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Trying To Understand How To Read These Results

melikamaui

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melikamaui Explorer
melikamaui
Posted

Can anyone help me figure out this genetic panel? These are my son's results. I know he has a very high chance of having celiac disease, and his doctor believes that he does in fact have it, she diagnosed him already. I'd just like to know what each of these things stand for.

Thanks for any help.

002.5 (HLA OOA1*05:00B1"(201) and other non-risk alleles.

Category 4, DQ2 heterozygous, Increased Risk 10X, Relative Risk HIGH

Category 8, DQ2 Homozygous, Increased Risk 31X, Relative Risk EXTREMELY HIGH

Category 7, DQ2/other high risk gene, Increased Risk 16X, Relative Risk VERY HIGH

Category 6, DQ2/DQ8, Increased Risk 14X, Relative Risk VERY HIGH

Category 5, DQ8 Homozygous, Increased Risk 10X, Relative Risk HIGH

Category 4, DQ2 heterozygous, Increased Risk 10X, Relative Risk HIGH

Category 3, DQ8 heterozygous, Increased Risk 2X, Relative Risk MODERATE

Category 2, DQ2/other low risk gene, Increased Risk <1X, Relative Risk LOW

Category 1, DQx, DQ8, Increased Risk <o.1, Relative Risk EXTREMELY LOW

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melikamaui Explorer
melikamaui
Posted
  • Author

Anyone? Bueller?...

Mama Melissa Enthusiast
Mama Melissa
Posted

What category does he fall in? I only see his other risk alleles

melikamaui Explorer
melikamaui
Posted
  • Author

What category does he fall in? I only see his other risk alleles

DQ2 heterozygous, Increased Risk 10X, Relative Risk HIGH

What do/does the other risk alleles mean? I don't understand that part at all.

Thanks for any help!

Melika

Skylark Collaborator
Skylark
Posted

He has one risk allele, DQ2.5, and one non-risk allele which hasn't been specified. That gives him 10x risk for celiac with respect to the general US population.

I'm not sure what else you're asking. What do you mean by "each of these things"? Is this article helpful?

Open Original Shared Link

melikamaui Explorer
melikamaui
Posted
  • Author

That's very helpful, thanks!

nora-n Rookie
nora-n
Posted

I do not understand the difference between category 1 and 3 in this list

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    • StuartJ
      Gluten Sensitivity

      By StuartJ · Posted

      Well, three months later and a startling revelation!  After going gluten free (and nearly bankrupt buying special foods), my wife made a lunch of meat potatoes and gravy made with Bertolli white sauce - no wheat there right?  Big flare up withing hours and I was really wiped out with it.  She rechecks the label on the sauce bottle and right at the bottom of the ingredients XANTHAN GUM. There's our #1 suspect again!  So by way of experimenting, she decided to try making a loaf of bread with just regular white flour like she used to do and see what happened; the familiar smell hit me when I walked in the door last night and I sat down to eat this still warm, fresh goodness - I thought even if I have to take Imodium sandwiches, it will be worth it 😋 No ill effects, either overnight or today!  Half the loaf is now gone because I had some for supper, saving just one last slice for breakfast in the morning` - I've used the bathroom once and that was normal, so maybe it is not the gluten after all? Can't wait to try a beer! 😁
    • trents
      Could this be a new intolerance

      By trents · Posted

      Unfortunately, the development of celiac disease usually is not an end in and of itself. It usually brings along friends, given time. It is at heart an immune system dysfunction which often embraces other immune system dysfunctions as time goes on.
    • Celiacpartner
      Could this be a new intolerance

      By Celiacpartner · Posted

      Thanks so much for the responses. I will urge him to go for further investigation. To be 48yrs old and develop a new allergy.. ugh, As if celiac disease isn’t enough! 
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      By trents · Posted

      This does not seem to be an anaphylactic response but I agree it would be wise to seek allergy-food sensitivity testing. You might look into ALCAT food sensitivity testing.
    • Rogol72
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