Jump to content
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

IgG of 85


dyspepticgirl

Recommended Posts

dyspepticgirl Newbie

New around here, looking for help with some odd lab results.  Celiac serology panel done in 2010 (at age 13) by Quest.  Results:

Endomysial Antibody IgA: Negative

Gliadin Antibody IgA: 9 U/mL, within range of 9-11 U/mL

Gliadin Antibody IgG: 85 U/mL, outside of range of 9-11 U/mL

IgA: 223 mg/dL, within range of 70-432

 

 T Transglutaminase IgA <3 U/mL, within normal of <5

I was deemed negative for celiac by pediatrician, who never mentioned the abnormal IgG results.  Upper endoscopy with biopsy in 2011, I never got exact results but was told biopsy was negative for celiac.  GI who did the endoscopy actually misdiagnosed me with gastroparesis, diagnosis was corrected (by different GI doctor) in 2013 to functional dyspepsia with visceral hyperalgesia. My main symptoms since 2011 have been nausea, bloating, and excessive belching, though I have had chronic constipation nearly my entire life. Also noticing more intestinal pain and constipation the last few months, and then I found the celiac results from 2010 while going through medical records.  I've done a lot of digging on this site, and while I've seen a few people with similar results, I've never seen an IgG that high.  I'm fairly certain the test was an anti-gliadin antibody IgG, not the new deamidated one.  I know this result and the rest are not indicative of celiac disease, but does it mean my immune system is negatively reacting to gluten? Is it possible that gluten sensitivity could cause such an elevated IgG?  One of my grandparents is diagnosed with non-celiac gluten sensitivity.

Thank you!


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



cyclinglady Grand Master

Welcome!

2010 was a long time ago.  I would ask for a new celiac blood panel (complete one and not just the TTG) and be sure to include both the newer DGP iga and the DGP Igg.  Celiac disease can develop at any time and you might have just started to develop it.    Also, the small intestine is vast (size of a tennis court) and it is easy to miss damaged areas.  How many biopsies were taken?  You should have gotten four to six tissue samples.  Get copies of all your lab reports if  possible.  

Open Original Shared Link

Keep us posted!  We are here to help!  

dyspepticgirl Newbie
Just now, cyclinglady said:

Welcome!

2010 was a long time ago.  I would ask for a new celiac blood panel (complete one and not just the TTG) and be sure to include both the newer DGP iga and the DGP Igg.  Celiac disease can develop at any time and you might have just started to develop it.    Also, the small intestine is vast (size of a tennis court) and it is easy to miss damaged areas.  How many biopsies were taken?  You should have gotten four to six tissue samples.  Get copies of all your lab reports if  possible.  

Open Original Shared Link

Keep us posted!  We are here to help!  

Thank you for such a quick response!

I started keeping a food/symptom diary last week and will probably visit my original pediatrician in about a month to discuss this with her.  She is a great dr, very open minded and up to date.  I will ask to get a new panel.  I have no idea how many biopsies were taken or where they were taken from.  The peds GI doctors I have seen are from a different healthcare system without a handy online portal, but perhaps my regular doctor has the results somewhere.

Another question: do you know anything about celiac disease giving a positive anti-nuclear antibody result (since celiac is technically auto-immune)?  I tried to find some info but couldn't find much.  I had a weak positive ANA in 2012, but really no other auto-immune symptoms besides my digestive troubles, so the rheumatologist I visited said it was probably a fluke.  I agree that is possible, since many healthy people have a positive ANA test, but was just wondering if there was a connection.

cyclinglady Grand Master

Well, once you have one AI, you can develop more.  For example, I have both celiac disease (dx 2013) and Hashimoto's Thyroiditis (dx 1997).  I am hoping that I do not develop anymore!  I never had an ANA test.  Let's hope others will chime in.  

Gemini Experienced

Celiac disease can elevate ANA.  The test is not a test for anything specific but a test for general inflammation.   There are multiple AI diseases that will raise ANA.  Mine was sky high at diagnosis of Celiac and now, after 11 years gluten-free, it has improved dramatically.  But I have 4 AI diseases in total so I doubt it will ever be normal. I don't worry about it anymore.

Archived

This topic is now archived and is closed to further replies.


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      131,720
    • Most Online (within 30 mins)
      7,748

    Donna Spivey
    Newest Member
    Donna Spivey
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):




  • Who's Online (See full list)

    • There are no registered users currently online

  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • Rejoicephd
      @Scott Adams That's actually exactly what I ended up asking for— vodka tonic with Titos.  I saw on their website that Tito's is certified gluten-free (maybe many of the clear vodkas are, I don't know, I just happened to look up Tito's in advance). I should have actually specified the 'splash' though, because I think with the amount of tonic she put in there, it did still end up fairly sweet.  Anyway, I think I've almost got this drink order down!
    • Wends
      Be interesting to see the effects of dairy reintroduction with gluten. As well as milk protein sensitivity in and of itself the casein part particularly has been shown to mimic gluten in about 50% of celiacs. Keep us posted!
    • deanna1ynne
      She has been dairy free for six years, so she’d already been dairy free for two years at her last testing and was dairy free for the entire gluten challenge this year as well (that had positive results). However, now that we’re doing another biopsy in six weeks, we decided to do everything we can to try to “see” the effects, so we decided this past week to add back in dairy temporarily for breakfast (milk and cereal combo like you said).
    • Gigi2025
      Hi Christiana, Many thanks for your response.  Interestingly, I too cannot eat wheat in France without feeling effects (much less than in the US, but won't indulge nonetheless).  I also understand children are screened for celiac in Italy prior to starting their education. Wise idea as it seems my grandson has the beginning symptoms (several celiacs in his dad's family), but parents continue to think he's just being difficult.  Argh.  There's a test I took that diagnosed gluten sensitivity in 2014 via Entero Labs, and am planning on having done again.  Truth be told, I'm hoping it's the bromine/additives/preservatives as I miss breads and pastas terribly when home here in the states!  Be well and here's to our guts healing ❤️
    • Wends
      Lol that’s so true! Hope you get clarity, it’s tough when there’s doubt. There’s so much known about celiac disease with all the scientific research that’s been done so far yet practically and clinically there’s also so much unknown, still. Out of curiosity what’s her dairy consumption like? Even compared to early years to now? Has that changed? Calcium is dependent in the mechanism of antigen presenting cells in the gut. High calcium foods with gluten grains can initiate inflammation greater.  This is why breakfast cereals and milk combo long term can be a ticking time bomb for genetically susceptible celiacs (not a scientific statement by any means but my current personal opinion based on reasoning at present). Milk and wheat are the top culprits for food sensitivity. Especially in childhood. There are also patient cases of antibodies normalising in celiac children who had milk protein intolerance/ delayed type allergy. Some asymptomatic. There were a couple of cases of suspected celiacs that turned out to have milk protein intolerance that normalised antibodies on a gluten containing diet. Then there were others that only normalised antibodies once gluten and milk was eliminated. Milk kept the antibodies positive. Celiac disease is complicated to say the least.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.