Questions about results of endoscopy

[Macala]

I have my results but I need help to understand them. 

Final Diagnosis:
Duodenum, biopsy:
Normal duodenal mucosa.
No evidence of celiac sprue, Giardia, cryptosporidia or microsporidia.

Gross Description:
Received in formalin and identified as "duodenal biopsy R/O Celiac"
are multiple fragments of tan tissue which collectively measure 1.1 x
0.2 x 0.2 cm.  The specimen is entirely submitted in one cassette.

Microscopic Description:
Slide(s) Examined: 1 H\T\E.

[trents]

13 minutes ago, Macala said:

I have my results but I need help to understand them. 

Final Diagnosis:
Duodenum, biopsy:
Normal duodenal mucosa.
No evidence of celiac sprue, Giardia, cryptosporidia or microsporidia.

Gross Description:
Received in formalin and identified as "duodenal biopsy R/O Celiac"
are multiple fragments of tan tissue which collectively measure 1.1 x
0.2 x 0.2 cm.  The specimen is entirely submitted in one cassette.

Microscopic Description:
Slide(s) Examined: 1 H\T\E.

If you were being biopsied for suspicion of celiac disease,  I have highlighted in red the relevant results. If you have symptoms that led you to suspect celiac disease then you may have NCGS (Non Celiac Gluten Sensitivity). The two conditions share many of the same symptoms but with NCGS there is no damage of the villi ("mucosa") that line the small bowel (aka, the "duodenum") so that is why your biopsy is negative.  There is no test for NCGS. Celiac disease must first be ruled out. The antidote is the same for both conditions, namely, total avoidance of gluten for life. Hope this helps.

Edited May 1, 2022 by trents

[RMJ]

“Duodenal biopsy R/O Celiac” means Duodenal biopsy to rule out celiac. This information helps the pathologist know that he was to look for celiac damage. Since he mentioned Giardia and other microorganisms it means that he also looked for things besides celiac disease.

[Wheatwacked]

That Celiac Disease has been ruled out by biopsy does not mean your symptoms are psychosomatic. As @trents said it is simply the first step in diagnosing Non-Celiac Gluten Sensitivity. The next step a wise doctor would take is a trial Gluten Free Diet to see if your symptoms improve and then a Gluten Challenge trial to see if they return.  He could run a blood panel for Celiac, but since the biopsy is necessary in the US for diagnosis, it makes more sense to me, not a doctor, to do the GFD, then the Gluten Challange at the end of which run the blood panel. It would also be good to know your blood plasma vitamin D level and look for any vitamin deficiencies. In Americans choline and potassium intake less than the Adequate Intake (AI) is common.  Low Vitamin D is a common finding in many autoimmune diseases. You may have caught it early enough to not have caused visible damage yet.

Vitamin D and the Immune System] Vitamin D Is Not as Toxic as Was Once Thought; Could we be overlooking a potential choline crisis in the United Kingdom?; 

Note in the sample label that 510 mg of potassium is 10% DV. Calculated out  the Daily Values (DV) fo potassium is 5100 mg. https://www.fda.gov/food/food-labeling-nutrition/changes-nutrition-facts-label.

Quote

The DV for potassium is 4,700 mg for adults and children age 4 years and older [17]. FDA requires the new food labels to list potassium content. Foods providing 20% or more of the DV are considered to be high sources of a nutrient, but foods providing lower percentages of the DV also contribute to a healthful diet.   https://ods.od.nih.gov/factsheets/Potassium-HealthProfessional/#:~:text=The DV for potassium is,contribute to a healthful diet. 

Edited May 1, 2022 by Wheatwacked