Jump to content
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

High Igg Test - What Next?


Pal Mom

Recommended Posts

Pal Mom Newbie

My daughter is 6 years old. She was born 8 weeks premature, but was born relatively healthy and has met all "normal" milestones throughout her six years.

She always complains of her tummy hurting and she suffers from constipation and occasional leg cramping (related?!). Her doctor ran several tests. The IgG test results came back high.

I have not heard from her doctor yet regarding these tests (they were emailed from the lab), so I am hoping to gather a little bit of information about them before she calls. Does the high IgG test mean she should have other tests done? I have read about a biopsy? Is it too soon to consider something like that or is that the next step? All the other tests were normal, with the exception of her free T4 test. The result for free T4 was slightly high. Two of her test results are below.

Antigliadin IgA Antibody = 3

Unit: U/mL

Reference Range:

NEGATIVE: <11

EQUIVOCAL: 11-17

POSITIVE: >17

Antigliadin IgG Antibody = 90

Unit: U/mL

Reference Range:

NEGATIVE: <11

EQUIVOCAL: 11-17

POSITIVE: >17


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



Skylark Collaborator

She should have been tested for total IgA and TTG IgA as part of a celiac panel. How did those look? Celiac is not diagnosed from anti-gliadin IgG unless the person is IgA deficient overall.

It does mean she might be sensitive to gluten, but don't try the diet until all the testing is done. The gluten-free diet makes the tests inaccurate.

Pal Mom Newbie

Here are two of her other tests. They were both in the normal range. I had heard that IgA might be low in children. Is that correct?

TTG IgA Antibody = <3

Unit: U/mL

Reference Range:

NEGATIVE: <5

EQUIVOCAL: 5-8

POSITIVE: >8

IgA = 69

28-180 mg/dL

Skylark Collaborator

Here is information on the IgG with normal IgA. Basically it's not a celiac result.

Open Original Shared Link

Let your doctor finish ruling out other problems, and decide whether he wants to do an endoscopy. He may want to have a look anyway. Once the testing is done, you can try the gluten-free diet and also screen her for other food allergies.

SGWhiskers Collaborator

Skylark,

Thank you for that link. One of my tests keeps coming back high dispite the gluten-free diet. Once I look back at my records, I'll be able to use that site to help me figure out what else to request testing for.

  • 10 months later...
milkmommy Apprentice

I realize this thread is old but I was wondering if you found out what was wrong with your child? My 2 year old has the same symptoms and high igg

Archived

This topic is now archived and is closed to further replies.


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      132,202
    • Most Online (within 30 mins)
      7,748

    PatBurnham
    Newest Member
    PatBurnham
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • trents
      NCGS does not cause damage to the small bowel villi so, if indeed you were not skimping on gluten when you had the antibody blood testing done, it is likely you have celiac disease.
    • Scott Adams
      I will assume you did the gluten challenge properly and were eating a lot of gluten daily for 6-8 weeks before your test, but if not, that could be the issue. You can still have celiac disease with negative blood test results, although it's not as common:  Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606118/  Seronegative Celiac Disease - A Challenging Case: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441776/  Enteropathies with villous atrophy but negative coeliac serology in adults: current issues: https://pubmed.ncbi.nlm.nih.gov/34764141/  Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.
    • Xravith
      I'm very confused... My blood test came out negative, I checked all antibodies. I suppose my Total IgA levels are normal (132 mg/dl), so the test should be reliable. Still, I'm not relieved as I can't tolerate even a single biscuit. I need to talk to my doctor about whether a duodenal biopsy is necessary. But it is really possible to have intestinal damage despite having a seronegative results? I have really strong symptoms, and I don't want to keep skipping university lectures or being bedridden at home.
    • Scott Adams
      They may want to also eliminate other possible causes for your symptoms/issues and are doing additional tests.  Here is info about blood tests for celiac disease--if positive an endoscopy where biopsies of your intestinal villi are taken to confirm is the typical follow up.    
    • Scott Adams
      In the Europe the new protocol for making a celiac disease diagnosis in children is if their tTg-IgA (tissue transglutaminase IgA) levels are 10 times or above the positive level for celiac disease--and you are above that level. According to the latest research, if the blood test results are at certain high levels that range between 5-10 times the reference range for a positive celiac disease diagnosis, it may not be necessary to confirm the results using an endoscopy/biopsy: Blood Test Alone Can Diagnose Celiac Disease in Most Children and Adults TGA-IgA at or Above Five Times Normal Limit in Kids Indicates Celiac Disease in Nearly All Cases No More Biopsies to Diagnose Celiac Disease in Children! May I ask why you've had so many past tTg-IgA tests done, and many of them seem to have been done 3 times during short time intervals?    
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.