No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter




Ads by Google:



Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts

SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Dietary Supplementation with Probiotics may be Beneficial in Celiac Disease

Celiac.com 04/28/2008 - A life-long gluten-free diet is currently the only treatment for celiac disease. However, many foods thought to be gluten-free actually contain small amounts of gluten, making it difficult to maintain a truly gluten-free diet.

Gluten is made up of glutenin and gliadin proteins. Gliadin is only partially digested in the small intestine and the resulting peptides are responsible for the inflammation and intestinal tissue damage in people with celiac disease. Because probiotic bacteria have been shown to digest gluten proteins to harmless peptides, supplementation with probiotics may be beneficial for people with celiac disease.

To begin testing this hypothesis, researchers in Finland added probiotic bacteria to cultures of intestinal epithelial cells (cells that line the intestine) to determine their effect on gliadin-induced cellular damage. Gliadin-induced damage to intestinal epithelial cells includes increased permeability of the epithelial layer, alteration of tight junctions between cells (which controls the passage of materials across the intestinal wall), and structural changes such as “ruffling” of the cell edges. Two probiotic bacterial species were evaluated: Lactobacillus fermentum and Bifidobacterium lactis.

Ads by Google:

In this study, B. lactis was able to inhibit permeability caused by gliadin. Additionally, both B. lactis and L. fermentum were able to protect against cell ruffling and alterations in tight junctions. The bacteria alone (without gliadin) did not cause any significant changes to the intestinal epithelial cells.

Researchers concluded that Bifidobacterium lactis may be a useful addition to a gluten-free diet. Supplementation with this probiotic appears to be able to reduce the damage caused by eating gluten-contaminated foods and may even accelerate healing after initiating a gluten-free diet. It is important to note the researchers do not suggest that supplementation with probiotics could take the place of  a gluten-free diet in the treatment of celiac disease.

Lindfors et al.
Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture - Clin Exp Immunol. 2008 Apr 16.

 

 

Celiac.com welcomes your comments below (registration is NOT required).





Spread The Word







Related Articles



13 Responses:

 
Steven Stusek
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
28 Apr 2008 7:15:51 PM PDT
Very readable, concise.

 
Mary Ford
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
01 May 2008 8:41:52 AM PDT
This echoes what a nutritionist friend had suggested. She said I needed not just the yogurt with bacteria, but the live cultures, kept refrigerated, from health food stores.

 
Mary Kretzmann
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
01 May 2008 11:42:45 AM PDT
Very helpful. I have also found it to be true. Ive' been gluten free for 6 years, and I found that probiotics helped in the healing process.
Originally I used Primal Defense...And a couple of years ago I switched to home made kefir...that helped me enormously. The best web site is Dom's insite - Search google for 'real Kefir' and you will find it.

The kefir helped me finally get over my corn sensitivity - which I believe came from a damaged gut from the gluten....

 
Justin Credible
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
01 May 2008 1:17:19 PM PDT
Great article. I purchased 2 years worth of Acidophilus/Bifidus and can't wait to see how I react (staying on gluten-free diet of course).

 
Diane Hewitt
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
02 May 2008 2:36:59 AM PDT
I have found this to be very true. I drink a cup of Kefir (plain) every day and find that it is even better than yogurt in aiding my digestion.

 
Leslie Bragg
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
12 May 2008 2:20:56 PM PDT
Excellent article. Would love to see more info on this topic. I have been taking Healthy Trinity for two months with amazing results. I have had celiac for 9 years with limited healing of intestinal damage on gluten-free diet, I also have DH and am considered a highly sensitive celiac. Since I started the probiotics, my lab work is normal, I no longer have dangerously low levels of B12 and Folic acid. I'm absorbing nutrients again.

 
Ammar
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
13 May 2008 8:35:32 PM PDT
Its a very helpful article - I was diagnosed a celiac since 1994 and I'm very curious about Bifidobacterium lactis.

 
Julia Flynn
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
27 May 2008 5:12:37 AM PDT
I have found a probiotic/enzyme that works very well. It's called Digestive Enzymes and it's a powder mixed with water that dissolves and absorbs immediately. I couldn't live without it some days! This with Aloe juice is a life saver.

 
Tami
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
04 Mar 2010 11:52:35 AM PDT
Can you tell me which brand name? I've searched under "digestive enzymes" and bring up many brands with this same title.

Thank you so much!!

 
Tricia
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
16 Jun 2008 4:47:19 PM PDT
I was just diagnosed with Celiac Disease in April. I am going to try this.

 
Jill
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
01 May 2009 8:44:45 AM PDT
I'm including a link to the abstract on the Pub Med website. Always nice to read the original:
http://www.ncbi.nlm.nih.gov/pubmed/18422736

 
Jill
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
27 Jul 2009 8:40:04 AM PDT
Does anyone have a brand name probiotics that are safe for celiacs?

 
maria
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
28 Oct 2009 9:42:35 PM PDT
Very helpful.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:

All Activity
Celiac.com Celiac Disease & Gluten-Free Diet Forum - All Activity

you're lucky you dont catch colds. im the opposite i catch everything very easily and get alot sicker than whoever i caught it from and take much longer to get better.

Even one positive can be diagnostic. This is one: Gliadin deamidated peptide IgG 33.9. If unsure, a biopsy of the small intestine will provide definite confirmation. There is a control test to validate the other ones, but I don't see it there. What is does is validate the others by checking on the overall antibody levels. But it is to detect possible false negatives. A positive is a positive. I think your daughter has joined our club.

My daughter, almost 7 years old, recently had a lot of blood work done, her Dr is out of the office, but another Dr in the practice said everything looked normal. I'm waiting for her Dr to come back and see what she thinks. I'm concerned because there is one abnormal result and I can't find info to tell me if just that one test being abnormal means anything. The reason for the blood work is mainly because of her poor growth, though she does have some other symptoms. IgA 133 mg/dl Reference range 33-200 CRP <2.9 same as reference range Gliadin Deamidated Peptide IgA .4 Reference range <=14.9 Gliadin deamidated peptide IgG 33.9 Reference range <=14.9 TTG IgA .5 Reference range <=14.9 TTG IgG <.8 Reference range <=14.9

Just watch out. I just went to the expo in Schaumburg, IL, and ended up getting glutened. I realized afterward that I ate all these samples thinking they were gluten free, and they weren't. One company was advertising some sugar, and had made some cake, but then I realized.... How do I know if this contains any other ingredients that might have gluten? Did they make it with a blender or utensils that had gluten contamination? Makes me realize the only safe things would be packaged giveaways with gluten free labeling. My fault for not thinking things through. It was just too exciting thinking i could try it all and enjoy without worry.

No fasting required for a celiac blood test unless they were checking your blood glucose levels during the same blood draw.