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Need Help With Hla-Dq Testing

Nay44

By Nay44
in Doctors

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Nay44 Newbie
Nay44
Posted

I was just diagnosed with Celiac from blood work of >than 100 on TTg, 58.1 on IgG and 78.8 on IgA. Also had HLA-DQ typing done and these were the results which I need help with interpretation.

DQ alpha 1: 05:01,05

DQ beta 1: 02:01,03

Celiac gene pairs present: Yes

What are the genes that I have? Did they check for DQ2 and DQ8. I know you have two copies of the DQ gene so trying to figure out what mine are from the above findings. The tests were performed at Mayo Clinic in Rochester, MN.

I do not have any major gastro systems and don't feel sick after eating gluten. I was complaining of fatigue and feeling bloated so doctor ran celiac panel. Couldn't believe it. Had scope done last week but no results yet. Doctor said he saw scalloping of the 2nd and 3rd duodenum??? Have been gluten free for 5 days....

Please help. Had all 3 kids tested and all were negative from the Celiac panel tests. I would think one of them would have it if I have it.

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mushroom Proficient
mushroom
Posted

Sorry, I am not a genetic expert -- but others here will help you with that.

The scalloping is a sign of celiac - I believe you will get a positive biopsy report. Some of your kids may well have a celiac gene if you do; if so, it doesn't mean that they will automatically develop the disease - it just shows that they have the propensity to do so. There is generally a trigger which sets it off - physical or emotional stress, for example. The genes are not that uncommon and I believe the majority of the people who carry them do not seem to get celiac disease. You should watch them for symptoms though.

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      By Scott Adams · Posted

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      Since you compromised the validity of the antibody testing by experimenting with gluten withdrawal ahead of the testing, you are faced with two options: 1. Reintroduce significant amounts of gluten into your diet for a period of weeks, i.e., undertake a "gluten challenge". The most recent guidelines are the daily consumption of at least 10g of gluten (about the amount found in 4-6 slices of wheat-based bread) for at least two weeks leading up to the day of testing. Note: I would certainly give it more than two weeks to be sure. 2. Be willing to live with the ambiguity of not knowing whether gluten causes you problems because you have celiac disease or NCGS (Non Celiac Gluten Sensitivity). There is no test for NCGS. Celiac disease must first be ruled out and we have tests for it. Celiac disease has an autoimmune base. NCGS does not. GI symptoms overlap. In the early stages of celiac disease, other body systems may not be showing stress or damage so, symptomatically, it would be difficult to distinguish between celiac disease and NCGS. Both conditions require elimination of gluten from the diet for symptom relief. Some experts feel that NCGS can be a precursor to celiac disease.
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      I had been eating reduced gluten until about 3 days before the test. I did realize that wasn’t ideal, but it was experimental to see if gluten was actually bothering me. One slip up with soy sauce and it was quite clear to me that it was, lol. 
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