Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

My Mom Has Both Celiac Hladq Genes

alicewa

Recommended Posts

alicewa Contributor
alicewa
Posted

My mom has both celiac hladq genes (hla-dq 2,8). Does this mean that I'd definitely have at least 1, both or none?

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


psawyer Proficient
psawyer
Posted

If I understand things correctly, you inherit 50% of your genes from each parent. So you have a fifty-fifty chance of having each one. Of the four equally likely situations, one has neither, one has both, and two have one but not the other. This assumes that your mother has only one copy of each gene. If she has two, then it would be impossible for her not to pass at least one on.

If I'm wrong on this, I'm sure one of our more knowledgeable genetics people will correct me.

Jestgar Rising Star
Jestgar
Posted

Yep, it's that old Punnet square from high school biology

You got either 2 or 8 from Mom, and one of whatever Dad has.

saintmaybe Collaborator
saintmaybe
Posted

Yep, your Mom is what's called a super-celiac. She's a heterodimer for the two most commonly associated celiac alleles. You have either 2 or 8 and whatever you got from your Dad. It may be worth testing in yourself, because celiac genes are at a high rate of prevalence in the general population as well. Meaning, there's nothing that says you couldn't have inherited ANOTHER celiac gene from your Dad if he's a latent celiac. One copy on its own, which you know you have however, would be enough to *recommend* a gluten free diet.

alicewa Contributor
alicewa
Posted
  • Author

Yep, your Mom is what's called a super-celiac. She's a heterodimer for the two most commonly associated celiac alleles. You have either 2 or 8 and whatever you got from your Dad. It may be worth testing in yourself, because celiac genes are at a high rate of prevalence in the general population as well. Meaning, there's nothing that says you couldn't have inherited ANOTHER celiac gene from your Dad if he's a latent celiac. One copy on its own, which you know you have however, would be enough to *recommend* a gluten free diet.

My mom doesn't seem to have celiac disease yet (unlike me). She's been feeling well and healthy to date. Is it likely (i.e. what are the chances) that she might become celiac?

Also is DQ2.5 different to DQ2?

saintmaybe Collaborator
saintmaybe
Posted

My mom doesn't seem to have celiac disease yet (unlike me). She's been feeling well and healthy to date. Is it likely (i.e. what are the chances) that she might become celiac?

From what I've read, the highest associated risk understood AT THIS TIME in western medicine is with two copies of DQ2. In genetic parlance, this would make you homozygous for DQ2. Homozygotes for DQ2 who continue to eat wheat have a 30-40% chance of developing celiac disease over the course of their entire life.

DQ8 is the second most common allele associated with celiac. I can't find hard numbers associated with rate of disease onset, but know that it is associated with both celiac and type 1 diabetes. There are also risks associated with DQ8 and the development of rheumatoid arthritis. Again, none of this means that your mom WILL develop these diseases, just that it's *possible.*

I would highly encourage both of you to enjoy the benefits of a gluten free lifestyle, if possible.

alicewa Contributor
alicewa
Posted
  • Author

Thanks for your replies. Just another question: Is it only possible for you to have two HLA-DQ genes?

(i.e. my mom has hla-dq2 and hla-dq8 does that mean she won't have any other hla-dq gene? (e.g. hla-dq3, hla-dq4, etc.)

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


MsCurious Enthusiast
MsCurious
Posted

Thanks for your replies. Just another question: Is it only possible for you to have two HLA-DQ genes?

(i.e. my mom has hla-dq2 and hla-dq8 does that mean she won't have any other hla-dq gene? (e.g. hla-dq3, hla-dq4, etc.)

These links will help explain things to you. You only have two... one from mom ... one from dad.

You inherited either HLA-DQ2 or HLA-DQ8 from your mom, and you inherited one gene from your dad (he has two but you got only one of his).

So essentially, you have one gene for sure that can predispose you to getting celiac disease... however that does not mean that you WILL get celiac disease... just that the possibility exists.

And if you have HLA-DQ2.5 rather than HLA-DQ2.2 you're in the pool of possibility ... but according to this recent study (below link)HLA-DQ2.2 is not a factor in celiac disease, unless it is accompanied by HLA-DQ2.5 (but not vice versa).

Now that you're sufficiently confused, here are the links. :)

(PS: DQ2.2 and DQ2.5 are both referred to in general terms as DQ2, however they have a significant difference that causes DQ2.5 to be directly related to celiac disease, whereas DQ2.2 is not unless it is accompanied by DQ2.5) Its all explained in the link. ;)

Open Original Shared Link

Open Original Shared Link

Good luck to you! Hope you find the answers you seek.

alicewa Contributor
alicewa
Posted
  • Author

Thanks for this. I'll have to give it more of a look into. My mom now plans to go gluten free to protect herself. What do you think about this idea?

Also is it more likely that I got the hla-dq2 or hla-dq8 ? I'm curious about the odds you'd come up with. :rolleyes:

saintmaybe Collaborator
saintmaybe
Posted

Thanks for this. I'll have to give it more of a look into. My mom now plans to go gluten free to protect herself. What do you think about this idea?

Also is it more likely that I got the hla-dq2 or hla-dq8 ? I'm curious about the odds you'd come up with. :rolleyes:

According to the rules of random genetic assortment, you are equally likely to have DQ2 or DQ8. That is a 50/50 chance. Of course, there have been published accounts of nonrandom genetic assortment, but I'm not sure where the field is at in terms of celiac studies. For our sake, you should assume 50/50.

nora-n Rookie
nora-n
Posted

A large proportion of the general population has DQ2 and some less have DQ8, and only about 2-3% of the general population have ttg antibodies, so having these genes does not mean too much....

HLA DQ is about the risk of having celiac. The greatest risk is having a sibling with celiac and sharing the same DQ genes, tehn the risk is 40%.

Also, DQ genes are only responsible for celiac risk with 40%.

They have found 9 other genes that contribute to the risk for developing celiac.

Your mother might get better from things she did not know she had, after going gluten free.....

GlutenFreeManna Rising Star
GlutenFreeManna
Posted

The statistics say that immediate relatives of those with celiac (parents, children, or siblings) have a 1 in 22 chance of have celiac themselves. I don't know how this translates now that you know her genes but since you are diagnosed celiac your mom has AT LEAST a 1 in 22 chance of having it herself. She should get herself tested (for the antibodies) before going gluten-free, even if she has no noticeable symptoms.

Open Original Shared Link

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. Jsingh
      - Jsingh replied to lizzie42's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      1

      Son's legs shaking

      Hi, My 7 year daughter has complained of this in the past, which I thought were part of her glutening symptom, but more recently I have come to figure out it's part of her histamine overload symptom. This one symptom was part of her broader profile, which included irritability, extreme hunger, confusion, post-nasal drip. You might want to look up "histamine...
    2. lizzie42
      - lizzie42 posted a topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      1

      Son's legs shaking

      My 5yo was diagnosed with celiac last year by being tested after his sister was diagnosed. We are very strict on the gluten-free diet, but unsure what his reactions are as he was diagnosed without many symptoms other than low ferritin. He had a school party where his teacher made gluten-free gingerbread men. I almost said no because she made it in her...
    3. trents
      - trents replied to Paulaannefthimiou's topic in Gluten-Free Foods, Products, Shopping & Medications
      1

      Bob red mill gluten free oats

      Not necessarily. The "Gluten Free" label means not more than 20ppm of gluten in the product which is often not enough for super sensitive celiacs. You would need to be looking for "Certified Gluten Free" (GFCO endorsed) which means no more than 10ppm of gluten. Having said that, "Gluten Free" doesn't mean that there will necessarily be more gluten than "Certified...
    4. trents
      - trents replied to jenniber's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      10

      Disaccharide deficient, confusing biopsy results, no blood test

      I think it is wise to seek a second opinion from a GI doc and to go on a gluten free diet in the meantime. The GI doc may look at all the evidence, including the biopsy report, and conclude you don't need anything else to reach a dx of celiac disease and so, there would be no need for a gluten challenge. But if the GI doc does want to do more testing, you...
    5. Paulaannefthimiou
      - Paulaannefthimiou posted a topic in Gluten-Free Foods, Products, Shopping & Medications
      1

      Bob red mill gluten free oats

      Are Bobresmill gluten free oats ok for sensitive celiacs?
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      132,859
    • Most Online (within 30 mins)
      7,748
    Santa Don
    Newest Member
    Santa Don
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Who's Online (See full list)

  • Upcoming Events

  • Posts

    • Jsingh
      Son's legs shaking

      By Jsingh · Posted

      Hi,  My 7 year daughter has complained of this in the past, which I thought were part of her glutening symptom, but more recently I have come to figure out it's part of her histamine overload symptom. This one symptom was part of her broader profile, which included irritability, extreme hunger, confusion, post-nasal drip. You might want to look up "histamine intolerance". I wish I had known of this at the time of her diagnosis, life would have been much easier.  I hope you are able to figure out. 
    • lizzie42
      Son's legs shaking

      By lizzie42 · Posted

      My 5yo was diagnosed with celiac last year by being tested after his sister was diagnosed. We are very strict on the gluten-free diet, but unsure what his reactions are as he was diagnosed without many symptoms other than low ferritin.  He had a school party where his teacher made gluten-free gingerbread men. I almost said no because she made it in her kitchen but I thought it would be ok.  Next day and for a few after his behavior is awful. Hitting, rude, disrespectful. Mainly he kept saying his legs were shaking. Is this a gluten exposure symptom that anyone else gets? Also the bad behavior? 
    • trents
      Bob red mill gluten free oats

      By trents · Posted

      Not necessarily. The "Gluten Free" label means not more than 20ppm of gluten in the product which is often not enough for super sensitive celiacs. You would need to be looking for "Certified Gluten Free" (GFCO endorsed) which means no more than 10ppm of gluten. Having said that, "Gluten Free" doesn't mean that there will necessarily be more gluten than "Certified Gluten" in any given batch run. It just means there could be. 
    • trents
      Disaccharide deficient, confusing biopsy results, no blood test

      By trents · Posted

      I think it is wise to seek a second opinion from a GI doc and to go on a gluten free diet in the meantime. The GI doc may look at all the evidence, including the biopsy report, and conclude you don't need anything else to reach a dx of celiac disease and so, there would be no need for a gluten challenge. But if the GI doc does want to do more testing, you can worry about the gluten challenge at that time. But between now and the time of the appointment, if your symptoms improve on a gluten free diet, that is more evidence. Just keep in mind that if a gluten challenge is called for, the bare minimum challenge length is two weeks of the daily consumption of at least 10g of gluten, which is about the amount found in 4-6 slices of wheat bread. But, I would count on giving it four weeks to be sure.
    • Paulaannefthimiou
      Bob red mill gluten free oats

      By Paulaannefthimiou · Posted

      Are Bobresmill gluten free oats ok for sensitive celiacs?
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.