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Interpretation Of Blood Work Results

Debbie48

By Debbie48
in Coping with Celiac Disease

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Debbie48 Rookie
Debbie48
Posted

Can anyone explain/interpret the following blood work results?

Immunoglobulin A-serum: in normal range

Gliadin Antibody, IGA: abnormally high

Gliadin, IGG: in normal range

Tissue Transglutaminase-A: in normal range

Any help would be much appreciated!

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ravenwoodglass Mentor
ravenwoodglass
Posted

That is a positive celiac panel. Don't go gluten free yet though if you are having an endo. Wait until the endo is done and then you can go gluten free that day. Even if the endo should come back negative you still need to be on the diet. Ask any other questions you need to and read as much as you can here. I hope you are feeling better soon.

Debbie48 Rookie
Debbie48
Posted
  • Author

That is a positive celiac panel. Don't go gluten free yet though if you are having an endo. Wait until the endo is done and then you can go gluten free that day. Even if the endo should come back negative you still need to be on the diet. Ask any other questions you need to and read as much as you can here. I hope you are feeling better soon.

Is it uncommon to have a positive Gliadin Antibody, IGA and negative for all other blood work and a biopsy that shows no damage?

Also, does the number mean anything at all? For example, a 24 versus a 36 when the normal Gliadin Antibody, IGA is 0-15?

ravenwoodglass Mentor
ravenwoodglass
Posted

Is it uncommon to have a positive Gliadin Antibody, IGA and negative for all other blood work and a biopsy that shows no damage?

Also, does the number mean anything at all? For example, a 24 versus a 36 when the normal Gliadin Antibody, IGA is 0-15?

No that is not uncommon at all. Celiac tests do have a high rate of false negatives but not false positives.

Skylark Collaborator
Skylark
Posted

Is it uncommon to have a positive Gliadin Antibody, IGA and negative for all other blood work and a biopsy that shows no damage?

It happens. This is why anti-gliadin alone is not considered a good test for celiac disease. The biopsy can also come back fully celiac, or somewhere in-between. You really need a biopsy with your results so keep eating gluten.

Thing is, developing celiac is a process and the anti-gliadin can be the herald of gluten-caused inflammation and developing autoimmunity. What the doctors don't realize is that most folks with anti-gliadin feel dramatically better off gluten whether or not they have the autoimmunity and a positive biopsy because gluten is causing a huge inflammation reaction. Chances are good that whatever landed you in the doctor's office will go away on a strict gluten-free diet.

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