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If Celiac Is Caught And Treated Early Is There Still Risk For Other Autoimmune?


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guest134 Apprentice

As some of you know I may be diagnosed with early celiac. If my ab's don't go down and it is proven celiac and we treat it am I still at risk for developing other autoimmune diseases? We already checked 15 different antibodies, negative for everything so as of right now it is just the possibility of early celiac. Thoughts?


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shadowicewolf Proficient

It is always possible to develop one. I think the fact that ya have one already puts ya at a slightly higher risk, but treating it early enough probably stopped it from getting any higher.

GottaSki Mentor

That is a very good question. I doubt anyone can give you odds on this one. All autoimmune disorders are top on my list for much more research needed.

What I can tell you is if your next round of antibody tests does not have lower numbers -- I would advise you (as I would my own children) -- to remove ALL gluten for at least three months - six is better - then test blood again to see if antibodies are reduced.

AI symptoms can occur with celiac disease - without "classic" symptoms.

You have done a great deal of research - I believe you will find a good path that will lead to health and limit the risks that gluten may cause you.

nvsmom Community Regular

From what I've read, yes, once your body has started making antibodies against itself you are more likely to develop another autoimmune disease than someone who does not have AI diseases. Some medical circles are even starting to classify the diseases into groups: celiac disease falls into the Type III Polyglandular Autoimmune Syndrome. Heres's a quick overview:

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It makes sense to me when I consider my own personal experiences because my immune system has attacked my intestine, thyroid and platelets, and I suspect it is attacking my soft connective tissues too.

Celiac disease is not the main link in this syndrome, it's thyroiditis that is the common disease. I do wonder if my celiac had been discovered earlier if I would have devloped my problems but after reading about all the diseases and how they often overlap, I kind of doubt it was the cause... although it might have helped it to appear earlier in my life that it might have otherwise.

This is just my opinion and interpretation of what I've read though. I could be way off.

ButterflyChaser Enthusiast

I was talking to a prof of Weil Cornell the other night, and she confirmed that a) we don't know much about these disorders, especially because they involve multiple organs, and B) it is more correct to talk of "a condition of autoimmunity" rather than of singular diseases, ie a body's tendency to attack its own tissues.

That said, you may create antibodies and never develop the disease: my endo has arthritis rheumatoid, and has had antithyroid antibodies for twenty years, but she never developed thyroid disease.

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    • trents
      So the tTG-IGA at 28 is positive for celiac disease. There are some other medical conditions that can cause elevated tTG-IGA but this is unlikely. There are some people for whom the dairy protein casein can cause this but by far the most likely cause is celiac disease. Especially when your small bowel lining is "scalloped". Your Serum IGA 01 (aka, "total IGA") at 245 mg/dl is within normal range, indicating you are not IGA deficient. But I also think it would be wise to take your doctor's advice about the sucraid diet and avoiding dairy . . . at least until you experience healing and your gut has had a chance to heal, which can take around two years. After that, you can experiment with adding dairy back in and monitor symptoms. By the way, if you want the protein afforded by dairy but need to avoid casein, you can do so with whey protein powder. Whey is the other major protein in dairy.
    • jenniber
      hi, i want to say thank you to you and @trents   . after 2 phone calls to my GI, her office called me back to tell me that a blood test was “unnecessary” and that we should “follow the gold standard” and since my biopsy did not indicate celiac, to follow the no dairy and sucraid diet. i luckily have expendable income and made an appt for the labcorp blood test that day. i just got my results back and it indicates celiac disease i think 😭   im honestly happy bc now i KNOW and i can go gluten free. and i am SO MAD at this doctor for dismissing me for a simple blood test that wouldn’t have cost her anything !!!!!!!!!!! im sorry, im so emotional right now, i have been sick my whole life and never knew why, i feel so much better already   my results from labcorp:   Celiac Ab tTG TIgA w/Rflx Test Current Result and Flag Previous Result and Date Units Reference Interval t-Transglutaminase (tTG) IgA 01 28 High U/mL 0-3 Negative 0 - 3 Weak Positive 4 - 10 Positive >10 Tissue Transglutaminase (tTG) has been identified as the endomysial antigen. Studies have demonstrated that endomysial IgA antibodies have over 99% specificity for gluten sensitive enteropathy. Immunoglobulin A, Qn, Serum 01 245 mg/dL 87-352
    • JoJo0611
      Thank you this really helped. 
    • Samanthaeileen1
      Okay that is really good to know. So with that being positive and the other being high it makes sense she diagnosed her even without the endoscopy. So glad we caught it early. She had so many symptoms though that to me it was clear something was wrong.   yeah I think we had better test us and the other kids as well. 
    • GlorietaKaro
      One doctor suggested it, but then seemed irritated when I asked follow-up questions. Oh well—
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