IgG of 85

[dyspepticgirl]

New around here, looking for help with some odd lab results.  Celiac serology panel done in 2010 (at age 13) by Quest.  Results:

Endomysial Antibody IgA: Negative

Gliadin Antibody IgA: 9 U/mL, within range of 9-11 U/mL

Gliadin Antibody IgG: 85 U/mL, outside of range of 9-11 U/mL

IgA: 223 mg/dL, within range of 70-432

 

 T Transglutaminase IgA <3 U/mL, within normal of <5

I was deemed negative for celiac by pediatrician, who never mentioned the abnormal IgG results.  Upper endoscopy with biopsy in 2011, I never got exact results but was told biopsy was negative for celiac.  GI who did the endoscopy actually misdiagnosed me with gastroparesis, diagnosis was corrected (by different GI doctor) in 2013 to functional dyspepsia with visceral hyperalgesia. My main symptoms since 2011 have been nausea, bloating, and excessive belching, though I have had chronic constipation nearly my entire life. Also noticing more intestinal pain and constipation the last few months, and then I found the celiac results from 2010 while going through medical records.  I've done a lot of digging on this site, and while I've seen a few people with similar results, I've never seen an IgG that high.  I'm fairly certain the test was an anti-gliadin antibody IgG, not the new deamidated one.  I know this result and the rest are not indicative of celiac disease, but does it mean my immune system is negatively reacting to gluten? Is it possible that gluten sensitivity could cause such an elevated IgG?  One of my grandparents is diagnosed with non-celiac gluten sensitivity.

Thank you!

[cyclinglady]

Welcome!

2010 was a long time ago.  I would ask for a new celiac blood panel (complete one and not just the TTG) and be sure to include both the newer DGP iga and the DGP Igg.  Celiac disease can develop at any time and you might have just started to develop it.    Also, the small intestine is vast (size of a tennis court) and it is easy to miss damaged areas.  How many biopsies were taken?  You should have gotten four to six tissue samples.  Get copies of all your lab reports if  possible.  

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Keep us posted!  We are here to help!  

[dyspepticgirl]

Just now, cyclinglady said:

Welcome!

2010 was a long time ago.  I would ask for a new celiac blood panel (complete one and not just the TTG) and be sure to include both the newer DGP iga and the DGP Igg.  Celiac disease can develop at any time and you might have just started to develop it.    Also, the small intestine is vast (size of a tennis court) and it is easy to miss damaged areas.  How many biopsies were taken?  You should have gotten four to six tissue samples.  Get copies of all your lab reports if  possible.  

Open Original Shared Link

Keep us posted!  We are here to help!  

Thank you for such a quick response!

I started keeping a food/symptom diary last week and will probably visit my original pediatrician in about a month to discuss this with her.  She is a great dr, very open minded and up to date.  I will ask to get a new panel.  I have no idea how many biopsies were taken or where they were taken from.  The peds GI doctors I have seen are from a different healthcare system without a handy online portal, but perhaps my regular doctor has the results somewhere.

Another question: do you know anything about celiac disease giving a positive anti-nuclear antibody result (since celiac is technically auto-immune)?  I tried to find some info but couldn't find much.  I had a weak positive ANA in 2012, but really no other auto-immune symptoms besides my digestive troubles, so the rheumatologist I visited said it was probably a fluke.  I agree that is possible, since many healthy people have a positive ANA test, but was just wondering if there was a connection.

[cyclinglady]

Well, once you have one AI, you can develop more.  For example, I have both celiac disease (dx 2013) and Hashimoto's Thyroiditis (dx 1997).  I am hoping that I do not develop anymore!  I never had an ANA test.  Let's hope others will chime in.  

[Gemini]

Celiac disease can elevate ANA.  The test is not a test for anything specific but a test for general inflammation.   There are multiple AI diseases that will raise ANA.  Mine was sky high at diagnosis of Celiac and now, after 11 years gluten-free, it has improved dramatically.  But I have 4 AI diseases in total so I doubt it will ever be normal. I don't worry about it anymore.