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Has Anyone Had A 0 On The Ttg Blood Test?


no-more-muffins

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no-more-muffins Apprentice

I am seriously confused by some of my results. The more I have been researching things the more I think my blood tests may not be valid. I have heard that having a 0 on the tTG test seems suspicious, and that everyone pretty much has at least some tTG present if they sufficiently make IgA.

My total IgA was 115, (normal range 68-378)

My tTG was 0 (range 0-19 being normal)

I got tests from enterolab for gluten sensitivity that came back as a 6 (anything over a 10 is positive.)

My symptoms:

weight loss, short stature, failure to grow as a child, late puberty, anxiety, depression, eczema, constant nausea, frequent loose BM, hand tremors, joint pain, headaches, insomnia, fatigue, menstrual irregularities, periodontal disease, endometriosis (14 years ago).

I have seen improvement with a gluten-free diet.

My 21 month old dd was positively diagnosed at enterolab as having gluten sensitivity (18 units on the test).

Anyone have any insight on this? I can't figure out why my gluten tests at enterolab could be negative.


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Switch2GF Rookie

Blood tests are not the "official" way to diagnose, they are just an easy first step.

My dad's blood work also came up with a 0. They determined that some people's body just don't produce the antibody that they are looking for.

An endoscopy is the true way of diagnosing. If you and your doc want to be 100% sure, then this is the next step. Best of luck!

darlindeb25 Collaborator
An endoscopy is the true way of diagnosing. If you and your doc want to be 100% sure, then this is the next step.

This is not necessarily true either. A good share of doctors miss a diagnosis with the endoscopy. either they do not know what they are looking at, or they do not get enough samples, so many varitables.

Recently, Dr. Peter Green stated a positive blood test is proof. This is something new from him. I think soon, we will hear many new thoughts on gluten intolerance/celiac disease.

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    • lalan45
      You’re not crazy—some people have severe neurological and physical reactions to gluten, not just digestive issues. While testing can be tricky without eating gluten, documenting symptoms and seeing a specialist familiar with atypical celiac or gluten-related disorders can help. Your reactions are real, and it’s valid to be cautious.
    • SamAlvi
      Anti TTG (IgA) 2.430 U/mL Anti TTG (IgG) 288.2 U/mL
    • trents
      You might consider asking for a referral to a RD (Registered Dietician) to help with food choices and planning a diet. Even apart from any gluten issues, you will likely find there are some foods you need to avoid because of the shorter bowel but you may also find that your system may make adjustments over time and that symptoms may improve.
    • Ello
      I wish Dr’s would have these discussions with their patients. So frustrating but will continue to do research. Absolutely love this website. I will post any updates on my testing and results.  Thank you
    • trents
      Losing 12" of your small bowel is going to present challenges for you in nutritional uptake because you are losing a significant amount of nutritional absorption surface area. You will need to focus on consuming foods that are nutritionally dense and also probably look at some good supplements. If indeed you are having issues with gluten you will need to educate yourself as to how gluten is hidden in the food supply. There's more to it than just avoiding the major sources of gluten like bread and pasta. It is hidden in so many things you would never expect to find it in like canned tomato soup and soy sauce just to name a few. It can be in pills and medications.  Also, your "yellow diarrhea, constipation and bloating" though these are classic signs of a gluten disorder, could also be related to the post surgical shorter length of your small bowel causing incomplete processing/digestion of food.
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