No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Immune Phenotype of Children with Newly Diagnosed and Gluten-Free Diet-Treated Celiac Disease


New research on immune phenotypes and kids with celiac disease

Celiac.com 09/13/2010 - What's happening in with the immune system when a child is first diagnosed with celiac disease? What happens when they are treated with a gluten-free diet?

Some recent studies have indicated that both the adaptive and the innate immune system play roles in celiac disease. However, until now, doctors haven't known much about the immune phenotype of children with celiac disease and how that phenotype might by affected by a gluten-free diet.

To move toward a better understanding of these issues, a team of researchers recently studied immune phenotype in children with either newly diagnosed celiac disease, or celiac disease treated with a gluten-free diet.

The research team included Áron Cseh, Barna Vásárhelyi, Balázs Szalay, Kriszta Molnár, Dorottya Nagy-Szakál, András Treszl, Ádám Vannay, András Arató, Tivadar Tulassay and Gábor Veres. The are affiliated with the First Department of Pediatrics in the Research Group for Pediatrics and Nephrology at Semmelweis University and Hungarian Academy of Sciences, in Budapest, Hungary.

For their study, the team described the status of major players within the adaptive and innate immune system in peripheral blood of children with newly diagnosed celiac disease. They then looked to see how the phenotype might have changed
once the symptoms improved following treatment with a gluten-free diet.

Ads by Google:

The team drew peripheral blood samples from ten children with biopsy-proven celiac disease at the time of diagnosis and again after once clinical symptoms subsided with treatment by gluten-free diet. They also drew blood samples from a control group of 15 children who suffered from functional abdominal pain.

They measured the prevalence of cells of adaptive and innate immunity by means of labeled antibodies against surface markers and intracellular FoxP3 using a flow cytometer.

They found that patients with celiac disease had lower T helper, Th1 and natural killer (NK), NKT and invariant NKT cell prevalence and with higher prevalence of activated CD4+ cells, myeloid dendritic cells (DC) and Toll-like receptor (TLR) 2 and TLR-4 positive DCs and monocytes compared to controls.

Most of these deviations returned to normal, once symptoms subsided with gluten-free diet treatment. However, prevalence of NK and NKT cell, DC and TLR-2 expressing DCs and monocytes remained abnormal.

The immune phenotype in childhood celiac disease indicates that both adaptive and innate immune systems are playing a role in celiac disease.

Treatment with a gluten-free diet reverses immune abnormalities, but the mechanics of the reversal likely varies among cell types.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
jeannie lindsay
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
14 Sep 2010 6:07:33 AM PDT
Very much appreciate this information and assume the same phenomena occur in adults with celiac. Hope to see future studies on the consequences of this in regard to the incidence of other disease processes.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Thanks for letting me know. My back hurts all the time

I had a pillcam done two and a half months after I went gluten-free and it only showed gastropathy. three and a half months before the pillcam and endoscopy showed damage consistent with celiac. That damage was after a 10 or 11 week gluten challenge. prior to that I was gluten-free for a ...

It works much better for me but everyone is different. I have a physical job and sometimes get lower back pain. A hot shower and an Aleve will usually relieve it. It's worth your giving it a try.

Is Aleve better than ibuprofen? My back pain doesn't budge with 800 mg Motrin.

When I was diagnosed, I had only anemia. That is it. Later I found that I had osteoporosis as a result of untreated celiac disease. There are over 200 symptoms attributed to celiac disease. You may have many or NONE at all (called silent). After going gluten free within months my anemi...