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- Aretaeus Cappadocia replied to drjay's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms2Unsteady in my new diagnosis
@drjay in addition to what @trents wrote, I wanted to comment on your statement, "Positive for DQ2 and homozygous for DQB1*02 but negative for DQ8" You don't need DQ2 >and< DQ8 in order to be susceptible to getting celiac. Either one is good enough. DQB1*02 is a specific genetic allele that encodes part of the DQ2 protein. "Homozygous" means... -
- trents replied to drjay's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms2Unsteady in my new diagnosis
@drjay, your mixed test results experience is exceedingly common for someone having been consuming reduced amounts of gluten. A Marsh scale score of 3 indicates "significant villous atrophy" according to a quick google search I did and the biopsy is the gold standard diagnostic test anyway, not the blood antibody testing. It doesn't look like a "total IGA...- 1
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- drjay posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms2Unsteady in my new diagnosis
About 2 years ago I got a referral to a GI because I was experiencing gut pain, bloating, and some other not so fun symptoms. He scheduled a colonoscopy and that came back fine with the exception of very small healing ulcers in my TI. I have a family history of stomach ulcers so I was prescribed a round of antibiotics and then placed on a PPI w/o an endoscopy... -
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- knitty kitty replied to smiths's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms29Struggling with gluten challenge and not sure it’s worth it - looking for advice / experiences / encouragement
I found these articles interesting. Among people already diagnosed with Celiac Disease, the HLA DQ B1*02 allele is present in about 95%...... Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening https...- 1
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By Aretaeus Cappadocia · Posted
@drjay in addition to what @trents wrote, I wanted to comment on your statement, "Positive for DQ2 and homozygous for DQB1*02 but negative for DQ8" You don't need DQ2 >and< DQ8 in order to be susceptible to getting celiac. Either one is good enough. DQB1*02 is a specific genetic allele that encodes part of the DQ2 protein. "Homozygous" means two copies of the same allele (the opposite is "heterozygous", where the two copies are different alleles). If you are homozygous for DQB1*02, you couldn't have DQ8. In other words, your genetic test tells you that you definitely have the potential to get celiac. -
@drjay, your mixed test results experience is exceedingly common for someone having been consuming reduced amounts of gluten. A Marsh scale score of 3 indicates "significant villous atrophy" according to a quick google search I did and the biopsy is the gold standard diagnostic test anyway, not the blood antibody testing. It doesn't look like a "total IGA" blood test was ordered and without that we cannot tell if you are IGA deficient. If IGA deficient, other celiac IGA antibody scores, such as the tTG-IGA, cannot be trusted. They will likely be artificially low. And given the fact that there is significant improvement in your symptoms once you went on a strict gluten free diet, there is no doubt in my mind that your doctor's diagnosis of celiac disease is the correct one. By the way, welcome to celiac.com.!
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About 2 years ago I got a referral to a GI because I was experiencing gut pain, bloating, and some other not so fun symptoms. He scheduled a colonoscopy and that came back fine with the exception of very small healing ulcers in my TI. I have a family history of stomach ulcers so I was prescribed a round of antibiotics and then placed on a PPI w/o an endoscopy to confirm. I think I may have convinced myself it was helping for about a year but I likely just acclimated to how I was feeling. Fast forward to January and my symptoms had gotten to be persistently unbearable and nothing was helping except some minor pressure relief from gasx. I get another appt with the GI and get an endoscopy done. There’s no ulcer so I stop the PPI and we do a SIBO test which comes back negative. The Dr orders a Labcorp celiac test immediately after he gets the biopsy results w/o the gluten challenge thing. I already don’t consume much if any because I suspected I may be sensitive to gluten. They grade the biopsy Marsh class 3 but my lab tests are weird and listed below IgA 11 (weak positive is 19) IgG 5 (weak positive is 19) tTG IgA 3 (weak positive 4) Positive for DQ2 and homozygous for DQB1*02 but negative for DQ8 My GI did diagnose as Celiac but the blood test makes me unsure. Even though I’ve been unsure, I immediately went on a strict gluten free diet. Yesterday makes 12 days and it was the first day with a normal bowel movement in last several weeks. Anyone have similar experience?
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By knitty kitty · Posted
I found these articles interesting. Among people already diagnosed with Celiac Disease, the HLA DQ B1*02 allele is present in about 95%...... Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening https://pubmed.ncbi.nlm.nih.gov/32256023/ Total IgA levels can be affected by the same HLA DQ B1*02 allele..... Total serum IgA levels and HLA-DQB1*02:01 allelic status https://pubmed.ncbi.nlm.nih.gov/37725324/ -
By Scott Adams · Posted
This new company claims to offer the most comprehensive genetic tests on the market for celiac disease, and we'll be doing a product review article (sponsored) on them soon.
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