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Could Egg Yolks Hold the Key to Celiac Disease Treatment?

Celiac.com 08/12/2015 - There are numerous pills, enzymes, and other products in development that are all designed to provide moderate protection against accidental gluten exposure to people with celiac disease to gluten-intolerance.

Photo: CC--Neil ConwayCan a new pill, which uses egg yolk antibodies to coat gluten, allowing it to pass from the body without harm, find a place on the crowded roster of contenders?

Driven by a desire to provide relief for people with celiac disease, Hoon Sunwoo, an associate professor of pharmaceutical sciences, has spent the last 10 years working on the proprietary pill.

If Hoon has his way, people with celiac disease may soon be able to enjoy bread, pasta and other gluten products without suffering headaches, digestion problems and severe intestinal damage that come with the adverse gluten reactions of celiac disease.

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The pill works by using egg yolk antibodies to coat the gluten and allow it to pass from the body without doing any damage. While not a cure, Sunwoo's pill, now under development at the University of Alberta, may allow those people to join friends for a beer and pizza.

Sunwoo makes it very clear that his pill is not a cure or long-term treatment solution, and the people with the disease should still follow a strict gluten-free diet.

The pill is designed to be eaten by a person with celiac disease five minutes before eating or drinking, and would provide protection from an adverse gluten reaction for the next one or two hours.

The pill completed safety clinical trials two months ago and is expected to begin efficacy clinical trials next year.

Read more at CBC.CA.

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3 Responses:

 
R Hodge
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
17 Aug 2015 7:57:07 AM PDT
Won't do this celiac patient any good, because I am also allergic to egg yolk.

 
Dawna
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
18 Aug 2015 8:56:42 AM PDT
Heck if it helps I'm all for it.

 
sc'Que?
Rating: ratingfullratingfullratingemptyratingemptyratingempty Unrated
said this on
19 Aug 2015 2:49:24 AM PDT
Sounds more like a "travel abroad" plan than a realistic one for daily use. Still... if it keeps the research plowing forward...




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It took me 20 years or more Barry so I wouldn't claim any great insight on this I had a 'eureka' moment, up until then I was walking around with multiple symptoms and not connecting any dots whatsoever. It is very, very difficult to diagnose and that's something that's reflected in so many of the experiences detailed here. A food diary may help in your case. It helped me to connect the gaps between eating and onset. It could help you to track any gluten sources should you go gluten free. It is possible for your reactions to change over time. As to whether its celiac, that's something you could explore with your doctor, stay on gluten if you choose to go that way. best of luck! Matt

I took Zoloft once. Loved it until it triggered microscopic colitis (colonoscopy diagnosed it). Lexapro did the same. However, I have a family member who is fiagnosed celiac and tolerates Celexa well.

Thanks for the update and welcome to the club you never wanted to join! ?

Jmg, I am glad you were able to come to the realisation that the culprit was in fact gluten. For me its not so simple. IBS runs in the family, as do several food intolerances. Its just in the last while that I can finally reach the conclusion that for me its gluten. The fact that it is a delayed effect-several hours after, made it harder. Friday I had some KFC, felt great. Saturday evening felt sleepy, Sunday felt awful and my belly was huge. I think I have gone from mildly sensitive to full blown celiac over the course of five years-if that possible. Thanks for all your help.

I thought I'd take a moment to provide an update, given how much lurking I've done on these forums the last year. It took a long time, but I've since had another gastroenterologist visit, many months of eating tons of bread, and an endoscopy where they took several biopsies. I have to say, the endoscopy was a super quick and efficient experience. During the procedure they let me know that it looked somewhat suspicious, causing them to take many biopsies, and then did comprehensive blood work. About a month later, I received a call telling me that the TTG came back positive a second time, and that the biopsies were a mix of negative (normal) results and some that were positive (showing blunting of the villi). As a result, I've been given a celiac diagnosis. It's been about a month now that I've been eating gluten free. Not sure if I'm really feeling all that different yet. It's a bit twisted to say, but in some way I was hoping for this diagnosis ? thinking how nice it would be to have an explanation, a plan of action, and feeling better. It's certainly no small change to be totally gluten free, but I'm hopeful.