How Fast Do Antibodies Decline?

[durrsakja]

Thank you all for all the help and support so far. Does anyone know how quickly ttg and igA antibodies would decline on a strict gluten free diet?

[kareng]

This seems like what happened to me. My antibodies were beyond the highest positive. After 4 months, they were still very positive, but reduced greatly. More importantly, I felt much, much better.

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"What is the half-life of antibodies in the blood serum?

tTG and DGP typically decline to half their initial value in 3-4 months once on a gluten-free diet, but there are variations between patients."

[mushroom]

There is really no way of predicting this.  It can depend to some extent on how high the antibody levels were and how much damage has been done in the small intestine, and to a great extent on how strict you are with the diet and how sensitive you are to small amounts of gluten.  Doctors will often retest after three and six months, but I think three is much to soon.  For some unluckies their numbers barely budge in a year   but if you stick with it and refine your diet, there are really very few cases of people who do not eventually heal although some may not recover all the way as far as the damage is concerned.

[durrsakja]

Thank you. Any more stories on how quickly people saw their antibodies decline back to normal levels? Was that associated with the symptoms being resolved?