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Test Results Are In.....

Tasha2004

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Tasha2004 Contributor
Tasha2004
Posted

I guess the only positive test I still have is the Gliadin IgA. My doctor says it's not a big deal until the Ttg turns positive, but that it could be latent Celiac.

I'm still wondering if anyone has any advice on high IgA and what to do with the info. Mine was 74 normal is 25 or less.........

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lisa922 Apprentice
lisa922
Posted

Hi! I am in the process of trying to figure out my results also. My ttg was negative and my Iga was only 24, but I had some other numbers that were higher. My small intestine biopsy does show damaged villi. Today I spoke with a very knowledgable nurse at a gi office - she told me that if the ttg is positive, even with a normal Iga, Celiac should be investigated as a possibility. She did seem puzzled that my ttg was normal (or actually negative) and said that there is a genetic test that can be done I'm not sure how this is supposed to be written, but she said to ask for HLAeq2 and HLAdq8 tests. If they are both negative, then it is not Celiac. If one is positive and one is negative, you still have a 30% chance of not getting Celiac. I am going to post this info and see if anyone else is familiar with it and I'm going to request the test because I want to make sure I am following the right treatment. She said there are many other conditions that can damage your villi. Good luck with your results!

LISA

Tasha2004 Contributor
Tasha2004
Posted
  • Author

Thanks Lisa. I'm still doing research on this. I wish I could afford my own tests but I just cant right now.

You were brave enough for the biopsy, I havent chosen to do one yet.

Do you have symptoms?

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    • Scott Adams
      Test interpretations

      By Scott Adams · Posted

      Based on those results alone, it’s not possible to say you have celiac disease. The test that is usually most specific for celiac, tTG-IgA, is negative in your results, and the endomysial antibody (EMA) is also negative, which generally argues against active celiac disease. However, your deamidated gliadin IgA is elevated, and your total IgA level is also high, which can sometimes affect how the other antibody tests behave. Another important factor is that you were reducing gluten before the test, which can lower antibody levels and make the results less reliable. Because of that, many doctors recommend a gluten challenge (eating gluten regularly for several weeks) before repeating blood tests or considering an endoscopy if symptoms and labs raise concern. It would be best to review these results with a gastroenterologist, who can interpret them in context and decide whether further testing is needed.
    • trents
      Test interpretations

      By trents · Posted

      Since you compromised the validity of the antibody testing by experimenting with gluten withdrawal ahead of the testing, you are faced with two options: 1. Reintroduce significant amounts of gluten into your diet for a period of weeks, i.e., undertake a "gluten challenge". The most recent guidelines are the daily consumption of at least 10g of gluten (about the amount found in 4-6 slices of wheat-based bread) for at least two weeks leading up to the day of testing. Note: I would certainly give it more than two weeks to be sure. 2. Be willing to live with the ambiguity of not knowing whether gluten causes you problems because you have celiac disease or NCGS (Non Celiac Gluten Sensitivity). There is no test for NCGS. Celiac disease must first be ruled out and we have tests for it. Celiac disease has an autoimmune base. NCGS does not. GI symptoms overlap. In the early stages of celiac disease, other body systems may not be showing stress or damage so, symptomatically, it would be difficult to distinguish between celiac disease and NCGS. Both conditions require elimination of gluten from the diet for symptom relief. Some experts feel that NCGS can be a precursor to celiac disease.
    • suek54
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      By suek54 · Posted

      Hi Kayla Huge sympathies. I was diagnosed in December, after 8 months of the most awful rash, literally top to toe. Mine is a work in progress. Im on just 50mg dapsone at the moment but probably need an increased dose to properly put the lid on it. As you have been now glutened, I wondered whether it might be worth asking for a skin biopsy to finally get a proper diagnosis? Sue  
    • MicG
      Test interpretations

      By MicG · Posted

      I had been eating reduced gluten until about 3 days before the test. I did realize that wasn’t ideal, but it was experimental to see if gluten was actually bothering me. One slip up with soy sauce and it was quite clear to me that it was, lol. 
    • trents
      Test interpretations

      By trents · Posted

      Possibly. Your total IGA (Immunoglobulin A, Qn, Serum) is actually high so you are not IGA deficient. In the absence of IGA deficiency, the most reliable celiac antibody test would be the t-Transglutaminase (tTG) IgA for which your score is within normal range. There are other things besides celiac disease that might cause an elevated DGP-IGA (Deamidated Gliadin Abs, lgA) for which you do have a positive score. It might also be of concern that your total IGA is elevated as that can indicate some other health problems, some of which are serious.  Had you been practicing a gluten free or a reduced gluten free diet prior to the blood draw? Talk to your physician about these things. I would also seek an endoscopy/biopsy of the small bowel to check for damage to the villous lining, which is the gold standard diagnostic test for celiac disease.
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