Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Help With Test Results?

abby03

Recommended Posts

abby03 Contributor
abby03
Posted

Back in January I got the blood test done for Celiac but wasn't able to get copies of my results until yesterday. Shortly after my blood test, I had an endoscopy. The endoscopy initially showed damage that apparently looked like Celiac but the the biopsy came back negative. About two months ago my GI doctor went ahead and put me on a gluten free diet and said that I had a positive blood test (I was told differently by my regular doctor, who was the one that ordered the tests.), all the symptoms, and that the endoscopy looked like Celiac even though the biopsy was negative. She basically told me that I had Celiac and to try the diet. So for the past 2 months or so I've been gluten free and feel somewhat better but not completely. I went to a nutritionist and she was confused because my primary doctor wrote "positive gluten intolerance" on my record while my GI apparently had Celiac written down. That left me confused so I got the results for myself and am hoping that someone on here can tell me what they mean and if I even need to be on a gluten free diet. Here they are:

Deamidated Gliadin Abs, IgA: Result: 14 Normal Range: 0-19 Normal

Deamidated Gliadin Abs, IgG: Result: 27(Abn: H) Normal Range: 0-19 Weak Positive

t- Transglutaminase(tTG) IgA: Result: 2 Normal Range: 0-3 Negative

t- Transglutaminase(tTG) IgG: Result: 4 Normal Range: 0-5 Negative

Endomysial Antibody IgA: Result: Negative

Immunoglobulin A, Qn, Serum Result: 177 Normal Range: 61-348 Negative

From what I can see, I only have one weak positive out of the whole panel. And from what I read, that's one of the least accurate tests. And I have a negative biopsy. Do I even need to be eating gluten free with these results? Do I have Celiac disease or not? Thanks for any help you can give me!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Hornet Rookie
Hornet
Posted

I am not an MD and I believe you need to get your medical ppl together or see a different GI doc for a second opinion. I can't speak for others who will reply, but I would not change anything until you meet with your doc and discuss what is better, what isn't and get these questions resolved. Good luck.

abby03 Contributor
abby03
Posted
  • Author

Thanks for replying. :)

I don't think switching doctor's will be necessary. I like my GI doctor and I'm sort of stuck with my regular doctor anyway. I've already had all the tests done and gotten results. Now I just need someone to interpret them and help me figure out if I have Celiac or not. I know that some people on here are good at interpreting test results and knowing what each test means so hopefully someone can give me an answer!

MitziG Enthusiast
MitziG
Posted

Actually, the DGP is a very specific and reliable test. It is not uncommon to have the majority of bloodwork come back negative. Antibodies are mostly in the gut, not the bloodstream.

My guess would be that you are in early stages of the disease. Celiac is patchy, and easy to miss on a biopsy. The fact that your GI saw visible damage is a big clue though. Had the disease progressed, eventually your bloodstream would become mmore saturated with antibodies.

Healing takes time. The fact that you have noticed some improvement is also telling. Many people take 6 months or more beefore they see significant improvement.

So, in answer to your question- yes, you have celiac, and yes, you do need to be on the gluten free diet for life.

abby03 Contributor
abby03
Posted
  • Author

Actually, the DGP is a very specific and reliable test. It is not uncommon to have the majority of bloodwork come back negative. Antibodies are mostly in the gut, not the bloodstream.

My guess would be that you are in early stages of the disease. Celiac is patchy, and easy to miss on a biopsy. The fact that your GI saw visible damage is a big clue though. Had the disease progressed, eventually your bloodstream would become mmore saturated with antibodies.

Healing takes time. The fact that you have noticed some improvement is also telling. Many people take 6 months or more beefore they see significant improvement.

So, in answer to your question- yes, you have celiac, and yes, you do need to be on the gluten free diet for life.

Thanks for the help! I must have gotten the DGP confused with another test.. is it this one that has 99% accuracy? I read that one has 85% accuracy and I thought that was the one I tested positive in.

And just to be sure, false negatives on blood tests are extremely rare, correct? It probably sounds like I'm trying to deny that I have celiac or something and I'm not- I just want to be 100% sure that I have it. I've done pretty well with the diet for the past two months and have been lucky to only have a few rough days. I've actually enjoyed eating healthier and learning new recipes and such! Anyway, thanks again for the help! :)

beachbirdie Contributor
beachbirdie
Posted

From what I can see, I only have one weak positive out of the whole panel. And from what I read, that's one of the least accurate tests. And I have a negative biopsy. Do I even need to be eating gluten free with these results? Do I have Celiac disease or not? Thanks for any help you can give me!

The Deamidated Gliadin is actually pretty accurate. There is an older version of the test for gliadin antibodies, that is the one that's not so specific.

I think a positive DGP means celiac.

Also...the term "positive gluten intolerance" is sometimes used interchangeably with "celiac". Though you apparently didn't have the villous atrophy, you do most likely have celiac. You just haven't been badly damaged yet. Either that, or they didn't do enough biopsy samples...that happens a lot.

Do you have a copy of the biopsy report? Reading for yourself can tell you a lot more than just hearing "negative" from the doc.

Yes, you are reacting to gluten and need to be gluten-free.

Oh brother, I can see there were a lot of us here all at once, LOL. Sorry for the extraneous info! :ph34r:

abby03 Contributor
abby03
Posted
  • Author

The Deamidated Gliadin is actually pretty accurate. There is an older version of the test for gliadin antibodies, that is the one that's not so specific.

I think a positive DGP means celiac.

Also...the term "positive gluten intolerance" is sometimes used interchangeably with "celiac". Though you apparently didn't have the villous atrophy, you do most likely have celiac. You just haven't been badly damaged yet. Either that, or they didn't do enough biopsy samples...that happens a lot.

Do you have a copy of the biopsy report? Reading for yourself can tell you a lot more than just hearing "negative" from the doc.

Yes, you are reacting to gluten and need to be gluten-free.

Oh brother, I can see there were a lot of us here all at once, LOL. Sorry for the extraneous info! :ph34r:

I actually just read my first post and realized I made a typo. The "positive gluten intolerance" should be "possible gluten intolerance." My bad.

Also, I do not have a copy of the biopsy report. All I have is the paper they gave my parents at the hospital when I was still drugged up haha. That's the paper with pictures and the one that says they saw damage and suspected Celiac.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


nora-n Rookie
nora-n
Posted

yes, the DGP IgG is the most specific test around, after the EMA test.

GFinDC Veteran
GFinDC
Posted

HI Abby,

RE: your question about false negatives, yes, there are false negatives. False positives are rare but false negatives are not. The antibodies to your gut (celiac antibodies) are mostly in your gut where they do their work. They aren't aimlessly floating around the blood stream, they have a job to do and they go do it. Actually most of them are created in the gut to begin with. Your gut is a front line defense mechanism in protecting you from invading microbes, and it has lots of immune cells to fight that battle. If it didn't we would be in bad shape with eating all those little ugly buglies in our food each day. The stomach has hydrochloric acid to stop some of them but it isn't enough to kill all of them. That's why probiotics work.

Here is some reading material for new people and older people too.

Open Original Shared Link

FAQ Celiac com

http://www.celiac.co...celiac-disease/

Newbie Info 101

http://www.celiac.co...ewbie-info-101/

What's For Breakfast Today?

http://www.celiac.co...reakfast-today/

What Did You Have For Lunch Today?

http://www.celiac.co...or-lunch-today/

What Are You Cooking Tonight?

http://www.celiac.co...ooking-tonight/

http://www.celiac.co...399#entry802399

How bad is cheating?

http://www.celiac.co...t-periodically/

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,017
    • Most Online (within 30 mins)
      7,748
    Sjcucinotta
    Newest Member
    Sjcucinotta
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • sleuth
      Nicotine Gum For Gluten Symptoms.. Am I Crazy?

      By sleuth · Posted

      He is not just a psychiatrist.  He is also a neuroscientist.  And yes, I have already read those studies.   I agree with benfotiamine.  This is short term while glutened/inflammation occurs.  As I had already mentioned, these symptoms no longer exist when this phase passes.  And yes, I know that celiac is a disease of malnutrition.  We are working with a naturopath.
    • knitty kitty
      Nicotine Gum For Gluten Symptoms.. Am I Crazy?

      By knitty kitty · Posted

      Please do more research before you settle on nicotine. Dr. Paul New house is a psychiatrist.  His latest study involves the effect of nicotine patches on Late Life Depression which has reached no long term conclusions about the benefits.   Effects of open-label transdermal nicotine antidepressant augmentation on affective symptoms and executive function in late-life depression https://pubmed.ncbi.nlm.nih.gov/39009312/   I'm approaching the subject from the Microbiologist's point of view which shows nicotine blocks Thiamine B1 uptake and usage:   Chronic Nicotine Exposure In Vivo and In Vitro Inhibits Vitamin B1 (Thiamin) Uptake by Pancreatic Acinar Cells https://pubmed.ncbi.nlm.nih.gov/26633299/   While supplementation with thiamine in the form Benfotiamine can protect from damage done by  nicotine: Benfotiamine attenuates nicotine and uric acid-induced vascular endothelial dysfunction in the rat https://pubmed.ncbi.nlm.nih.gov/18951979/   I suggest you study the beneficial effects of Thiamine (Benfotiamine and TTFD) on the body and mental health done by Dr. Derrick Lonsdale and Dr. Chandler Marrs.  Dr. Lonsdale had studied thiamine over fifty years.   Hiding in Plain Sight: Modern Thiamine Deficiency https://pmc.ncbi.nlm.nih.gov/articles/PMC8533683/ I suggest you read their book Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition.     Celiac Disease is a disease of malabsorption causing malnutrition.  Thiamine and benfotiamine: Focus on their therapeutic potential https://pmc.ncbi.nlm.nih.gov/articles/PMC10682628/
    • sleuth
      Nicotine Gum For Gluten Symptoms.. Am I Crazy?

      By sleuth · Posted

      Thanks for your response.  Everything you mentioned he is and has been doing.  Tobacco is not the same as nicotine.  Nicotine, in the form of a patch, does not cause gastrointestinal irritation.  Smoking does. He is not smoking.  Please do your research before stating false information. Dr. Paul Newhouse has been doing research on nicotine the last 40 years at Vanderbilt University Medical Center.  
    • Jmartes71
      Fighting for a name

      By Jmartes71 · Posted

      Im so frustrated and still getting the run around trying to reprove my celiac disease which my past primary ignored for 25 years.I understand that theres a ray of medical that doctors are limited too but not listening and telling the patient ( me) that im not as sensitive as I think and NOT celiac!Correction Mr white coat its not what I think but for cause and affect and past test that are not sticking in my medical records.I get sick violently with foods consumed, not eating the foods will show Im fabulous. After many blood draws and going through doctors I have the HLA- DQ2 positive which I read in a study that Iran conducted that the severity in celiac is in that gene.Im glutenfree and dealing with related issues which core issue of celiac isn't addressed. My skin, right eye, left leg diagestive issues affected. I have high blood pressure because im in pain.Im waisting my time on trying to reprove that Im celiac which is not a disease I want, but unfortunately have.It  has taken over my life personally and professionally. How do I stop getting medically gaslight and get the help needed to bounce back if I ever do bounce back to normal? I thought I was in good care with " celiac specialist " but in her eyes Im good.Im NOT.Sibo positive, IBS, Chronic Fatigue just to name a few and its all related to what I like to call a ghost disease ( celiac) since doctors don't seem to take it seriously. 
    • trents
      Celiac getting dentures

      By trents · Posted

      @Martha Mitchell, your reaction to the lens implant with gluten sounds like it could be an allergic reaction rather than a celiac reaction. It is possible for a celiac to be also allergic to gluten as it is a protein component in wheat, barley and rye.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.