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Scott Adams

Suppressive Function of Regulatory T Cells Impaired in Celiac Patients

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Circulating gluten-specific FOXP3+CD39+ regulatory T cells have impaired suppressive function in patients with celiac disease. What does that mean?

Although researchers understand the effector T-cell response in patients with celiac disease pretty well, they really don’t know very much about the role played by regulatory T cells (Treg cells) in the loss of tolerance to gluten. To get a better picture, a team of researchers recently set out to define whether patients with celiac disease have a dysfunction or lack of gluten-specific forkhead box protein 3 (FOXP3)+ Treg cells.

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