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Interpreting Hla Results

eliza9

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eliza9 Newbie
eliza9
Posted

I have been reading around about HLA results, but I am still confused as to how to interpret mine as they are from Quest. If anyone has any resources that they could direct me to, that would be fantastic. For the heck of it, I'll post my results, in case anyone has any insight...

HLA-DQ2 (DQA*05/DQB1*02) Negative

HLA-DQ8 (DQA*03/DQB1*0302) Negative

HLA-DQA1* 02

HLA-DQA1* 03

HLA-DQB1* 0202

HLA-DQB1* 0301

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Mother of Jibril Enthusiast
Mother of Jibril
Posted

Hi Eliza9,

A good place to start is the Wikipedia page on HLA-DQ:

Open Original Shared Link

You have DQ2.2 and DQ7.3. Neither one is an official "celiac" gene (meaning your chance of having autoimmune damage to your intestines is greatly reduced), but both genes are associated with gluten sensitivity. So... have you tried the gluten-free diet? How do you feel?

Incidentally, DQ7.3 is also associated with lupus (SLE), thyroid disorders, narcolepsy, gingival disease, antiphospholipid syndrome, and hypersensitivity to the proteins in dairy products. You can find a lot of information by searching google for your specific genes, for example...

Open Original Shared Link

Keep in mind that having the gene does NOT mean you have the disease. It just means that your risk is higher than the average person.

eliza9 Newbie
eliza9
Posted
  • Author

Thanks so much for this! Looks like I've got some reading to do...

Yes, I've been on a gluten free diet for about a year now, and it's like night and day. I feel like a completely different person, and most of my mystery gastrointestinal issues have resolved. Whenever I've introduced it back in, either purposefully, or accidentally, I've had pretty severe reactions.

I had this HLA typing done about a year ago, after I started restricting my diet. When I saw that I was negative for DQ2 and DQ8 I figured that I must not have celiacs. But it's been perplexing, as I definitely have serious reactions, and the diet has clearly made such a difference, and so I started to take another look at my results...

As for DQ7.3, thyroid disorders and dairy issues (I think I'm included in this) run in my family. No narcolepsy that I know of...

Thanks again, and I'll be looking into all of this...

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      By olivia11 · Posted

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    • knitty kitty
      GI DX celiac despite neg serology and no biopsy

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