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Confusing Blood Tests


Klo123

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Klo123 Newbie

I recently had my 6 year old daughter tested for Celiac due to family history (myself, my sister, and my uncle) and her constant complaints of her stomach aching as well as some fatigue (she would sleep for 13+ hours once a week or so). Her blood tests results are listed below:

Gliadin IGG 13.7 (<10 is normal according to lab) POSITIVE

Gliadin IGA 0.9 (<5 is normal) NEGATIVE

TTG IGG 7.1 (6-9 is a weak positive) POSITIVE

TTG IGA 1.6 (<4 is negative) NEGATIVE

Both IGG were positive and both IGA were negative. Her regular pediatrician said yes she has it, so we started her on a gluten free diet. It has been less than a week so it is hard to tell if it is working. We DO NOT want to do a biopsy on her. I have asked for a referral to a GI, but I know she will have to be back on gluten before going. I guess I was just wondering if anyone could shed some light on the confusing blood tests. Does it seem like she has? Why are her IGA levels so low?


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Jestgar Rising Star

It may be that she's IgA deficient. They could test total IgA and tell you for sure.

ravenwoodglass Mentor

It may be that she's IgA deficient. They could test total IgA and tell you for sure.

That is quite possible, did they do a total IGA?

Also if you are going to do more testing you need to keep her on gluten. If you are not going to biopsy then go ahead and get her on the diet strictly but keep in mind that when she gets to the GI any tests he does will be negative if she is on the diet already.

Also with those positive results it is a good idea to have everyone in the family screened.

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    • Fayeb23
      Thank you that’s really helpful, hopeful won’t have to have a biopsy.
    • RMJ
      That means the normal range (i.e. not celiac disease) would be a result less than 14.99.  Your result is WAY above that. Some gastroenterologists would diagnose that as celiac disease even without a confirming biopsy because it is more than ten times the top of the normal range.
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      Thank you. These were the results TTG ABS NUMERICAL: > 250.0 U/mL [< 14.99]  Really don’t understand the results!
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      Clearly from what you've said the info on Dailymed is much more up to date than the other site, which hasn't been updated since 2017. The fact that some companies might be repackaging drugs does not mean the info on the ingredients is not correct.
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