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Scott Adams

Researchers Make Major Headway in Mapping Genetic Mutations in EATL

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Enteropathy-associated T cell lymphoma (EATL) subtypes are characterized by loss of function of SETD2. Although EATL is rare condition, it is deadly. It is also the most common neoplastic complication of celiac disease.

A team of researchers recently conducted whole-exome sequencing of 69 EATL tumors, which helped them to define the genetic landscape of EATL. They found that SETD2 was silenced in 32% of EATL patients, making it the most frequently silenced gene in EATL.

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Scott Adams

Celiac.com - Celiac Disease Board Moderator

Founder Celiac.com

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