Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Help Celiac.com:
    eNewsletter
    Donate
  • Record is Archived

    This article is now archived and is closed to further replies.

    Kathleen La Point
    Kathleen La Point

    Dietary Supplementation with Probiotics may be Beneficial in Celiac Disease

    Reviewed and edited by a celiac disease expert.

    Celiac.com 04/28/2008 - A life-long gluten-free diet is currently the only treatment for celiac disease. However, many foods thought to be gluten-free actually contain small amounts of gluten, making it difficult to maintain a truly gluten-free diet.

    Gluten is made up of glutenin and gliadin proteins. Gliadin is only partially digested in the small intestine and the resulting peptides are responsible for the inflammation and intestinal tissue damage in people with celiac disease. Because probiotic bacteria have been shown to digest gluten proteins to harmless peptides, supplementation with probiotics may be beneficial for people with celiac disease.

    To begin testing this hypothesis, researchers in Finland added probiotic bacteria to cultures of intestinal epithelial cells (cells that line the intestine) to determine their effect on gliadin-induced cellular damage. Gliadin-induced damage to intestinal epithelial cells includes increased permeability of the epithelial layer, alteration of tight junctions between cells (which controls the passage of materials across the intestinal wall), and structural changes such as “ruffling” of the cell edges. Two probiotic bacterial species were evaluated: Lactobacillus fermentum and Bifidobacterium lactis.

    Celiac.com Sponsor (A12):
    In this study, B. lactis was able to inhibit permeability caused by gliadin. Additionally, both B. lactis and L. fermentum were able to protect against cell ruffling and alterations in tight junctions. The bacteria alone (without gliadin) did not cause any significant changes to the intestinal epithelial cells.

    Researchers concluded that Bifidobacterium lactis may be a useful addition to a gluten-free diet. Supplementation with this probiotic appears to be able to reduce the damage caused by eating gluten-contaminated foods and may even accelerate healing after initiating a gluten-free diet. It is important to note the researchers do not suggest that supplementation with probiotics could take the place of  a gluten-free diet in the treatment of celiac disease.

    Lindfors et al.
    Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture - Clin Exp Immunol. 2008 Apr 16.

     

     



    User Feedback

    Recommended Comments



    Guest Steven Stusek

    Posted

    Very readable, concise.

    Link to comment
    Share on other sites
    Guest Mary Ford

    Posted

    This echoes what a nutritionist friend had suggested. She said I needed not just the yogurt with bacteria, but the live cultures, kept refrigerated, from health food stores.

    Link to comment
    Share on other sites
    Guest Mary Kretzmann

    Posted

    Very helpful. I have also found it to be true. Ive' been gluten free for 6 years, and I found that probiotics helped in the healing process.

    Originally I used Primal Defense...And a couple of years ago I switched to home made kefir...that helped me enormously. The best web site is Dom's insite - Search google for 'real Kefir' and you will find it.

     

    The kefir helped me finally get over my corn sensitivity - which I believe came from a damaged gut from the gluten....

    Link to comment
    Share on other sites
    Guest Justin Credible

    Posted

    Great article. I purchased 2 years worth of Acidophilus/Bifidus and can't wait to see how I react (staying on gluten-free diet of course).

    Link to comment
    Share on other sites
    Guest Diane Hewitt

    Posted

    I have found this to be very true. I drink a cup of Kefir (plain) every day and find that it is even better than yogurt in aiding my digestion.

    Link to comment
    Share on other sites
    Guest Leslie Bragg

    Posted

    Excellent article. Would love to see more info on this topic. I have been taking Healthy Trinity for two months with amazing results. I have had celiac for 9 years with limited healing of intestinal damage on gluten-free diet, I also have DH and am considered a highly sensitive celiac. Since I started the probiotics, my lab work is normal, I no longer have dangerously low levels of B12 and Folic acid. I'm absorbing nutrients again.

    Link to comment
    Share on other sites
    Guest Ammar

    Posted

    Its a very helpful article - I was diagnosed a celiac since 1994 and I'm very curious about Bifidobacterium lactis.

    Link to comment
    Share on other sites
    Guest Julia Flynn

    Posted

    I have found a probiotic/enzyme that works very well. It's called Digestive Enzymes and it's a powder mixed with water that dissolves and absorbs immediately. I couldn't live without it some days! This with Aloe juice is a life saver.

    Link to comment
    Share on other sites
    Guest Tricia

    Posted

    I was just diagnosed with Celiac Disease in April. I am going to try this.

    Link to comment
    Share on other sites
    Guest Jill

    Posted

    I'm including a link to the abstract on the Pub Med website. Always nice to read the original:

    Open Original Shared Link

    Link to comment
    Share on other sites
    Guest Jill
    I'm including a link to the abstract on the Pub Med website. Always nice to read the original:

    Open Original Shared Link

    Does anyone have a brand name probiotics that are safe for celiacs?

    Link to comment
    Share on other sites
    Guest maria

    Very helpful.

    Link to comment
    Share on other sites



    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Help Celiac.com:
    Donate
  • About Me

    Kathleen La Point

    Kathleen LaPoint is a biomedical writer with a B.S. in Molecular Biology and an M.S. in Bacteriology from the University of Wisconsin - Madison.


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Scott Adams
    Paul V, Henkerr J, Todt H, Eysold R.
    Z.Klin.Med., 1985; 40: 707-709.
    In this study 90 EEGs were performed on 58 celiac children. Researchers concluded that abnormal brain waves resulted from the ingestion of gluten by celiac children. They also concluded that a gluten challenge should not be given before a child reaches the age of 6 years old, and the challenge should not last longer than 5 months. The researchers main concern seems to be the risk of permanent brain damage that they believe could be caused in a celiac child who eats gluten for a prolonged period of time.


    Jefferson Adams
    Celiac.com 07/20/2010 - Anyone who's tried to maintain a gluten-free diet for celiac disease or other reasons can likely tell stories about the difficulties and challenges they face on a regular basis. Still, very little research has been done regarding the psychological and social challenges faced by people with celiac disease who are attempting to follow a gluten-free diet.
    Scientists in India recently conducted just such a study. A research team set out to assess psychological and social challenges faced by Indian children with celiac disease who are attempting to follow a gluten-free diet. The research team included Srikanta Basu, J. C. Chauhan, A. K. Dutta, Praveen Kumar, and Arun Kumar from the Division of Gastroenterology, Department of Pediatrics at Lady Hardinge Medical College...


  • Recent Activity

    1. - CatherineWang replied to B1rdL0ver's topic in Related Issues & Disorders
      40

      Dealing with constant nausea and just feeling awful.

    2. - cristiana replied to BunnyBrown's topic in Related Issues & Disorders
      3

      Recently had my esophagus dilated

    3. - cristiana replied to twe0708's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      54

      How Long Do Celiac Patients Live?

    4. - Exchange Students replied to Exchange Students's topic in Parents, Friends and Loved Ones of Celiacs
      2

      Exchange Students who are celiac in need of host

    5. - Scott Adams replied to Exchange Students's topic in Parents, Friends and Loved Ones of Celiacs
      2

      Exchange Students who are celiac in need of host


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      120,154
    • Most Online (within 30 mins)
      7,748

    Ohwowitsgluten
    Newest Member
    Ohwowitsgluten
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.2k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • Sunflowers06
      6
    • Momkaren
      10
    • Elizabeth M Blair
      5
    • B1rdL0ver
    • twe0708
      54
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...