I Ordered My Hla Test Last Night!

[caek-is-a-lie]

I got my tax return yesterday, so I did what I promised myself I'd do and went to the Enterolab site to order my HLA test. I'm just testing myself for starters and might test my son at a later date depending on the results of this one. I'm so excited! I can't wait to see the results. It can't be negative...there's too much that runs in our family. I'm really hoping it validates some of my suspicions.

[Mother of Jibril]

Cool! I look forward to reading your results. DQ7.3 is associated with narcolepsy... so I'll be very curious to see if that turns up

[caek-is-a-lie]

The "Narcolepsy gene" that Stanford discovered is DQB1*0602. I have read that DQB1*0603 is associated with gluten intolerance, and it is only one nucleotide different. Have you heard that? Because they did a study where 28% of Narcoleptics they screened had the *0603 variant and there are quite a few of us that are symptom free on a gluten-free diet. My dream is to go to grad school and do a clinical study of gluten intolerance in Narcoleptics. I know it will help a lot of people...if I could just get accepted to a school...lol. At this rate I'm sure someone will beat me to it, but I can still fantasize, can't I?

Do you have a link to somewhere where I can read more about DQ7.3? I'm still kind of an HLA noob. My specialty is more neuroscience and neuroendocrinology.

[caek-is-a-lie]

Here's the results!

HLA-DQB1 Molecular analysis, Allele 1 0202

HLA-DQB1 Molecular analysis, Allele 2 0301

Serologic equivalent: HLA-DQ 2,3 (Subtype 2,7)

I've done some research and 0301 is implicated in Narcolepsy, too, which I have. This totally validates everything I've hypothesized about my own health. Gluten triggers my Narcolepsy symptoms and now maybe I have the answer as to why. If I'm reading this right, I have 2 copies of 0301. Am I reading this right? They said in the analysis that I have 2 copies of one of these genes, and I can only guess it's the one next to "Allele 2".

Thanks for any input. I'm sooooo happy! I've been shunned from some Narcolepsy circles because I don't have the other, more prevalent gene, DQB1*0602. But it turns out I really do have a Narcolepsy gene...that doubles as a gluten intolerance gene. Yaaaay! Answers!!

[Mother of Jibril]

I've done some research and 0301 is implicated in Narcolepsy, too, which I have. This totally validates everything I've hypothesized about my own health. Gluten triggers my Narcolepsy symptoms and now maybe I have the answer as to why. If I'm reading this right, I have 2 copies of 0301. Am I reading this right?

That's awesome!! I know how good it feels to have some answers

So... you have one copy of DQ2 (the major one connected with celiac disease) and one copy of DQ7. I have a mixed HLA-DQ genotype too (DQ7, DQ8) and I suspect that's why my allergies are so bad. It's easy to develop allergies when your intestines are damaged by celiac disease... but I was already predisoposed to allergies because of the DQ7 gene. Argh