Help with understanding biopsy and blood test reports

[MikeMacKay]

I want to share my blood test results as well as my endoscopy to know from the forum if you think it's indicative of not being celiac disease or if you think I should be tested again. 

Here are some of the results I got back which was in 2017: 

Celiac Disease - Serum/Plasma (Final) 

Gliadin Antibody IgG    Less than 0.5          <12.0
Negative
IgG antibody to demiadated gliadin has approximately 95 per cent sensitivity and 95 per cent specificity for celiac disease. Deamidated gliadin IgG has particular utility in the detection of celiac disease in children younger than 2 years old and those with IgA deficiency. Tested by a multiplex flow immunoassay (Bioplex) method. 

- Tissue Transglutaminase antibody IgA     Less than 0.5      <12.0 

Negative 

IgA antyibody to tissue transglutaminase has approximately 95 per cent sensitivity and 95 per cent specificity for celiac disease. False negative results may occur with a gluten-restricted diet or iGa deficiency. The Bioplex method includes an internal control to confirm IgA is sufficient, thus avoiding false negatives due to IgA deficiency. 

Tested by a multiplex flow immunoassay (Bioplex) method.

Immunoglobins - Serum/Plasma (Final)

-IGG .       11.44               6.50-16.000 g/L
-IGA .        3.31 .               0.40-3.50 . g/L
- IGM .      0.56 .               0.50-3.00 g/L

 

Preoperative diagnosis: epigastric pain 

Postoperative diagnosis: antral erosions 

Procedure: The esophagus was intubated under direct vision. The esophagus was normal. The fundus and body were normal. The antrum showed some very small antral erosions. The duodenal cap and second and third part were normal. Biosipes were taken of the duodenum and cap. On retroflexion , the cardia and GE were normal.  There were some small antral erosions detected. Biospies were taken from the antrum. Upon withdrawl, the esophagus was normal. 

 

Biospy

Final diagnosis 

- no pathology diagnosis 
-negative for specific pathogens or villous atrophy 

gastric biopsy 

antral and body type mucosa

no pathology diagnosis 

negative for heliobacter pylori 

And it looks like 4 pieces were taken from the gastric biospy for and 4 pieces for the small bowel biopsy 

Can anyone make anything of what the results may indicate?  Do you think the results are pretty indicative or do you think I should be retested? 

Of note: all blood tests and procedures were done after being on the gluten diet for 8-12 weeks.

 

 

 

 

 

 

[cyclinglady]

9 hours ago, MikeMacKay said:

I want to share my blood test results as well as my endoscopy to know from the forum if you think it's indicative of not being celiac disease or if you think I should be tested again. 

Here are some of the results I got back which was in 2017: 

Celiac Disease - Serum/Plasma (Final) 

Gliadin Antibody IgG    Less than 0.5          <12.0
Negative
IgG antibody to demiadated gliadin has approximately 95 per cent sensitivity and 95 per cent specificity for celiac disease. Deamidated gliadin IgG has particular utility in the detection of celiac disease in children younger than 2 years old and those with IgA deficiency. Tested by a multiplex flow immunoassay (Bioplex) method. 

- Tissue Transglutaminase antibody IgA     Less than 0.5      <12.0 

Negative 

IgA antyibody to tissue transglutaminase has approximately 95 per cent sensitivity and 95 per cent specificity for celiac disease. False negative results may occur with a gluten-restricted diet or iGa deficiency. The Bioplex method includes an internal control to confirm IgA is sufficient, thus avoiding false negatives due to IgA deficiency. 

Tested by a multiplex flow immunoassay (Bioplex) method.

Immunoglobins - Serum/Plasma (Final)

-IGG .       11.44               6.50-16.000 g/L
-IGA .        3.31 .               0.40-3.50 . g/L
- IGM .      0.56 .               0.50-3.00 g/L

 

Preoperative diagnosis: epigastric pain 

Postoperative diagnosis: antral erosions 

Procedure: The esophagus was intubated under direct vision. The esophagus was normal. The fundus and body were normal. The antrum showed some very small antral erosions. The duodenal cap and second and third part were normal. Biosipes were taken of the duodenum and cap. On retroflexion , the cardia and GE were normal.  There were some small antral erosions detected. Biospies were taken from the antrum. Upon withdrawl, the esophagus was normal. 

 

Biospy

Final diagnosis 

- no pathology diagnosis 
-negative for specific pathogens or villous atrophy 

gastric biopsy 

antral and body type mucosa

no pathology diagnosis 

negative for heliobacter pylori 

And it looks like 4 pieces were taken from the gastric biospy for and 4 pieces for the small bowel biopsy 

Can anyone make anything of what the results may indicate?  Do you think the results are pretty indicative or do you think I should be retested? 

Of note: all blood tests and procedures were done after being on the gluten diet for 8-12 weeks.

 

 

 

 

 

 

I am not a doctor, but the celiac blood tests, the endoscopy and the biopsies did not reveal celiac disease.  Could they have missed damage in small intestine?  Maybe.  You could ask for the rest of the celiac panel which includes the TTG IgG, DGP IgA and the EMA.  Or find out the cause of your ulcer-like erosions (e.g. taking too many NSAIDS).  I hope you figure it out.