Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Mixed results in child

suzeo

Recommended Posts

suzeo Newbie
suzeo
Posted

Hi,

 

I'm trying to sort out my 11 year old daughter who has a lot of stomach pain and belching.  Her IGG and IGA were both positive 203 and 68 (above 25 positive at this lab) her TTG was negative and her biopsy was negative.  What does this mixed result mean?

 

Thanks for your insight,

 

Susan

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


cyclinglady Grand Master
cyclinglady
Posted
22 minutes ago, suzeo said:

Hi,

 

I'm trying to sort out my 11 year old daughter who has a lot of stomach pain and belching.  Her IGG and IGA were both positive 203 and 68 (above 25 positive at this lab) her TTG was negative and her biopsy was negative.  What does this mixed result mean?

 

Thanks for your insight,

 

Susan

Welcome.  I think that the IgA and IgG tests are ordered as control tests for celiac disease testing.  If in range (or close to it), the TTG IgA and the TTG IgG tests are considered to be valid (results accurate).  Those tests also let a doctor know if there is an immune system issue.  You are talking about immunoglobulin tests, right?   The EMA and DGP celiac tests are missing.  What made the doctor move forward with biopsies if the TTG screening test was negative?  

A negative biopsy is possible as the small intestine is vast (size if a tennis court).  Patches of damage can be missed.

What did the doctor say?  Was anything found (e.g. SIBO, H. Pylori, etc)?  

  • 2 weeks later...
suzeo Newbie
suzeo
Posted
  • Author

Thank you for your reply.

Attached are the actual lab results.  Doctor has been hearing of more mixed lab results lately so did the biopsy.  He thinks maybe she is pre-celiac.  H Pylori was negative.  Everything else in scope was negative but showed evidence of irritation from reflux.  We are trying gluten free but understand that this will not allow a future diagnosis unless she goes off it again.  I just hate to do gluten-free with an 11 year old for the foreseeable future without  a real reason.

 

test results.png

tessa25 Rising Star
tessa25
Posted

She has a high for two tests, DGP IGA and DGP IGG. There are people on this forum with high DGP and normal TTG who have celiac. The biopsy results should confirm it for you. Did the pathology report from the biopsies come back yet? Maybe it did and I misunderstood?

?

cyclinglady Grand Master
cyclinglady
Posted
40 minutes ago, suzeo said:

Thank you for your reply.

Attached are the actual lab results.  Doctor has been hearing of more mixed lab results lately so did the biopsy.  He thinks maybe she is pre-celiac.  H Pylori was negative.  Everything else in scope was negative but showed evidence of irritation from reflux.  We are trying gluten free but understand that this will not allow a future diagnosis unless she goes off it again.  I just hate to do gluten-free with an 11 year old for the foreseeable future without  a real reason.

 

test results.png

Wow!  Those were not just Immunoglobulin tests.  Those were actually celiac antibodies tests!  I wonder why the (AGA) IgA was not flagged as a high result?  Your daughter's results were comparable to mine.    I test ONLY to the DGP IgA  (gliadin) even in follow-up testing.  Her results are very high!  My biopsy did reveal damage.  Do you know if they took enough biopsies?  Six or more is best.  Remember, it is easy to miss damaged areas.  I would ask for a copy of the pathologist's report to confirm the number of biopsies. 

The TTG can be elevated for other reasons.  I have yet to find elevated DGP (Gliadin) elevated for other than celiac disease.  That is strange.   I wonder if it is a lab typo?  

Okay, back to your  daughter.  You should seek a second GI opinion.   If she does have celiac disease, this is a critical time for growth.  A strict gluten-free diet can eliminate long term complications.  

 I guess the plan is to do the diet and then retest her antibodies?  

cyclinglady Grand Master
cyclinglady
Posted

Here why I think you should continue to advocate for your daughter's health.  This is not related to celiac disease.  My niece was diagnosed with Crohn's.  We thought for sure she had either the family gallbladder curse or celiac disease.  Everything was negative.  Nothing found.  Four GIs (two were PED GIs).  Finally the fourth GI did a pill camera.  Caught severe damage way beyond the reach of either scope.  She is doing well now with treatment. 

Her Mom did not settle.  She knew that her daughter's symptoms were real.  So, listen to your "Mom Radar".  Something is wrong.  Unfortunately, your daughter's case is not clear cut.  So, more research and medical advice is needed.  

Oh, the pill camera is being used as another diagnostic tool for celiac disease.  Something to research.  

 

cyclinglady Grand Master
cyclinglady
Posted

Sorry, I keep looking at the lab results.  The AGA (Anti-Gliadin)is an older test which has been replaced by the DGP test years ago.  Do you think your doctor ran the old tests?  I assumed the lab was using the old name, but that the celiac test was new.  In any case, it is still very positive but it makes me wonder how celiac-savvy your GI is.  

These are the current tests:

Open Original Shared Link

Can anyone else on the forum clarify?  

.....so, I found this about the old AGA tests.  It looks like other issues like liver disorders, IBS or other immune issues can associated with an elevated AGA.  Look at Mistake #9  (EU GI group): 

Open Original Shared Link

 

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      131,162
    • Most Online (within 30 mins)
      7,748
    Jean Kemling
    Newest Member
    Jean Kemling
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • DAR girl
      Celiac and allergic to common subs and adds in prepared foods

      By DAR girl · Posted

      Looking for help sourcing gluten-free products that do not contain potato or corn derived ingredients. I have other autoimmune conditions (Psoriatic Arthritis and Sjogrens) so I’m looking for prepared foods as I have fatigue and cannot devote a lot of time to baking my own treats. 
    • Scott Adams
      Disregarded

      By Scott Adams · Posted

      I am so sorry you're going through this. It's completely understandable to feel frustrated, stressed, and disregarded after such a long and difficult health journey. It's exhausting to constantly advocate for yourself, especially when you're dealing with so many symptoms and positive diagnoses like SIBO, while still feeling unwell. The fact that you have been diligently following the diet without relief is a clear sign that something else is going on, and your doctors should be investigating other causes or complications, not dismissing your very real suffering. 
    • Oldturdle
      Paying for my own Celiac screening at WalkInLab so a positive result doesn’t become part of my medical history

      By Oldturdle · Posted

      It is just so sad that health care in the United States has come to this.  Health insurance should be available to everyone, not just the healthy or the rich.  My heart goes out to you.  I would not hesitate to have the test and pay for it myself.  My big concern would be how you could keep the results truly private.  I am sure that ultimately, you could not.  A.I. is getting more and more pervasive, and all data is available somewhere.  I don't know if you could give a fake name, or pay for your test with cash.  I certainly would not disclose any positive results on a private insurance application.  As I understand it, for an official diagnosis, an MD needs to review your labs and make the call.  If you end up in the ER, or some other situation, just request a gluten free diet, and say it is because you feel better when you don't eat gluten.      Hang in there, though.  Medicare is not that far away for you, and it will remove a lot of stress from your health care concerns.  You will even be able to "come out of the closet" about being Celiac!
    • plumbago
      Paying for my own Celiac screening at WalkInLab so a positive result doesn’t become part of my medical history

      By plumbago · Posted

      Yes, I've posted a few times about two companies: Request a Test and Ulta Labs. Also, pretty much we can all request any test we want (with the possible exception of the N protein Covid test and I'm sure a couple of others) with Lab Corp (or Pixel by Lab Corp) and Quest. I much prefer Lab Corp for their professionalism, ease of service and having it together administratively, at least in DC. And just so you know, Request a Test uses Lab Corp and Quest anyway, while Ulta Labs uses only Quest. Ulta Labs is cheaper than Request a Test, but I am tired of dealing with Quest, so I don't use them so much.
    • Scott Adams
      Does Dailymed.nlm.nih.gov site have filters for gluten?

      By Scott Adams · Posted

      PS - I think you meant this site, but I don't believe it has been updated in years: http://glutenfreedrugs.com/ so it is best to use: You can search this site for prescriptions medications, but will need to know the manufacturer/maker if there is more than one, especially if you use a generic version of the medication: To see the ingredients you will need to click on the correct version of the medication and maker in the results, then scroll down to "Ingredients and Appearance" and click it, and then look at "Inactive Ingredients," as any gluten ingredients would likely appear there, rather than in the Active Ingredients area. https://dailymed.nlm.nih.gov/dailymed/   
×
×
  • Create New...