Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

2 + and 2- on blood...

Jzsnow
 Share

Recommended Posts

Jzsnow Newbie
Jzsnow
Posted

Hi y’all. My 13 year old daughter had a celiac panel a few weeks ago. Her biopsy is today. 
 

Here are the blood results:

deamidated gliadin Abs, IgA 20 (weak +)

Deamidated gliadin Abs, IgG 2 (0-19 is neg)

T-transglutaminase tTG, IgA <2 (0-3 is neg)

t-transglutaminase tTG, IgG 8 (weak + is 5-8)

So what do y’all think? Why would you have 2 positives and 2 negatives?

symptoms: always constipated, stomach pain nightly, swollen lymph nodes in her stomach, anemic for not ferritin levels but rather iron saturation, and must nap after volleyball practice, the gym, etc.

thanks!!

 

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


trents Grand Master
trents
Posted
(edited)
17 minutes ago, Jzsnow said:

Hi y’all. My 13 year old daughter had a celiac panel a few weeks ago. Her biopsy is today. 
 

Here are the blood results:

deamidated gliadin Abs, IgA 20 (weak +)

Deamidated gliadin Abs, IgG 2 (0-19 is neg)

T-transglutaminase tTG, IgA <2 (0-3 is neg)

t-transglutaminase tTG, IgG 8 (weak + is 5-8)

So what do y’all think? Why would you have 2 positives and 2 negatives?

symptoms: always constipated, stomach pain nightly, swollen lymph nodes in her stomach, anemic for not ferritin levels but rather iron saturation, and must nap after volleyball practice, the gym, etc.

thanks!!

 

Before I forget, I hope your daughter has not  been trying to eat gluten free since her blood tests were done. Doing so may have allowed healing of the small bowel villi and cloud the biopsy test results.

The centerpiece of the blood antibody labs is the tTG-IGA. It is the most specific for celiac disease and is positive. The other antibody tests are less specific for celiac disease and if they are positive it can point to other inflammatory diseases of the gut. Therefore, it is quite common for some of the antibody tests to be negative and some positive when someone has celiac disease. Do you have the result for total IGA count? If total IGA is low it depresses the individual IGA tests. Kudos to your doctor for running the full celiac antibody panel instead of just the tTG-IGA.

Keep us posted. Her symptoms scream of either celiac disease or non celiac gluten sensitivity and the blood work points to celiac disease. 

Edited by trents
Jzsnow Newbie
Jzsnow
Posted
  • Author

Oh no, we absolutely gluttoned her up prior to today. We basically had to force her to eat last night. Her stomach was hurting and she just didn’t want food anymore.

It’s is just confusing when there are 2 tTG and 2 deamidated yet she’s 1:1 for each. Makes almost zero sense to me.

8 minutes ago, trents said:

Before I forget, I hope your daughter has not  been trying to eat gluten free since her blood tests were done. Doing so may have allowed healing of the small bowel villi and cloud the biopsy test results.

The centerpiece of the blood antibody labs is the tTG-IGA. It is the most specific for celiac disease and is positive. It is quite common for some of the antibody tests to be negative and some positive when someone has celiac disease. Do you have the result for total IGA count? If total IGA is low it depresses the individual IGA tests. Kudos to your doctor for running the full celiac antibody panel instead of just the tTG-IGA.

Keep us posted. Her symptoms scream of either celiac disease or non celiac gluten sensitivity and the blood work points to celiac disease. 

You said the TTG-IGA is the most specific, but that was negative...it was <2.

trents Grand Master
trents
Posted

The biopsy is the gold standard of celiac disease diagnosis. Especially when the blood work is inconclusive. Yes, you are correct about my mistake with the TTG-IGA. My bad. I didn't look closely enough. It is also possible your daughter has non celiac gluten sensitivity which has most of the same symptoms as celiac disease but does not damage the small bowel villi.

If she has been off of gluten several weeks before the biopsy, one day of gluten cramming immediately before the biopsy will not do it. The guidelines are consumption of two slices of wheat bread daily (or the equivalent) for at least two weeks before the biopsy. Unfortunately, many docs fail to inform their patients about the need to be eating gluten regularly before testing.

Scott Adams Grand Master
Scott Adams
Posted

From the symptoms you describe and her two positive results, it does look like she may have celiac disease or non-celiac gluten sensitivity, and the treatment for either is the same, a gluten-free diet. The final confirmation would be the biopsy results, but even if that comes back negative, the true test would be if her symptoms go away on a gluten-free diet, and come back once gluten is added back.

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
 Share
Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      131,175
    • Most Online (within 30 mins)
      7,748
    Chels22
    Newest Member
    Chels22
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • Heatherisle
      Blood results

      By Heatherisle · Posted

      Daughter has started gluten free diet this week as per gastroenterologists suggestion. However says she feels more tired and like she’s been hit by a train. I suggested it could be the change to gluten free or just stress from the endoscopy last week catching up with her. Just wondering if feeling more tired is a normal reaction at this stage. I suppose it’s possible some gluten might have been present without realising. Have tried to reassure her it’s not going to resolve symptoms overnight
    • DAR girl
      Celiac and allergic to common subs and adds in prepared foods

      By DAR girl · Posted

      Looking for help sourcing gluten-free products that do not contain potato or corn derived ingredients. I have other autoimmune conditions (Psoriatic Arthritis and Sjogrens) so I’m looking for prepared foods as I have fatigue and cannot devote a lot of time to baking my own treats. 
    • Scott Adams
      Disregarded

      By Scott Adams · Posted

      I am so sorry you're going through this. It's completely understandable to feel frustrated, stressed, and disregarded after such a long and difficult health journey. It's exhausting to constantly advocate for yourself, especially when you're dealing with so many symptoms and positive diagnoses like SIBO, while still feeling unwell. The fact that you have been diligently following the diet without relief is a clear sign that something else is going on, and your doctors should be investigating other causes or complications, not dismissing your very real suffering. 
    • Oldturdle
      Paying for my own Celiac screening at WalkInLab so a positive result doesn’t become part of my medical history

      By Oldturdle · Posted

      It is just so sad that health care in the United States has come to this.  Health insurance should be available to everyone, not just the healthy or the rich.  My heart goes out to you.  I would not hesitate to have the test and pay for it myself.  My big concern would be how you could keep the results truly private.  I am sure that ultimately, you could not.  A.I. is getting more and more pervasive, and all data is available somewhere.  I don't know if you could give a fake name, or pay for your test with cash.  I certainly would not disclose any positive results on a private insurance application.  As I understand it, for an official diagnosis, an MD needs to review your labs and make the call.  If you end up in the ER, or some other situation, just request a gluten free diet, and say it is because you feel better when you don't eat gluten.      Hang in there, though.  Medicare is not that far away for you, and it will remove a lot of stress from your health care concerns.  You will even be able to "come out of the closet" about being Celiac!
    • plumbago
      Paying for my own Celiac screening at WalkInLab so a positive result doesn’t become part of my medical history

      By plumbago · Posted

      Yes, I've posted a few times about two companies: Request a Test and Ulta Labs. Also, pretty much we can all request any test we want (with the possible exception of the N protein Covid test and I'm sure a couple of others) with Lab Corp (or Pixel by Lab Corp) and Quest. I much prefer Lab Corp for their professionalism, ease of service and having it together administratively, at least in DC. And just so you know, Request a Test uses Lab Corp and Quest anyway, while Ulta Labs uses only Quest. Ulta Labs is cheaper than Request a Test, but I am tired of dealing with Quest, so I don't use them so much.
×
×
  • Create New...