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Can Some Celiac Disease Be Treated with More than Just a Gluten-free Diet?


Photo: CC--Brett Jordan

Celiac.com 08/05/2016 - Currently, a gluten free diet is the only option for treating celiac disease. Still, there are numerous patients who follow the diet, but do not respond fully clinically or histologically.

What options do doctors have to treat celiac disease beyond a gluten-free diet? A team of researchers wanted to find out. The research team includes S. Kurada, A. Yadav, and DA Leffler of the Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, and the Celiac Research Program at Harvard Medical School, and the Department of Medicine at Boston Medical Center’s Boston University School of Medicine in Boston, Massachusetts.

The team conducted a search of PubMed and clinicaltrials.gov to highlight celiac disease articles that use keywords including 'celiac disease' and 'refractory celiac disease' and focused on articles conducting pathophysiologic and therapeutic research in/ex-vivo models and human trials.

They then zeroed-in on developing therapies that influence these processes, including tight junction regulators, glutenases, gluten sequestrants and immunotherapy using vaccines, nanoparticles that may serve as adjuncts to a gluten-free diet, or maybe even allow for gluten consumption.

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Their subsequent paper also highlight the role of anti-inflammatories, immunosuppressants and monoclonal antibodies in refractory celiac disease.

According to the commentary of their expert, "therapies including tight junction regulators and glutenases have the potential to be approved for non-responsive celiac disease, or as gluten adjuncts."

The team expect results of various phase 1/2 trials using AMG 714, BL 7010, IgY antibodies to be published. In the interim, They plan to treat refractory celiac disease with off-label use of 5 amino-salicylates, budesonide, nucleoside analogues and newer biologics developed for other inflammatory diseases.

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3 Responses:

 
Lynn Holtmeyer
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
18 Aug 2016 6:43:27 AM PDT
I am currently facing a decision: Diagnosed with celiac in 2009. Last endoscopy in 2013 showed healing of small intestines, some duodenal scalloping still present.
I developed psoriasis vulgaris over 15% of my body. I am presently being offered Stelara as a treatment. How will this affect my celiac ...positive or negative?

 
Leaky gut
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
07 Nov 2016 5:53:40 AM PDT
A huge piece of the puzzle for me was reducing dairy and sugar consumption to minimal AND eliminating NSAIDs and other drugs that promote leaky gut.

 
Altinoy Kamilova
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
20 Mar 2017 9:25:14 AM PDT
Very interesting information.




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