Help With Results

[Newgs]

Hello I have a question with reference to my youner son's results.

His HLA DQ2 (DQA1*05/DQB1*02) Positive

HLA DQ8 (DQA1*03/DQB1*302) Negative

HLA Variants detected

hla dqa1 05

hladqa1 -

hladqb1 0201

hladqb1 0301

Anti-endomysial <1:10

GLIADIN IGG ABS. 75

GLIADIN IgA, Abs 83

So the PA comes to me and tells me and hands me a note celiac + but dna does not suggest gluten sensitivity. I am not sure what she means by that. Can someone please explain. I had the same positive hla result and she told me I was gluten sensitivie, I had lesser gliadin results, I came up weak positive. The results above show a strong positive, am I right.

Any help offered would be greatly appreciated. Waiting on the DNA results of my older son, which I will get next week.

His gliadin came up

Anti endomysial <1:10

GLIADIN IGG ABS. 38

GLIADIN IgA, Abs. <20

Would it be safe to assume that he is also producing antibodies to gluten due to the elevated GLIADIN IGG

Thank you

[Emilushka]

What are the reference ranges?

[cassP]

ok, it is hard to read without ranges, and im not very good reading genes unless they're translated into "subtypes".

but anyways, my best guess- is that your younger son has a DQ 2.5 ? this is a "classic" Celiac gene. and maybe the nurse just had a bad way of communicating- that your younger son had a Celiac gene but not the genes that ONLY suggest gluten sensitivity.

for example- DQ2 & DQ8 are considered Celiac genes, and the other DQ genes are considered Gluten sensitive. that's the language for now, altho im sure that will change.

also- i THINK your younger son is positive on the Antigliadin iga & igg.

i ThINK your older son is positive on the Antigliadin Igg but negative on the iga. yes- a positive Igg is still a positive. perhaps your older son is iga deficient which would explain why his iga was negative, but the igg positive.

again- i am guessing, because there are no reference ranges. im just comparing it to my lab... but every lab is different.

[Takala]

Can you put the full text of the lab test up there, made up example like this

test for such and such. results= >10, (greater than 10 measuring units ). Reference range is 1 to 30. (0 to 9 is no, 10 to 20 is yes weak to medium positive, 21 to 30 is high)

On the numbers for the genes, I'm pretty sure you've dropped one digit. No, wait, I'm pretty sure they dropped one digit. whatever.

HLA - DQ2 is "positive"

DQB1*0201 and DQA1*0501

The *0201 and the *0501 combined are "most frequently found in celiac disease."

Kid is positive for at least one copy of the celiac DQ2 gene.

_________

Genes. They are finding and refining the gene classifications for celiac and gluten sensitivity all the time. The end result is the same, if there are symptoms, signs of antibodies and auto immune responses, and some sort of genes for either: going on a gluten free diet to relieve the symptoms and stop the auto immune reaction to the proteins in wheat, rye, and barley.

Celiac genes: HLA DQ2 and HLA DQ8. Most celiacs have one or the other. There can be one or two copies, depending on whether it came from mom, dad, or both mom and dad. People who inherit two DQ2s get twice the fun, er, a greater risk of developing celiac.

Not everybody who inherits the genes gets the disease, most people who are carriers don't, but they have the ability to be triggered. Populations of carriers vary by ethnic group and where their ancestors originated from on the globe.

Other celiac genes might be DQ 7.5 and DQ 1

DQ 7.5 = DQA1*0505: DQB1*0301

see also Open Original Shared Link

Gluten intolerant genes: Other genes which may be associated with the symptoms of gluten intolerance, but which aren't the "official" celiac genes.

______

Just to be totally confusing, all celiacs are sensitive to gluten, the proteins found in wheat, rye, and barley. "Gluten intolerance" may also be the phrase used to describe people who have definite reactions to gluten, and who respond to a gluten free diet, and have symptoms of auto immune disease, but other wise flunk the blood tests. They also may have symptoms that are different than the classic wasting away and acute D and gut problems, such as ataxia and neurological problems, thyroid, arthritis, bone loss, kidney and liver problems, etc. Medical researchers now realizing this is really a set of people with a disease.

If you are the same DNA on tests, and a weak positive, you're likely at least celiac, just not full blown yet. If the kid has that DNA and they called him "celiac" and his numbers are bigger than yours, same labs, .... welcome to the club.

But some of us...

As an example, I will always now be "gluten intolerant." I react to gluten in many ways. But never celiac by official blood tests looking for antibodies. Haven't been in a big hurry to genetically test, don't have any qualms about diet, I probably fall into the less common categories if I had to guess. I have lots of ancestries very likely to be carriers, had relatives with the same symptoms, all of whom smoked like chimneys (smoking is said to retard celiac symptoms) I'm very light complexioned. Duh !