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Blood Test


dube

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dube Contributor

My bloodtest came out Negative...however I was off gluten for 6 weeks, not knowing you had to be on it. My doctor said go back onto Gluten and take it again. Feeling great for 6 weeks...had three pieces of pizza 2 days ago and now have the runs from hell and my stomach hurts...Anyway, my question is: I know you should be on gluten for three months before the biopsy..what about the bloodwork? Would a week be fine? Or can I just go and eat wheat pasta and a hoagie 1 to 2 days before the bloodwork???

Thanks guys.


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Mari Enthusiast

People have differing opinions about eating gluten just because their Dr wants to confirm his diagnosis. Some do it but many of us don't want to become ill again so refuse. When my blood tests came back they showed elevated alpha gliadin but a negative tissue transglutaminase. This confused my Dr but I felt so much better even after a week on the gluten-free diet I decided to have the genetic test done. The lab I used, not the one advertized at Celiac.com, showed I was DQ2/DQ2 and had a high risk of developing celiac disease. That was enough confirmation for me, I had the symptoms, did better on a gluten-free diet and will be gluten-free for the rest of my life. This lab also offers fecal tests for the antibodies which are much more sensitive than the blood tests, and fecal tests for food allergies and to assess the maladsorbtion problem. Dr. Fine who runs this lab has Celiac Disease and is considered an authority on celiac disease.

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    • nanny marley
      I agree there I've tryed this myself to prove I can't eat gluten or lactose and it sets me back for about a month till I have to go back to being very strict to settle again 
    • trents
      You may also need to supplement with B12 as this vitamin is also involved in iron assimilation and is often deficient in long-term undiagnosed celiac disease.
    • trents
      @par18, no, Scott's use of the term "false negative" is intentional and appropriate. The "total IGA" test is not a test used to diagnose celiac disease per se. The IGA immune spectrum response encompasses more than just celiac disease. So, "total IGA" refers to the whole pie, not just the celiac response part of it. But if the whole pie is deficient, the spectrum of components making it up will likely be also, including the celiac disease response spectrum. In other words, IGA deficiency may produce a tTG-IGA score that is negative that might have been positive had there not been IGA deficiency. So, the tTG-IGA negative score may be "false", i.e, inaccurate, aka, not to be trusted.
    • RMJ
      This may be the problem. Every time you eat gluten it is like giving a booster shot to your immune system, telling it to react and produce antibodies again.
    • asaT
      Scott, I am mostly asymptomatic. I was diagnosed based on high antibodies, low ferritin (3) and low vitamin D (10). I wasn't able to get in for the biopsy until 3 months after the blood test came back. I was supposed to keep eating gluten during this time. Well why would I continue doing something that I know to be harmful for 3 more months to just get this test? So I did quit gluten and had the biopsy. It was negative for celiacs. I continued gluten free with iron supps and my ferritin came back up to a reasonable, but not great level of around 30-35.  Could there be something else going on? Is there any reason why my antibodies would be high (>80) with a negative biopsy? could me intestines have healed that quickly (3 months)?  I'm having a hard time staying gluten free because I am asymptomatic and i'm wondering about that biopsy. I do have the celiacs gene, and all of the antibody tests have always come back high. I recently had them tested again. Still very high. I am gluten free mostly, but not totally. I will occasionally eat something with gluten, but try to keep to a minimum. It's really hard when the immediate consequences are nil.  with high antibodies, the gene, but a negative biopsy (after 3 months strict gluten-free), do i really have celiacs? please say no. lol. i think i know the answer.  Asa
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