Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

What do you make of my results?

Rocky73

Recommended Posts

Rocky73 Newbie
Rocky73
Posted

Hi All,

Was wondering whether you can help me interpret my results please. 

I do generally feel very good but have been plagued by some gastro issues on and off since beginning of July which I put down to stress but currently feeling great. Have also in parallel found out I was iron, vitamin d, magnesium and zinc deficient and currently taking supplements for all. 

My gastro did some blood tests and results came back as follows and I was wondering what you would make of it. Have an appointment scheduled for discussion and biopsy on Nov 4.

Deamidated Gliadin IgA <2 RU/ml  (Ref. <25 Negative)

Anti Tissue Transglutaminase  IGA 38.41 RU/ml (Ref. more than 20 RU/ml: Positive)

Immunoglobulin A 2.23 g/l (Ref. 0.7 to 4 g/l)

My question is if positive TTG is indicative of celiac shouldn't gliadin have been positive too??

Thanks for your answers!

Rocky 73

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


nvsmom Community Regular
nvsmom
Posted

Hi All,

Was wondering whether you can help me interpret my results please. 

I do generally feel very good but have been plagued by some gastro issues on and off since beginning of July which I put down to stress but currently feeling great. Have also in parallel found out I was iron, vitamin d, magnesium and zinc deficient and currently taking supplements for all. 

My gastro did some blood tests and results came back as follows and I was wondering what you would make of it. Have an appointment scheduled for discussion and biopsy on Nov 4.

Deamidated Gliadin IgA <2 RU/ml  (Ref. <25 Negative)

 

Anti Tissue Transglutaminase  IGA 38.41 RU/ml (Ref. more than 20 RU/ml: Positive)

 

Immunoglobulin A 2.23 g/l (Ref. 0.7 to 4 g/l)

 

 

My question is if positive TTG is indicative of celiac shouldn't gliadin have been positive too??

Thanks for your answers!

Rocky 73

No, I'm afraid not.  Celiacs who are positive in all tests appear to be a (large) minority. It is very common to be positive in one test, negative in a nother test, or even have a negative biopsy with positive tests (or vice versa).  That's part of the reason this pre-testing forum is so well used.  ;)

It is suggested that people get as many tests run as possible for that very reason.  Celiac tests are not perfect.  They miss up to a quarter (or more in the old AGA tests) of all celiacs.

The ttG IgA misses up to 25% of all celiacs but it's specificity (% of positives caused by celiac) is at about 95%. This means if you had a negative ttG IgA you still have a 25% chance of being a celiac.  A positive tTG IgA means you have a 5% chance of that (weak) positive being caused by another autoimmune issue or a sickness (it is almost always a weak positive though - a 21 for your labs).

The DGP IgA is a good test, but it can miss 4-18% of celiacs.  You could be one of those.

My guess is that you have celiac disease.  A positive is generally a positive. 

If you want to be sure then request more testing get the DGP IgG, tTG IgG, EMA IgA, and the endoscopic biopsy (6+ samples taken). You could also get genetic testing done for the DQ2 and DQ8 genes, but that will just tell you if you are in the higher risk group of developing celiac disease. About 97% of all celiacs have at least one of those genes.

How is your doctor handling it?

Rocky73 Newbie
Rocky73
Posted
  • Author

Thank you - makes a lot of sense when you put it like this. Will be really gutted if this is going to be final diagnosis though. I am quite shocked about it actually. It doesn't run in the  family and like I said I don't really have any symptoms at all at the moment so did not see this coming at all :mellow:

I am seeing the doctor on November 4 for the biopsy.. Have not spoken to her since lab test; only the nurse who called to schedule biopsy as soon as blood work came back.  Not sure whether she plans on running more blood tests when I go in but will definitely  mention it. 

Thanks again for answering - it's great to have forums like these!

 

cyclinglady Grand Master
cyclinglady
Posted

Thank you - makes a lot of sense when you put it like this. Will be really gutted if this is going to be final diagnosis though. I am quite shocked about it actually. It doesn't run in the  family and like I said I don't really have any symptoms at all at the moment so did not see this coming at all :mellow:

I am seeing the doctor on November 4 for the biopsy.. Have not spoken to her since lab test; only the nurse who called to schedule biopsy as soon as blood work came back.  Not sure whether she plans on running more blood tests when I go in but will definitely  mention it. 

Thanks again for answering - it's great to have forums like these!

 

Keep eating gluten until all testing is complete!  

squirmingitch Veteran
squirmingitch
Posted

I'm going to repeat what cyclinglady said because it bears repeating. CONTINUE EATING GLUTEN UNTIL YOU ARE SURE ALL TESTING IS COMPLETED. Otherwise you can get a false negative & you don't want that. 

BTW, you DO have symptoms.....

"iron, vitamin d, magnesium and zinc deficient"

Do you know what prolonged deficiency in these will do to you over time? We do. We've been there and further. You don't want to go there. It's like slowly dying. Also, you may think you don't have any symptoms but once you go gluten free you might just be surprised by the things you thought were normal but have disappeared.

nvsmom Community Regular
nvsmom
Posted

.... Also, you may think you don't have any symptoms but once you go gluten free you might just be surprised by the things you thought were normal but have disappeared.

That is so true! It's astonishing the wide variety of damage an innocent PB&J sandwich can cause.

Rocky73 Newbie
Rocky73
Posted
  • Author

yeah no worries about me not eating any gluten :rolleyes: I am eating loads at the moment. Making the most of it until I know for sure that I am one of you. Should I continue with the supplements too?

Will keep you posted on my biopsy results and final diagnosis and thanks again for all your replies. Really appreciate it! 

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


squirmingitch Veteran
squirmingitch
Posted

The supplements certainly won't hurt you at this point so go ahed & keep taking them. Down the line you'll want to make sure they're gluten free though.

Yes, please update us when you get results. 

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      131,171
    • Most Online (within 30 mins)
      7,748
    kyle68j
    Newest Member
    kyle68j
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • DAR girl
      Celiac and allergic to common subs and adds in prepared foods

      By DAR girl · Posted

      Looking for help sourcing gluten-free products that do not contain potato or corn derived ingredients. I have other autoimmune conditions (Psoriatic Arthritis and Sjogrens) so I’m looking for prepared foods as I have fatigue and cannot devote a lot of time to baking my own treats. 
    • Scott Adams
      Disregarded

      By Scott Adams · Posted

      I am so sorry you're going through this. It's completely understandable to feel frustrated, stressed, and disregarded after such a long and difficult health journey. It's exhausting to constantly advocate for yourself, especially when you're dealing with so many symptoms and positive diagnoses like SIBO, while still feeling unwell. The fact that you have been diligently following the diet without relief is a clear sign that something else is going on, and your doctors should be investigating other causes or complications, not dismissing your very real suffering. 
    • Oldturdle
      Paying for my own Celiac screening at WalkInLab so a positive result doesn’t become part of my medical history

      By Oldturdle · Posted

      It is just so sad that health care in the United States has come to this.  Health insurance should be available to everyone, not just the healthy or the rich.  My heart goes out to you.  I would not hesitate to have the test and pay for it myself.  My big concern would be how you could keep the results truly private.  I am sure that ultimately, you could not.  A.I. is getting more and more pervasive, and all data is available somewhere.  I don't know if you could give a fake name, or pay for your test with cash.  I certainly would not disclose any positive results on a private insurance application.  As I understand it, for an official diagnosis, an MD needs to review your labs and make the call.  If you end up in the ER, or some other situation, just request a gluten free diet, and say it is because you feel better when you don't eat gluten.      Hang in there, though.  Medicare is not that far away for you, and it will remove a lot of stress from your health care concerns.  You will even be able to "come out of the closet" about being Celiac!
    • plumbago
      Paying for my own Celiac screening at WalkInLab so a positive result doesn’t become part of my medical history

      By plumbago · Posted

      Yes, I've posted a few times about two companies: Request a Test and Ulta Labs. Also, pretty much we can all request any test we want (with the possible exception of the N protein Covid test and I'm sure a couple of others) with Lab Corp (or Pixel by Lab Corp) and Quest. I much prefer Lab Corp for their professionalism, ease of service and having it together administratively, at least in DC. And just so you know, Request a Test uses Lab Corp and Quest anyway, while Ulta Labs uses only Quest. Ulta Labs is cheaper than Request a Test, but I am tired of dealing with Quest, so I don't use them so much.
    • Scott Adams
      Does Dailymed.nlm.nih.gov site have filters for gluten?

      By Scott Adams · Posted

      PS - I think you meant this site, but I don't believe it has been updated in years: http://glutenfreedrugs.com/ so it is best to use: You can search this site for prescriptions medications, but will need to know the manufacturer/maker if there is more than one, especially if you use a generic version of the medication: To see the ingredients you will need to click on the correct version of the medication and maker in the results, then scroll down to "Ingredients and Appearance" and click it, and then look at "Inactive Ingredients," as any gluten ingredients would likely appear there, rather than in the Active Ingredients area. https://dailymed.nlm.nih.gov/dailymed/   
×
×
  • Create New...