Immunological scarring from celiac disease

[cyclinglady]

Anyone see this article?  Could explain lingering problems for celiacs.  

https://www.sciencedaily.com/releases/2019/02/190214100033.htm

“Our new study suggests that even though short-term symptoms, such as diarrhea and abdominal pain, can be alleviated by removing gluten from the diet, long-term implications may remain, because 'tissue-healing' T cells in the bowel are permanently replaced by 'pro-inflammatory' T cells."

[squirmingitch]

Very, very interesting. Thanks for posting that cyclinglady. I wish it went into more detail. Did this involve study subjects? How many? How long were they followed? Details, details.

[Posterboy]

cyclinglady,

I think I did see that research...I can't remember if the original research said when this scarring took place....if I remember correctly it was at one year ...which I don't consider permanent.

Most refractory celiac disease is not considered permentantly scarred till the 2nd year or more.

that reminds me of...new research recently discovered...we might want to start a separate thread about it ...if this topic get's popular a "mini" 3d model of the gut that can model this hypothesis.

https://www.eurekalert.org/pub_releases/2019-05/mgh-3m050719.php

I think the research you posted was published before this research on how baking soda can silence the auto-immune reaction....really the spleen ...but microvilli can be told by the spleen to activate the immune system.

https://www.sciencedaily.com/releases/2018/04/180425093745.htm

and anything that can be activated can be deactivated... once we understand it. . and why the new findings on the 3D Mini Model of the Gut for Celiac disease is so critical...they now have a working model of how this works ....in a few years (10+years more realistically) they can develop a drug that will help celiac's. ...but the model has/had to come first.

I hope this is helpful but it is not medical advise.

Posterboy,

[ch88]

I wonder if the study were able to confirm if all of the subjects were completely gluten free.  I could see how slight or occasional cross contamination could interfere with the results. Also if they had another auto immune disorder that might cause more inflammation.