some foods that can give you the gluten auto immune reaction and advice about vitamins and supplement that help celiacs. You may need to take higher doses of Vit. B12  and D3.  About 20 years before a Dr. suggested I might have Celiac disease I had health problems that all other Dr said they could not identify or treat. I was very opposed to alternative providers and treatments. So many people were getting help from a local healer I decided to try that out. It was a little helpful but then, because I had a good education in medical laboraties she gave me a book  to read and what did I think. With great skeptism I started reading and before I was half way through it I began using the methods outlined in the book. Using those herbs and supplements I went from hardly able to work to being able to work almost fulltime. I still use that program. But because I had undiagnosed celiac disease by 10 years later some  of my problems returned and I started to loose weight.    So how does a person find a program that will benefit them? Among the programs you can find online there are many that are snake oil scams and some that will be beneficial. by asking around, as I did. Is there an ND in your area? Do they reccomend that person? If you would like to read about the program I use go to www.drclark.net   
    • Scott Adams
      Patiently Waiting to See Results

      By Scott Adams · Posted

      It's unfortunate that they won't work with you on this, but in the end sometimes we have to take charge of our own health--which is exactly what happened to me. I did finally get the tests done, but only after years of going down various rabbit holes and suffering. Just quitting gluten may be the best path for you at this point.
    • catsrlife
      Patiently Waiting to See Results

      By catsrlife · Posted

      My doctor didn't take the time to listen to anything. I don't even think she knows what it means. She is more concerned about my blood pressure that is caused by her presence than anything else and just wants to push pills at me. The so-called dermatologist wouldn't do a skin test. she prescribed all of these silly antihistamine skin meds. This lady didn't even know what she was talking about and said "they never turn out as celiac, they usually just say it's dermatitis so here's your meds," just like my regular quack. I'm trying to change insurance companies at the moment and that has been a battle because of red tape, wrong turns, and workers having wrong phone numbers. What a joke! The allergy blood days say I have a wheat allergy of .31. Hopefully it's just that and until I find a decent doctor and dermatologist, I'll just lay off the wheat anyway, since it gives me asthma, high blood sugar, and joint pain. So frustrated at this point. The rash on my back of arms/elbows is mostly gone. Both calves and chest have started up. smh. It comes and goes. It fades faster now, though, although my forearms still produce one or two bumps on each side. The itching has calmed down a lot except for the bump area. I have dry skin to begin with so anything affecting it just makes it crazy. i'm never going to eat wheat again. I don't care if they need it to produce results or if it is just an intolerance, allergy, or celiac. It gives me hell.
    • Jmartes71
      Related issues

      By Jmartes71 · Posted

      I had the test done by one of the specialist through second pcp I had only a few months because he was saying I wasn't.Even though Im positive HLA-DQ2 .My celiac is down played.I am with new pcp, seeing another girl doctor who wants to do another breathe test next month though Im positive sibo this year.I have high blood pressure not sure if its pain from sciatica or sibo, ibs or hidden gluten. Im in disability limbo and I should have never been a bus driver because im still suffering and trying to heal with zero income except for my husband. This isnt fare that my health is dictating my living and having ti beg for being revalidation of my disregarded celiac disease. Its an emotional roller coaster I don't want to be on and the medical made it worse.New pcp new gi, exhausted, tired and really fed up. GI doctor NOT girl..
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.