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What do these labs mean?

Woman1978
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Woman1978 Newbie
Woman1978
Posted

Hi Everyone, 

I recently had a celiac disease panel. Here are the results:

Celiac Disease Complete Panel:

Immunoglobulin A, Qn, Serum 197 mg/dL reference interval 87-352

Deamidated Gliadin Abs, IgA 3 units (reference interval 0-19)

Deamidated Gliadin Abs, IgG 29 units 0-19 reference interval (this one is high)

t-Transglutaminase (tTG) IgA <2 U/mL 0-3 reference interval

 

I'd love your feedback.

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trents Grand Master
trents
Posted

Welcome to the forum, Woman1978.

The short answer is, it means you could or probably have celiac disease.

The tTG-IGA is the most commonly ordered lab to detect celiac disease. It combines good specificity with good sensitivity. But for whatever reason, some people's immune system reacts atypically so as to not trigger a positive for this one.

The Deamidated Gliadin Abs, IgG is an alternate test for celiac disease.

Were you eating regular amounts of gluten right up to the time of the blood draw? Sometimes people make the mistake of begging the gluten free diet before all testing is complete. This can cause false negatives.

What symptoms do you have?

Woman1978 Newbie
Woman1978
Posted
  • Author
  On 5/28/2022 at 1:30 AM, trents said:

Welcome to the forum, Woman1978.

The short answer is, it means you could or probably have celiac disease.

The tTG-IGA is the most commonly ordered lab to detect celiac disease. It combines good specificity with good sensitivity. But for whatever reason, some people's immune system reacts atypically so as to not trigger a positive for this one.

The Deamidated Gliadin Abs, IgG is an alternate test for celiac disease.

Were you eating regular amounts of gluten right up to the time of the blood draw? Sometimes people make the mistake of begging the gluten free diet before all testing is complete. This can cause false negatives.

What symptoms do you have?

Expand Quote  

Thank you for your response. Yes, I was eating gluten. Symptoms include joint pain, bloating, belching, flatulence, lactose intolerance and bouts of constipation.

trents Grand Master
trents
Posted

Your next diagnostic step would seem to be an endoscopy with biopsy.

Woman1978 Newbie
Woman1978
Posted
  • Author
  On 5/28/2022 at 2:35 AM, trents said:

Your next diagnostic step would seem to be an endoscopy with biopsy.

Expand Quote  

That's what I thought! Thank you!

 

trents Grand Master
trents
Posted
  On 5/28/2022 at 2:38 AM, Woman1978 said:

That's what I thought! Thank you!

 

Expand Quote  

Don't quit eating gluten if you are planning on an endoscopy/biopsy. 2 slices of wheat bread daily or the equivalent.

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