ActoGeniX Is Progressing Toward Celiac Disease Treatment

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By Roy Jamron

April 20, 2008
By Roy Jamron • April 20, 2008

ActoGeniX Is Progressing Toward Celiac Disease Treatment

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Celiac.com 04/20/2008 - Open Original Shared Link is a recently formed Belgian company specializing in the development and use of genetically altered probiotic Lactococcus lactis bacteria designed to secrete and deliver therapeutic peptides and proteins to treat gastrointestinal disorders. Their product is called ActoBiotics™. Celiac disease is among the disorders ActoGeniX is currently investigating. Research has already shown efficacy in a celiac disease model where ActoBiotics™ continuously secrete small segments of gluten peptides to induce tolerance to gluten. Further research and trials are in the pipeline.

Shortly after the release of a recent paper by Italian researchers demonstrating that a peptide from durum wheat is able to completely suppress the immune response to gluten in a culture of celiac disease intestinal T cells (see Open Original Shared Link ), I contacted ActoGeniX to suggest they work with the Italian researchers to create an ActoBiotic™ designed to continuously secrete the durum wheat peptide as a therapy for celiac disease. ActoGeniX replied and was very interested in the durum wheat peptide, indicating it was possible for them to produce an ActoBiotic™ to secrete the durum wheat peptide and they would contact the Italian group. I also attempted to contact the Italian researchers to inform them about ActoGeniX, but they did not reply. I strongly believe that a collaboration between these two groups would result in the speediest and most successful development of a treatment which could effectively "cure" celiac disease through continuous secretion of the durum wheat peptide by genetically modified probiotic bacteria in the gut.

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ActoGeniX has recently totally revised their website which is now much more informative and includes short videos discussing ActoBiotics™ as well as a short video presentation of their celiac disease research. More about this article can be found on their website at Open Original Shared Link.

Technical information describing their product and initial research and development in detail is presented in the following patent application: Open Original Shared Link.
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Guest Ricardo Ferreira

Posted May 1, 2008

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LetÂ´s hope a treatment is available in a near future.

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Guest L.A. Sal

Posted May 13, 2008

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I sure hope there is a cure in the near future, but there's one thing that doesn't make sense:

I have read before about the benefits of probiotics for those of us with celiac, but the use of durum wheat of all things? That is difficult to get my head around, given that we can't have regular pasta, can't even have regular pasta touch gluten-free pasta.

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About Me

Roy S. Jamron holds a B.S. in Physics from the University of Michigan and an M.S. in Engineering Applied Science from the University of California at Davis, and independently investigates the latest research on celiac disease and related disorders.
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