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Low Iga And Neg Test Results

lost4o4

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lost4o4 Newbie
lost4o4
Posted

My symptoms:

wake up nearly every morning with abdominal pain, bloating, gas, occasional nausea

-occurs later on in the day after eating as well

Tests:

Total IgA= Low

IgG= negative for celiac

I'm really frustrated and don't know what to do next. I just want someone to tell me exactly what's wrong and be 100% sure. I've considered trying to eat gluten free and see how I feel, I just would really like to know for sure before I change my whole lifestyle.

Any advice/suggestions would be greatly appreciated! Thanks!

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cassP Contributor
cassP
Posted

My symptoms:

wake up nearly every morning with abdominal pain, bloating, gas, occasional nausea

-occurs later on in the day after eating as well

Tests:

Total IgA= Low

IgG= negative for celiac

I'm really frustrated and don't know what to do next. I just want someone to tell me exactly what's wrong and be 100% sure. I've considered trying to eat gluten free and see how I feel, I just would really like to know for sure before I change my whole lifestyle.

Any advice/suggestions would be greatly appreciated! Thanks!

so we know from your first result that you're Iga deficient

but what is the "IgG" ??? is it for Tissue Transglutamase? or Antigliadin?

it looks to me that your doctor didnt run enough tests. its not a complete picture.

you could have a number of different things- and our docs need to do a better job of finding the answers.

you may need to go on a proper gluten challenge for a more complete blood test and endoscopy. plus you may be interested in a colonoscopy to rule out anything else.

also- research on this forum, there's a lot of info to digest and understand.

nora-n Rookie
nora-n
Posted

Yes, WHAT IgG tests were done?

Celiac tests are :

Ttg IgA and IgG

deamidated gliadin IgA and IgG

antigliadin IgA and IgG

EMA, they look for IgA with an electron microscope and there is no IgG version of that one, but if they list it, it is most likely the ttg test

lost4o4 Newbie
lost4o4
Posted
  • Author

The igG test was: TTG AB igG

nora-n Rookie
nora-n
Posted

Yes, they definitely should have done the ttg IgA, since it is known that the ttg IgG alone picks up only a few of the celiacs.

And now more and more labs do the deamidated gliadin test, ask for all tests,

ttgIgA

deamidated gliadin IgA

antigliadin IgA

EMA

lost4o4 Newbie
lost4o4
Posted
  • Author

Thank you for your respsonse!

They did do these tests also:

Gliadin IgA AB and TTG AB IgA

and those were negative but that wasn't conclusive because my total immunoglobulin A was low. That's why they did TTG AB IgG.

Should I still request the EMA?

cassP Contributor
cassP
Posted

Thank you for your respsonse!

They did do these tests also:

Gliadin IgA AB and TTG AB IgA

and those were negative but that wasn't conclusive because my total immunoglobulin A was low. That's why they did TTG AB IgG.

Should I still request the EMA?

yes, the EMA was the only SOLID positive on my test.

BUT- again, you need to be eating enough gluten (4 slices of bread a day) 6 weeks to 2 or 3 months for an accurate test. there's also a newer test people here keep mentioning- i'll get the name wrong... sorry

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nora-n Rookie
nora-n
Posted

4 slices may be way too little.

You have to do the math. The latest recommendations are 0,5 grams gluten per kg per day.

I did the math, bought a bread to weigh it and do the math.

I weigh 54 kg and 0,5g/ kg works out to very very close to half a loaf a day.....8 slices.

cassP Contributor
cassP
Posted

4 slices may be way too little.

You have to do the math. The latest recommendations are 0,5 grams gluten per kg per day.

I did the math, bought a bread to weigh it and do the math.

I weigh 54 kg and 0,5g/ kg works out to very very close to half a loaf a day.....8 slices.

wow, no wonder my tests were so inconclusive. but i couldnt have done more than 4 slices/2 weeks-> my anxiety was THRU the roof!!

hazelbrown10 Rookie
hazelbrown10
Posted

wow, no wonder my tests were so inconclusive. but i couldnt have done more than 4 slices/2 weeks-> my anxiety was THRU the roof!!

Wow, that's a bummer! Seems like lots of non-celiac people would even feel sick from eating 8 slices of bread! Although if you break it up with a sandwich, bowl of cereal, some pasta and some gluten-snacks... maybe that would equal out to 8 slices. Hmm...

ravenwoodglass Mentor
ravenwoodglass
Posted

Wow, that's a bummer! Seems like lots of non-celiac people would even feel sick from eating 8 slices of bread! Although if you break it up with a sandwich, bowl of cereal, some pasta and some gluten-snacks... maybe that would equal out to 8 slices. Hmm...

Yea most people eat that and more in a day. 2 slices of toast with breakfast and a sandwich for lunch and you got 4 slices already. Add in your pasta or a bun with a burger, a doughnut, a piece of cake or pie for a snack or dessert well you got the idea. If someone isn't celiac they can eat all that and more without a reaction and many do on a daily basis.

nora-n Rookie
nora-n
Posted

Yes and the point is that one needs much damage for the tests to be positive, and for a challenge many people need a lot of gluten for the tests to be positive.

And, time matters too. The longer one is on the gluten challenge, the more patients turn positive.

Herer we can buy a home test at the pharmacy, so it might be possible to go on the gluten challenge and take the home test after six weeks and then continue on the gluten challenge if the test is still negative.

According to postings in Europe, the home test is often more sensitive than the hospital ttg test. But, if the home test is positive, one will probably have a positive endoscopy.

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