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Igg And Tissue Transglutemaninase Levels

sillyyak

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sillyyak Enthusiast
sillyyak
Posted

I got my IgG and Transglutaminase levels reports

My IgG was 40.6 with the normal reference range being between 0 - 29.9

My transglutaminase was 16.9 with the normal being lower tha 7.0

These seem quite high and wanted to know what others had?

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Carriefaith Enthusiast
Carriefaith
Posted

I had the tissue transglutamase test and I believe that my number was around 20.

2Boys4Me Enthusiast
2Boys4Me
Posted

I have to admit I'm not sure which tests my son had, but they were represented in a ratio.

Anything less than 1 : 2.5 is negative for Celiac (Mom, Dad and big brother).

Ty's was 1 : 650.

Yikes! We have a follow up soon, so I'll ask for a look at all the paperwork. At the original test and first follow up we were all so overwhelmed, it didn't occur to me to ask about the tests that were run.

Canadian Karen Community Regular
Canadian Karen
Posted

Mine was (I can't remember which test it was, Tt IgA or something like that.....) was well over 100.....

Karen

  • 2 weeks later...
KaitiUSA Enthusiast
KaitiUSA
Posted

My tTG was over 10 and the normal was below 4

chrissy Collaborator
chrissy
Posted

i got tTG results from our doc today. he told me normal is less than .7 kassie was 18.7, and molly was 22.8. he couldn't remember tianna's, but he said it was in the same neighborhood has the other 2 girls. i asked about there being no damage in the biopsies, but he said that they probably do have damage. the damage can be spotty, and if you miss it you don't see it. their numbers indicate that there is damage.

christine

Caeli Rookie
Caeli
Posted

Mt IgG was 11 units (negative)

My IgA was 34 units (Positive)

My Tissue Transglutaminase IgA was 99 units.

My biopsy indicated "sever partial to near total villous atrophy"

I am 51 years of age and was only diagnosed nearly 4 weeks ago. I suspect I have been suffering from Coeliac disease most of my life, certainly for the past 20 years. Doctor after doctor said it was IBS!! Now at last I have found that it wasn't all in the kind! I thought I was a hypochondriac! Apsrt from not feeling physically well and wasting money on unprofessional doctors, I have also spent years seeking help for depression and anxiety (again spending thousands of dollars seeking help). It will be interesting to see if the anxiety and depression lifts to some degree as I try to stick to the gluten-free diet.

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covsooze Enthusiast
covsooze
Posted
Mt IgG was 11 units (negative)

My IgA was 34 units (Positive)

My Tissue Transglutaminase IgA was 99 units.

My biopsy indicated "sever partial to near total villous atrophy"

I am 51 years of age and was only diagnosed nearly 4 weeks ago. I suspect I have been suffering from Coeliac disease most of my life, certainly for the past 20 years. Doctor after doctor said it was IBS!! Now at last I have found that it wasn't all in the kind! I thought I was a hypochondriac! Apsrt from not feeling physically well and wasting money on unprofessional doctors, I have also spent years seeking help for depression and anxiety (again spending thousands of dollars seeking help). It will be interesting to see if the anxiety and depression lifts to some degree as I try to stick to the gluten-free diet.

Hi Caeli

I've had positive blood results and am waiting for the biopsy before going gluten-free. Just wanted to say though that what you said strikes a real chord with me - the whole being a hypochondriac bit and having depression and anxiety. here's to a healthy furture for us :D

dbpark Newbie
dbpark
Posted
Mt IgG was 11 units (negative)

My IgA was 34 units (Positive)

My Tissue Transglutaminase IgA was 99 units.

My biopsy indicated "sever partial to near total villous atrophy"

I am 51 years of age and was only diagnosed nearly 4 weeks ago. I suspect I have been suffering from Coeliac disease most of my life, certainly for the past 20 years. Doctor after doctor said it was IBS!! Now at last I have found that it wasn't all in the kind! I thought I was a hypochondriac! Apsrt from not feeling physically well and wasting money on unprofessional doctors, I have also spent years seeking help for depression and anxiety (again spending thousands of dollars seeking help). It will be interesting to see if the anxiety and depression lifts to some degree as I try to stick to the gluten-free diet.

Sorry for the previous blank reply...this is my first post!

My TTga was in the 290s when first tested a year ago. Anybody have results like that??

Hi Caeli

I've had positive blood results and am waiting for the biopsy before going gluten-free. Just wanted to say though that what you said strikes a real chord with me - the whole being a hypochondriac bit and having depression and anxiety. here's to a healthy furture for us :D

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    • knitty kitty
      High DGP-A with normal IGA

      By knitty kitty · Posted

      @rei.b,  I understand how frustrating starting a new way of eating can be.  I tried all sorts of gluten-free processed foods and just kept feeling worse.  My health didn't improve until I started the low histamine AIP diet.  It makes a big difference.   Gluten fits into opioid receptors in our bodies.  So, removing gluten can cause withdrawal symptoms and reveals the underlying discomfort.  SIBO can cause digestive symptoms.  SIBO can prevent vitamins from being absorbed by the intestines.  Thiamine insufficiency causes Gastrointestinal Beriberi (bloating, abdominal pain, nausea, diarrhea or constipation).  Thiamine is the B vitamin that runs out first because it can only be stored for two weeks.  We need more thiamine when we're sick or under emotional stress.  Gastric Beriberi is under recognised by doctors.  An Erythrocyte Transketolace Activity test is more accurate than a blood test for thiamine deficiency, but the best way to see if you're low in thiamine is to take it and look for health improvement.  Don't take Thiamine Mononitrate because the body can't utilize it well.  Try Benfotiamine.  Thiamine is water soluble, nontoxic and safe even at high doses.  I thought it was crazy, too, but simple vitamins and minerals are important.  The eight B vitamins work together, so a B Complex, Benfotiamine,  magnesium and Vitamin D really helped get my body to start healing, along with the AIP diet.  Once you heal, you add foods back in, so the AIP diet is worth doing for a few months. I do hope you'll consider the AIP diet and Benfotiamine.
    • captaincrab55
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    • rei.b
      High DGP-A with normal IGA

      By rei.b · Posted

      Okay well the info about TTG-A actually makes a lot of sense and I wish the PA had explained that to me. But yes, I would assume I would have intestinal damage from eating a lot of gluten for 32 years while having all these symptoms. As far as avoiding gluten foods - I was definitely not doing that. Bread, pasta, quesadillas (with flour tortillas) and crackers are my 4 favorite foods and I ate at least one of those things multiple times a day e.g. breakfast with eggs and toast, a cheese quesadilla for lunch, and pasta for dinner, and crackers and cheese as a before bed snack. I'm not even kidding.  I'm not really big on sugar, so I don't really do sweets. I don't have any of those conditions.  I am not sure if I have the genes or not. When the geneticist did my genetic testing for EDS this year, I didn't think to ask for him to request the celiac genes so they didn't test for them, unfortunately.  I guess another expectation I had is  that if gluten was the issue, the gluten-free diet would make me feel better, and I'm 3 months in and that hasn't been the case. I am being very careful and reading every label because I didn't want to screw this up and have to do gluten-free for longer than necessary if I end up not having celiac. I'm literally checking everything, even tea and anything else prepacked like caramel dip. Honestly its making me anxious 😅
    • knitty kitty
      High DGP-A with normal IGA

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      So you're saying that you think you should have severe intestinal damage since you've had the symptoms so long?   DGP IgG antibodies are produced in response to a partial gluten molecule.  This is different than what tissue transglutaminase antibodies are  produced in response to.   TTg IgA antibodies are produced in the intestines in response to gluten.  The tTg IgA antibodies attack our own cells because a structural component in our cell membranes resembles a part of gluten.  There's a correlation between the level of intestinal damage with the level of tTg antibodies produced.  You are not producing a high number of tTg IgA antibodies, so your level of tissue damage in your intestines is not very bad.  Be thankful.   There may be reasons why you are not producing a high quantity of tTg IgA antibodies.  Consuming ten grams or more of gluten a day for two weeks to two months before blood tests are done is required to get sufficient antibody production and damage to the intestines.  Some undiagnosed people tend to subconsciously avoid lots of gluten.  Cookies and cakes do not contain as much gluten as artisan breads and thick chewy pizza crust.  Anemia, diabetes and thiamine deficiency can affect IgA antibody production as well.   Do you carry genes for Celiac?  They frequently go along with EDS.
    • rei.b
      High DGP-A with normal IGA

      By rei.b · Posted

      I was tested for celiac at the same time, so I wasn't taking naltrexone yet. I say that, because I don't. The endoscopy showed some mild inflammation but was inconclusive as to celiac disease. They took several biopsies and that's all that was shown. I was not given a Marsh score.
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