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Russ H

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Everything posted by Russ H

  1. Russ H
    According to this study, IgG anti-DGP antibodies can show up before tTG antibodies in children with coeliac disease, which is basically what the results you posted show. https://www.naspghan.org/files/documents/pdfs/cme/jpgn/Antibodies_to_Deamidated_Gliadin_Peptide_in.13.pdf IgG anti-DGP are highly specific for coeliac and unlikely to be a false...
  2. Russ H
    Following discussion of B12 supplementation in another thread, this document by the European Scientific Committe on Food has comprehensive information regarding tolerable upper limits for various vitamins and minerals. It is a cornucopia of useful information. European Food Safety Authority - TOLERABLE UPPER INTAKE LEVELS FOR VITAMINS AND MINERALS Regarding...
  3. Russ H
    Yes, they are hereditary in people who wear shoes. They are not hereditary in people who don't wear shoes because they don't get them. Bunions are not caused by coeliac disease. Open Original Shared Link
  4. Russ H
    They have a hereditary component in the sense that foot width and shape is hereditary. Bunions are rare in people who habitually go barefoot. Women get bunions more often than men because they wear narrow shoes. It is largely a mechanical cause.
  5. Russ H
    Coeliac disease can lead to foot pain but I think it is unlikely to cause bunions. Bunions mainly arise due to an interplay of a foot shape and footwear. Most shoes are not anatomically foot shaped and push the big and little toes inwards. Beyond a certain point, the tendons running beneath the feet become displaced and pull the toes out of alignment. Eventually...
  6. Russ H
    It was just a guess. They sound like they are acting diligently.
  7. Russ H
    Good luck with that! The GP will follow NICE guidelines which are for tTG-IgA and total IgA. If tTG-IgA is borderline they will request an EMA test to follow up.
  8. Russ H
    Hello M4RK, That MCHC is only just outside the standard range and could just be a spurious result. It may be that there are some values which are within the standard range but suspicious, especially for a youngster. Out of curiosity, did they test serum ferritin and iron?
  9. Russ H
    Only bacteria and archaea have the necessary biological pathways to make B12. You can find it in some fermented foods and it is also found in some seaweeds due to a symbiotic relationship between the plant and bacterial colonies growing on it. I think these are very unreliable sources. Supplementary B12 is manufactured by industrial bacterial fermentation...
  10. Russ H
    This diagram of B12 absorption was posted on the BMJ Twitter feed. https://twitter.com/bmj_latest/status/1254724484747210752 In the natural diet, B12 is only found bound to animal protein. It is cleaved from the protein by the proteolytic action of pepsin. Pepsin itself is formed from pepsinogen in the presence of stomach acid - this is why proton...
  11. Russ H
    There are several ways that coeliac disease can lead to impaired B12 absorption. 1. Autoimmune pernicious anaemia is more common in people with other autoimmune conditions. In this case, either the parietal cells in the stomach that secrete intrinsic factor (IF) are destroyed, or antibodies to IF itself are made. 2. Impaired secretion of IF due...
  12. Russ H
    Hello SarahBee, It is possible to have slightly raised tTG antibodies with Crohn's disease and type 1 diabetes. However, The deamidated gliadin antibody tests are very specific for coeliac disease. It is quite possible to have negative endomysial antibodies in the blood serum with coeliac diease. I take it the haematologist referred you for the antibody...
  13. Russ H
    You could be IgA deficient, but it needs to be tested for. It is also possible to have coeliac disease and test negative for transglutaminase antibodies without being IgA deficient. It is a complex immunological condition. Certainly, your symptoms could be caused by coeliac disease. I had neurological symptoms and unusual skin complaints prior to diagnosis...
  14. Russ H
    Oh yes. Do you have any more information - symptoms, test results (total iGA for example)?
  15. Russ H
    Ah OK. Diabetes can give some of your symptoms, but your sugar levels don't indicate that.
  16. Russ H
    Is that 107-111 when fasting? If so, have you tried random testing or 2 hours post-prandial to see what it is like normally? Also, were you eating gluten in the 6 weeks prior to your coeliac testing?
  17. Russ H
    Hello Sarah and welcome to the forum. There are some very knowledgeable members who I am sure will comment soon. Indeed it is possible to have coeliac disease but negative serology. Incidentally, have you had your blood sugar tested?
  18. Russ H
    Liam, According to NICE guidelines, if you have persistent symptoms, you should be investigated for deficiencies by blood testing: https://cks.nice.org.uk/topics/coeliac-disease/management/management-of-confirmed-coeliac-disease/ I would show that to your GP and get checked out.
  19. Russ H
    The easiest way to naturally increase testosterone is weight training the large muscle groups. The problem with coeliac disease is not overall testosterone, which is often raised, but the conversion to the more active form DHT.
  20. Russ H
    I think it might be worth avoiding dairy products while the gut heals. I could not tolerate dairy while I was eating gluten but can now. Some people with coeliac develop lactose intolerance. Also, coeliac disease disrupts the intestinal barrier, allowing intestinal contents to permeate the gut wall. In this case, some people experience an immune reaction...
  21. Russ H
    I'll pass that on to a friend who has regular injections for pernicious anaemia. Coeliac disease is insidious, progressing with a gradually worsening constellation of non-specific symptoms and malaise so that the sufferer unknowingly becomes accustomed to being unwell. You have probably had it for many years, and as you recover will realise just how...
  22. Russ H
    Yes. Needs a large daily dose though (1000 ÎĽg) : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993789/
  23. Russ H
    Thanks, it seems to be improving. I have met a few people with the condition now, which has been a great help. Most of the work regarding this dates back to the 1980s. This is a frequently cited paper: https://pubmed.ncbi.nlm.nih.gov/6682819/ There are quite a few endocrine-related disorders related to coeliac disease such as type-1 diabetes...
  24. Russ H
    Hi I think you still have cause to be optimistic. Firstly, you know you have the condition and are treating it appropriately so that it goes into remission, and it won't get worse. You know this because your tTG2 antibodies have fallen to a low level. Secondly, you have only just got your antibodies down and healing takes time. If your gait issues...
  25. Russ H
    Although I believe I have had coeliac disease since childhood, my symptoms became much worse at the beginning of 2000 following influenza. I experienced significant weight loss, one of my friends describing me as 'emaciated' when she saw me after several years. One of the striking things is the amount of muscle I lost. Over the years I became quite feminized...
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