Worth Testing?

[LAR614]

If 23andme tested negative for the 2 genes they look for to determine celiac, is it worth testing any further or is that it? 

Edited October 3, 2019 by LAR614
shorter, more relevant question.

[cyclinglady]

On 10/1/2019 at 11:34 AM, LAR614 said:

If 23andme tested negative for the 2 genes they look for to determine celiac, is it worth testing any further or is that it? 

It is worth testing, if you are having issues that you think might be due to celiac disease.  That is because not all celiac genes have been identified.  We have members who have biopsied-confirmed with blood tests and have celiac diseas, yet they have different genes.  

You should not rely on a 23 and Me Test for a health diagnosis, but you probably already know that.  The  Canadian Broadcast Center did a identical twin test using 23 and Me and got different results (one twin was a journalist).  Check it out on You Tube.  

The good news if life insurance companies ever get your data, you might not be denied insurance at least for celiac disease.  How secure is that data?  

[Betsy Bee]

Better to have an M.D. do a genetics test because 23 and Me only shows the most common combo of 2 genes and might miss it. My gastro tested for HLA DQ 2.5, 2.2 and 8. If you have a rare combo of genes 23 and Me won't show it. Also your insurance should cover it if you go through your doctor and you can get a better chance of a proper diagnosis.

[Golden]

I don’t know the reliability of testing through 23 and me but my Dr. will only order the Celiac Genetic test year through Prometheus Lab. https://www.prometheuslabs.com/Products/Default.aspx?section=GIDiagnostics  I was positive for both the DQ2 and DQ8 genes. My insurance didn’t cover it, but Prometheus works with you on the cost. 

[cyclinglady]

Get the celiac disease antibodies testing.  Insurance should cover that.  About 35% of the population carries the commonly known genes that could develop into celiac disease (like 1%).  Doctors order the gene test to only exclude a celiac disease diagnosis.  It is not the first set of tests to be ordered. 

https://celiac.org/about-celiac-disease/screening-and-diagnosis/

Besides, what if your symptoms (unknown to me) are due to something like cancer or Crohn’s?